2-(2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)acetamide
• 英文别名: 2-(2-amino-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-yl)acetamide
• 化学式: C₈H₁₂N₄OS
• 分子量: 212.275
• InChiKey: MWQKGEMNKITLRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-碘乙酰胺 、 4,5,6,7-四氢噻唑[5,4-C]吡啶-2-胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 以54%的产率得到2-(2-amino-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)acetamide
  参考文献：
  名称：

  [EN] PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS
  [FR] ANALOGUES DE PURINE ET DE 3-DÉAZAPURINE EN TANT QU'INHIBITEURS DE LA CHOLINE KINASE

  摘要：

  本发明提供了替代嘌呤和3-去氨基嘌呤类似物，可以调节胆碱激酶（ChoK）的活性。因此，本发明的化合物在治疗由改变的胆碱代谢引起的疾病方面是有用的，如癌症、细胞增殖紊乱、不同起源的传染病、免疫相关疾病和神经退行性疾病。本发明还提供了制备这些化合物的方法、包含这些化合物的药物组合物、以及利用包含这些化合物的药物组合物治疗疾病的方法。

  公开号：

  WO2018019681A1

文献信息

• Purine and 3-deazapurine analogues as choline kinase inhibitors
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US10683292B2

  公开（公告）日：2020-06-16

  There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

  本发明提供了可调节胆碱激酶（ChoK）活性的取代嘌呤和 3-去氮嘌呤类似物。因此，本发明的化合物可用于治疗由胆碱代谢改变引起的疾病，如癌症、细胞增殖性疾病、不同来源的传染性疾病、免疫相关疾病和神经退行性疾病。本发明还提供了制备这些化合物的方法、包含这些化合物的药物组合物，以及利用包含这些化合物的药物组合物治疗疾病的方法。
• PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US20190225615A1

  公开（公告）日：2019-07-25

  There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
• [EN] PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS<br/>[FR] ANALOGUES DE PURINE ET DE 3-DÉAZAPURINE EN TANT QU'INHIBITEURS DE LA CHOLINE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2018019681A1

  公开（公告）日：2018-02-01

  There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

  本发明提供了替代嘌呤和3-去氨基嘌呤类似物，可以调节胆碱激酶（ChoK）的活性。因此，本发明的化合物在治疗由改变的胆碱代谢引起的疾病方面是有用的，如癌症、细胞增殖紊乱、不同起源的传染病、免疫相关疾病和神经退行性疾病。本发明还提供了制备这些化合物的方法、包含这些化合物的药物组合物、以及利用包含这些化合物的药物组合物治疗疾病的方法。