PDC-glutaminate ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: PDC-glutaminate ester
• 英文别名: [2-[(2S)-2,5-diamino-5-oxopentanoyl]oxy-3-pentadecylphenyl] (2S)-2,5-diamino-5-oxopentanoate
• 化学式: C₃₁H₅₂N₄O₆
• 分子量: 576.777
• InChiKey: CSUMINPASUSRDC-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  41
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  191
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Boc-beta-丙氨酸 、 PDC-glutaminate ester 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Compositions for prevention/prophylactic treatment of poison ivy dermatitis

  摘要：

  本发明在一个或多个实施例中，包括3-正十五烷基儿茶酚（毒葛树脂酸饱和同系物）和/或3-正十七烷基儿茶酚（毒橡树脂酸饱和同系物）的水溶性衍生物，作为用于预防和/或预防性治疗由毒葛和毒橡引起的接触性皮炎的组合物。本发明还涉及制备这种化合物的方法。公开的化合物对于使主体对漆树科和银杏科植物中含有的过敏原耐受和脱敏是有效的，包括通式（I）的水溶性树脂酸饱和同系物，通过给予含有至少一种水溶性树脂酸饱和酯化合物的组合物来使哺乳动物，包括人类，对漆树科和银杏科植物中含有的过敏原耐受和脱敏。

  公开号：

  US09408822B2

文献信息

• [EN] COMPOSITIONS FOR PREVENTION/PROPHYLACTIC TREATMENT OF POISON IVY DERMATITIS<br/>[FR] COMPOSITIONS POUR LA PRÉVENTION/LE TRAITEMENT PROPHYLACTIQUE DE LA DERMATITE PROVOQUÉE PAR LE SUMAC VÉNÉNEUX
  申请人：THE UNIV OF MISSISSIPPI

  公开号：WO2016160090A1

  公开（公告）日：2016-10-06

  The present invention, in one or more embodiments, comprises derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3 -n-heptadecyl catechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising urushiol esters of general formula (IA) [Formula should be entered here] tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a formulation containing at least one urushiol ester compound.

  本发明在一个或多个实施例中，包括3-正十五烷基儿茶酚（毒葛酚醛酸酯饱和同分异构体）和/或3-正十七烷基儿茶酚（毒橡胶酚醛酸酯饱和同分异构体）的衍生物，作为预防和/或预防性治疗由毒葛和毒橡胶引起的接触性皮炎的组合物。本发明还涉及制备这种化合物的过程。本发明揭示了能够对抗漆树科和银杏科植物中含有的过敏原，包括通式（IA）[应在此处输入公式]的漆醇酯化合物，能够对哺乳动物，包括人类，进行耐受和脱敏，达到的方法是给予含有至少一种漆醇酯化合物的配方。
• COMPOSITIONS FOR PREVENTION/PROPHYLACTIC TREATMENT OF POISON IVY DERMATITIS
  申请人：Elsohly Mahmoud A.

  公开号：US20110086900A1

  公开（公告）日：2011-04-14

  The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.
• US8486998B2
  申请人：——

  公开号：US8486998B2

  公开（公告）日：2013-07-16
• US9029417B2
  申请人：——

  公开号：US9029417B2

  公开（公告）日：2015-05-12
• [EN] COMPOSITIONS FOR PREVENTION/PROPHYLACTIC TREATMENT OF POISON IVY DERMATITIS<br/>[FR] COMPOSITIONS POUR PRÉVENTION/TRAITEMENT PROPHYLACTIQUE DE DERMITE DUE AU SUMAC VÉNÉNEUX
  申请人：UNIV MISSISSIPPI

  公开号：WO2009146131A2

  公开（公告）日：2009-12-03

  The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.