2-(hydroxy-nitroso-amino)-butyric acid | 727644-71-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(hydroxy-nitroso-amino)-butyric acid
• 英文别名: α-(Nitrosohydroxylamino)-propan-α-carbonsaeure；α-Isonitramino-buttersaeure；α-(Nitrosohydroxylamino)-buttersaeure；2-(Hydroxy-nitroso-amino)-buttersaeure；2-(Nitrosohydroxylamino)-butansaeure-(1)；2-[hydroxy(nitroso)amino]butanoic acid
• CAS: 727644-71-5
• 化学式: C₄H₈N₂O₄
• mdl: MFCD19229453
• 分子量: 148.119
• InChiKey: ZTYNTXRLGSOMGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.38
• 重原子数：
  10.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  90.2
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(hydroxy-nitroso-amino)-butyric acid 在 sodium amalgam 作用下， 生成 2-hydrazinobutyric acid
  参考文献：
  名称：

  Gender difference in the mean age at the induction of hemodialysis in patients with autosomal dominant polycystic kidney disease

  摘要：

  Male patients with autosomal dominant polycystic kidney disease (ADPKD) begin hemodialysis earlier than female patients, The rate of progression of many other renal diseases is also faster in men than women. In this study, gender difference in ADPKD was compared with that in other diseases, such as chronic glomerulonephritis, diabetic nephropathy, and nephrosclerosis, using the data obtained from an annual statistical survey of the Japanese Society for Dialysis Therapy, The male-female ratio in ADPKD (n = 8,176) was 1.17:1 and closer to 1.0:1 than the other diseases. Men with ADPKD started hemodialysis therapy 1.3 years earlier than women (male age, 55.9 +/- 12.4 years versus female age, 57.2 +/- 11.5 years), and the age difference was less than that in other diseases. These results suggest that the prognosis in women with ADPKD is relatively worse than that in men with ADPKD or that women are not well protected against the progression of this disease compared with other renal diseases. In conclusion, men with ADPKD are introduced to hemodialysis therapy earlier than women; however, the age difference was small compared with other common renal diseases. (C) 2000 by the National Kidney Foundation, Inc.

  DOI：

  10.1016/s0272-6386(00)70042-4
• 作为产物：
  描述：

  2-乙基乙酰乙酸乙酯 在 乙醇 、 potassium ethoxide 、 氧化亚氮 作用下， 生成 2-(hydroxy-nitroso-amino)-butyric acid
  参考文献：
  名称：

  Traube,W., Chemische Berichte, 1895, vol. 28, p. 1793

  摘要：

  DOI：

文献信息

• Gender difference in the mean age at the induction of hemodialysis in patients with autosomal dominant polycystic kidney disease
  作者：Isao Ishikawa、Kenji Maeda、Shigeru Nakai、Yoshindo Kawaguchi

  DOI：10.1016/s0272-6386(00)70042-4

  日期：2000.6

  Male patients with autosomal dominant polycystic kidney disease (ADPKD) begin hemodialysis earlier than female patients, The rate of progression of many other renal diseases is also faster in men than women. In this study, gender difference in ADPKD was compared with that in other diseases, such as chronic glomerulonephritis, diabetic nephropathy, and nephrosclerosis, using the data obtained from an annual statistical survey of the Japanese Society for Dialysis Therapy, The male-female ratio in ADPKD (n = 8,176) was 1.17:1 and closer to 1.0:1 than the other diseases. Men with ADPKD started hemodialysis therapy 1.3 years earlier than women (male age, 55.9 +/- 12.4 years versus female age, 57.2 +/- 11.5 years), and the age difference was less than that in other diseases. These results suggest that the prognosis in women with ADPKD is relatively worse than that in men with ADPKD or that women are not well protected against the progression of this disease compared with other renal diseases. In conclusion, men with ADPKD are introduced to hemodialysis therapy earlier than women; however, the age difference was small compared with other common renal diseases. (C) 2000 by the National Kidney Foundation, Inc.
• Traube,W., Chemische Berichte, 1895, vol. 28, p. 1793
  作者：Traube,W.

  DOI：——

  日期：——