7-aminoheptanamide | 98433-13-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-aminoheptanamide
• CAS: 98433-13-7
• 化学式: C₇H₁₆N₂O
• 分子量: 144.217
• InChiKey: INHIGTCHLZOFDP-UHFFFAOYSA-N

物化性质

• 沸点：
  320.3±25.0 °C(Predicted)
• 密度：
  0.970±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-aminoheptanamide 在 硫酸 作用下， 以 四氢呋喃 为溶剂， 反应 78.0h， 生成 ω- bis(benzyloxycarbonyl)guanidino-α-(methoxymethyl ester)
  参考文献：
  名称：

  Total synthesis of (.+-.)-15-deoxyspergualin

  摘要：

  DOI：

  10.1021/jo00385a010
• 作为产物：
  描述：

  6-cyanohexanamide 在 1,4-二氧六环 、 氨 、 镍 作用下， 80.0 ℃ 、9.81 MPa 条件下， 生成 7-aminoheptanamide
  参考文献：
  名称：

  Berther, Chemische Berichte, 1959, vol. 92, p. 2616,2619

  摘要：

  DOI：

文献信息

• [EN] A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS<br/>[FR] NOUVELLE CLASSE D'AGONISTES DU RÉCEPTEUR MU-OPIOÏDE
  申请人：UNIV COLUMBIA

  公开号：WO2015138791A1

  公开（公告）日：2015-09-17

  The present invention provides a compound having the structure (I) or a pharmaceutically acceptable salt or ester thereof.

  本发明提供了一种具有结构（I）的化合物或其药用可接受的盐或酯。
• [EN] MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR<br/>[FR] AGONISTES DE RÉCEPTEURS D'OPIOÏDES ΜU ET LEURS UTILISATIONS
  申请人：KURES INC

  公开号：WO2022074587A1

  公开（公告）日：2022-04-14

  The present disclosure relates to a compound having the structure: Formula (I) or a pharmaceutically acceptable salt or ester thereof, for treating or preventing a neurological disorder, including Huntington's disease, Rett syndrome, and CDKL5 disorder.

  本公开涉及一种具有结构式：Formula(I)或其药学上可接受的盐或酯，用于治疗或预防神经系统疾病，包括亨廷顿病、雷特综合症和CDKL5症状。
• Liquophilic polyamide membrane filter media and process of preparation thereof
  申请人：PALL CORPORATION

  公开号：EP0050789A1

  公开（公告）日：1982-05-05

  A process is provided for preparing skinless liquophilic alcohol-insoluble polyamide membranes by preparing at a first temperature a solution in a polyamide solvent having a temperature coefficient of solubility within the range from about 0.01 to about 5 weight per cent per degree Centrigrade of an alcohol-insoluble polyamide resin having a ratio CH2:NHCO of methylene CH2 to amide NHCO groups within the range from about 7:1 to about 12:1; inducing nucleation of the solution by controlled addition to the solution of a nonsolvent for the polyamide resin, under controlled conditions of concentration, temperature, addition rate, and degree of agitation to obtain a visible precipitate of polyamide resin particles which may or may not thereafter partially or completely redissolve, thereby forming a casting solution; spreading the casting solution on a substrate to form a thin film thereof on the substrate; cooling the film of casting solution to a second temperature sufficiently lower than the first temperature to precipitate polyamide resin from the casting solution; contacting and diluting the film of casting solution with a nonsolvent liquid, preferably containing a substantial proportion of the solvent liquid but less than the proportion in the casting solution, to precipitate polyamide resin from the casting solution in the form of a thin skinless liquophilic membrane; and washing and drying the resulting membrane; the alcohol-insoluble polyamide membranes obtained by this process have the unusual property of being liquophilic, i.e., readily wetted by organic liquids having a surface tension below about 60 dynesicm, while being substantially not wetted by water, have absolute particle removal capabilities of the order of 0.1 to 5 11M or more, and are useful as filter media for liquid systems in which such organic liquids are the continuous phase, as well as for separating immiscible liquid mixtures containing such liquids and liquids having a higher surface tension such as water.

  本发明提供了一种用于制备无皮亲液性醇不溶性聚酰胺膜的工艺，其方法是在第一 温度下制备聚酰胺溶剂中的溶液，该溶液的溶解度温度系数在每摄氏度约 0.01至约5重量％/摄氏度的醇不溶性聚酰胺树脂的溶液，其亚甲基CH2与酰胺NHCO基团的 :NHCO比在约7:1至约12：在控制浓度、温度、添加速率和搅拌程度的条件下，向溶液中加入聚酰胺树脂的非溶剂，诱导溶液成核，以获得聚酰胺树脂颗粒的可见沉淀物，该沉淀物此后可能部分或完全再溶解，也可能不完全再溶解，从而形成浇铸溶液；将浇铸溶液涂抹在基底上，在基底上形成一层薄膜；将浇铸溶液薄膜冷却到比第一温度足够低的第二温度，以便从浇铸溶液中析出聚酰胺树脂；将浇铸溶液薄膜与一种非溶剂液体接触并稀释，该非溶剂液体最好含有相当比例的溶剂液体，但小于浇铸溶液中的比例，以便从浇铸溶液中析出聚酰胺树脂，形成一层薄的无皮嗜液膜；以及洗涤和干燥所得到的膜；通过该工艺得到的醇不溶性聚酰胺膜具有不寻常的嗜液特性，即.............e.,易被表面张力低于约 60 达因西克米的有机液体润湿，而基本上不被水润湿，具有 0.1 至 5 11M 或更高数量级的绝对颗粒去除能力，可用作以此类有机液体为连续相的液体系统的过滤介质，也可用于分离含有此类液体和具有较高表面张力的液体（如水）的不溶液体混合物。
• Methods of concentrating ligands and active membranes used therefor
  申请人：PALL CORPORATION

  公开号：EP0173500A1

  公开（公告）日：1986-03-05

  A chemically active membrane having a large surface area is provided in which a hydrophilic, microporous, skinless, polyamide membrane (12) is chemically bound to a residue of an activating agent which is capable of reacting with a biologically active material. The chemically active membrane, formed by reacting a hydrophilic, microporous, skinless, polyamide membrane (12) with an activating agent may be used to prepare a biologically active membrane (10) having a large surface area which comprises an acceptor molecule such as an monoclonal antibody, a polyclonal antibody, an antigenic substance, a glycoprotein, Protein A, a lectin, a carbohydrate, an anzyme substrate, a cofactor, an inhibitor, a hormone, an IgG class of immunoglobulin, carrier protein, a receptor, heparin, a coagulation factor, or a histone covalently bound to the hydrophilic, microporous, skinless, polyamide membrane (12) by reacting the chemically activate membrane with the acceptor molecule.

  本发明提供了一种具有大表面积的化学活性膜，其中亲水、微孔、无皮聚酰胺膜（12）与活化剂残留物化学结合，活化剂残留物能够与生物活性材料发生反应。通过亲水、微孔、无皮、聚酰胺膜（12）与活化剂反应形成的化学活性膜可用于制备具有大表面积的生物活性膜（10），该生物活性膜包含受体分子，如单克隆抗体、多克隆抗体、抗原物质、糖蛋白、蛋白质 A、凝集素、蛋白质 B、蛋白质 C、蛋白质 D 和蛋白质 E、蛋白 A、凝集素、碳水化合物、酶底物、辅助因子、抑制剂、激素、IgG 类免疫球蛋白、载体蛋白、受体、肝素、凝血因子或组蛋白，通过化学活化膜与受体分子反应，共价结合到亲水性微孔无皮聚酰胺膜（12）上。
• Filtration membranes
  申请人：PALL CORPORATION

  公开号：EP0272842A2

  公开（公告）日：1988-06-29

  A porous polymeric medium having low protein affinity is provided comprising a porous polymeric substrate and a polymer coating having a low affinity for amide group-containing materials formed in situ at the surface of the porous polymeric substrate from a polymer having a plurality of hydroxyl groups and a cross-linking agent having functional groups which react with the hydroxyl groups.

  提供了一种具有低蛋白质亲和力的多孔聚合物介质，包括多孔聚合物基底和在多孔聚合物基底表面由具有多个羟基的聚合物和具有与羟基反应的官能团的交联剂就地形成的对含酰胺基材料具有低亲和力的聚合物涂层。