2-(4-Chlorophenyl)-3-methyl-1-butanol | 65079-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Chlorophenyl)-3-methyl-1-butanol
• 英文别名: 2-(4-chlorophenyl)-3-methylbutanol；2-(4-Chlorophenyl)-3-methylbutan-1-ol
• CAS: 65079-44-9
• 化学式: C₁₁H₁₅ClO
• 分子量: 198.692
• InChiKey: MZYGDCHJNAZTMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-溴苄溴 、 2-(4-Chlorophenyl)-3-methyl-1-butanol 在 氢氧化钾 、 四丁基碘化铵 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以72%的产率得到3-Methyl-2-(p-chlorophenyl)butyl m-bromobenzyl ether
  参考文献：
  名称：

  Synthesis of ethophenprox analogs

  摘要：

  The synthesis of ethophenprox analogs was performed by condensation of alcohols with benzyl halides under conditions of the phase transfer catalysis. The ultrasonic irradiation was shown to accelerate the reaction and to increase the yield of ethers. The trends in fragmentation of new generation pyrethroids under the electron impact were established. Insecticidal activity of the compounds obtained was evaluated.

  DOI：

  10.1007/bf02757439
• 作为产物：
  描述：

  3-甲基-2-(4-氯苯基)丁酰氯 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-(4-Chlorophenyl)-3-methyl-1-butanol
  参考文献：
  名称：

  Oxidation of primary and secondary alcohols by the catalysis of palladium

  摘要：

  DOI：

  10.1021/jo00156a028

文献信息

• Benzyl ethers
  申请人：Shell Oil Company

  公开号：US04073812A1

  公开（公告）日：1978-02-14

  Pesticidal benzyl ethers of the formula: ##STR1## wherein each symbol has a meaning defined in the specification.

  公式为：##STR1## 其中每个符号的含义在说明书中定义。这是关于杀虫苯基醚的公式。
• Heterocyclic derivatives as modulators of ion channels
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2308872A1

  公开（公告）日：2011-04-13

  The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及可用作离子通道抑制剂的杂环衍生物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
• N‐Directed defluorinative <i>γ</i>‐C(sp³)−H allylation of sulfamate esters for synthesis of <i>gem</i>‐difluoroalkenes via photoredox catalysis
  作者：Jia‐Wen Yang、Meng Li、Guang‐Qiang Tan、Feng Liu、Hai‐Tao Qin

  DOI：10.1002/ejoc.202400011

  日期：——

  A photocatalytic site-selective functionalization of sulfamate esters derivatives was described. This transformation was achieved through amidyl radical directed 1,6-hydrogen atom transfer and intermolecular radical addition, providing a simple and practical approach for the synthesis of gem-difluoroalkene-containing sulfamate esters. Besides, this protocol proceeds under redox-neutral conditions.

  描述了氨基磺酸酯衍生物的光催化位点选择性官能化。该转化是通过酰胺基引导的1,6-氢原子转移和分子间自由基加成实现的，为含偕二氟烯烃的氨基磺酸酯的合成提供了一种简单实用的方法。此外，该协议在氧化还原中性条件下进行。
• <i>γ</i>-Alkylation of Alcohols Enabled by Visible-Light Induced 1,6-Hydrogen Atom Transfer
  作者：Wei Shu、Hui Zhang、Yan Huang

  DOI：10.1021/acs.orglett.9b02255

  日期：2019.8.2

  Site-selective remote alkylation of alcohol is attractive but challenging in organic synthesis. Herein, we report a novel visible-light mediated gamma-alkylation of alcohol derivatives via the formation of C-sp3-C-sp3 bond through C-sp3-H bond functionalization under mild conditions. The use of sulfamate esters enables the directed, otherwise rare 1,6-HAT to generate gamma-selective C-centered radical, which is complementary to delta-selective 1,5-HAT of alcohols. This redox-neutral protocol provides a general and operationally simple method to access gamma-alkylated alcohols.
• Galin, F. Z.; Rakhimov, R. G.; Tolstikov, G. A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 1.2, p. 170
  作者：Galin, F. Z.、Rakhimov, R. G.、Tolstikov, G. A.

  DOI：——

  日期：——