(3-benzyloxy-1,1-dimethylpropoxy)methoxydiphenylsilane | 485325-14-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-benzyloxy-1,1-dimethylpropoxy)methoxydiphenylsilane
• CAS: 485325-14-2
• 化学式: C₂₅H₃₀O₃Si
• 分子量: 406.597
• InChiKey: BBCUJAJGWBNJAN-UHFFFAOYSA-N

物化性质

• 沸点：
  474.4±37.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.29
• 重原子数：
  29.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (3-benzyloxy-1,1-dimethylpropoxy)methoxydiphenylsilane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 二苯基二氟硅烷
  参考文献：
  名称：

  Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry

  摘要：

  Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1 degrees, 2 degrees, 3 degrees alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2006.10.052
• 作为产物：
  描述：

  异戊二醇 在 4-二甲氨基吡啶 、 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成 (3-benzyloxy-1,1-dimethylpropoxy)methoxydiphenylsilane
  参考文献：
  名称：

  Novel silyl linkers for solid-phase synthesis

  摘要：

  The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of V alcohols, 2degrees alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3degrees alcohols to the solid-phase. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01213-3