[2-(chloromethyl)phenyl]phenylmethanone | 20878-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(chloromethyl)phenyl]phenylmethanone
• 英文别名: chloromethylbenzophenone；2-Chlormethyl-benzophenon；(2-(Chloromethyl)phenyl)(phenyl)methanone；[2-(chloromethyl)phenyl]-phenylmethanone
• CAS: 20878-43-7
• 化学式: C₁₄H₁₁ClO
• 分子量: 230.694
• InChiKey: ZSOXNXDUYPYGJO-UHFFFAOYSA-N

物化性质

• 沸点：
  392.5±25.0 °C(Predicted)
• 密度：
  1.181±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [2-(chloromethyl)phenyl]phenylmethanone 在 sodium hydrosulfide hydrate 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 3.25h， 以45%的产率得到1-phenylbenzo[c]thiophene
  参考文献：
  名称：

  2-(氯甲基)苯基锂与芳香醛反应高效合成1-芳基苯并[c]噻吩

  摘要：

  A simple and efficient sequence for the preparation of 1-arylbenzo[c]thiophenes has been developed. Thus, 2-(chloromethyl)-phenyllithiums, generated by treating 2-(chloromethyl)phenyl bromides with butyllithium, are allowed to react with aromatic aldehydes to afford the corresponding diarylmethanol derivatives. These alcohols are oxidized with pyridinium chlorochromate (PCC) to give aryl[(2-chloromethyl)phenyl]-methanones, of which treatment with sodium hydrogensulfide gives 1-aryl-1,3dihydrobenzo[c]thiophen-1-ols. Dehydration of these crude alcohols to the desired products can be accomplished by the treatment with a catalytic amount of p-toluenesulfonic acid.

  DOI：

  10.3987/com-17-13767
• 作为产物：
  描述：

  2-甲基二苯甲酮 在 氯 作用下， 生成 [2-(chloromethyl)phenyl]phenylmethanone
  参考文献：
  名称：

  �ber die Einwirkung von Ammoniak auf arylsubstituierte Indone in Abwesenheit von Metallsalzen

  摘要：

  DOI：

  10.1007/bf00904335

文献信息

• Process for the production of living radical polymers and polymers
  申请人：Yamago Shigeru

  公开号：US20060135711A1

  公开（公告）日：2006-06-22

  A process for producing a living radical polymer characterized in that a vinyl monomer is polymerized with use of an organotellurium compound represented by the formula (1) and an azo type polymerization initiator, and the living radical polymer obtainable by the process wherein R 1 is C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 2 and R 3 are each a hydrogen atom or C 1 -C 8 alkyl, and R 4 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, oxycarbonyl or cyano.

  使用由公式（1）表示的有机碲化合物和偶氮类聚合引发剂聚合乙烯单体的生活自由基聚合物的生产方法，其中所述生活自由基聚合物可通过该方法获得 其中R1为C1-C8烷基，芳基，取代芳基或芳香杂环基，R2和R3分别为氢原子或C1-C8烷基，R4为芳基，取代芳基，芳香杂环基，酰基，氧羰基或氰基。
• 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES
  申请人：FETTER Jozsef

  公开号：US20120252784A1

  公开（公告）日：2012-10-04

  Novel 2,3,4-benzothiadiazepines-2,2-dioxides and processes for the preparation thereof are disclosed. The compounds influence the central nervous system and may be used to treat or prevent Alzheimer's disease, Parkinson's disease or Huntington's disease, senile dementia not of the Alzheimer's type, vascular dementia, post-stroke dementia, Korsakoff's syndrome, Down's syndrome, schizophrenia, panic disorder, post-traumatic stress disorder, anxiety or depression.

  揭示了新型2,3,4-苯并噻二唑二氧化物及其制备方法。这些化合物影响中枢神经系统，可用于治疗或预防阿尔茨海默病、帕金森病或亨廷顿病、老年性非阿尔茨海默型痴呆、血管性痴呆、中风后痴呆、科萨科夫综合征、唐氏综合征、精神分裂症、恐慌症、创伤后应激障碍、焦虑或抑郁症。
• Organic tellurium compound, process for producing the same, living radical polymerization initiator, process for producing polymer with the same, and polymer
  申请人：Yamago Shigeru

  公开号：US20050245714A1

  公开（公告）日：2005-11-03

  An organotellurium compound of the formula (1) is useful as a living radical polymerization initiator and makes possible precision control of molecular weights and molecular weight distributions under mild conditions wherein R 1 is C 1 -C 8 alkyl, R 2 and R 3 are each a hydrogen atom or C 1 -C 8 alkyl, and R 4 is aryl, substituted aryl, aromatic heterocyclic group, hydroxycarbonyl or cyano.

  化学式为（1）的有机碲化合物可用作活性自由基聚合引发剂，能够在温和条件下实现分子量和分子量分布的精确控制。其中，R1为C1-C8烷基，R2和R3分别为氢原子或C1-C8烷基，R4为芳基，取代芳基，芳香族杂环基，羟基羰基或氰基。
• Organic Bismuth Compound, Method for Producing Same, Living Radical Polymerization Initiator, Method for Producing Polymer Using Same, and Polymer
  申请人：Yamago Shigeru

  公开号：US20070265404A1

  公开（公告）日：2007-11-15

  An organobismuth compound represented by the formula (1) wherein R 1 and R 2 are C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 3 and R 4 are each a hydrogen atom or C 1 -C 8 alkyl, and R 5 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, amido, oxycarbonyl or cyano.

  一种有机铋化合物，其化学式为(1)，其中R1和R2为C1-C8烷基、芳基、取代芳基或芳香族杂环基，R3和R4分别为氢原子或C1-C8烷基，R5为芳基、取代芳基、芳香族杂环基、酰基、酰胺基、氧羰基或氰基。
• Organic antimony compound, process for producing the same, living radical polymerization initiator, process for producing polymer using the same, and polymer
  申请人：Yamago Shigeru

  公开号：US20090299008A1

  公开（公告）日：2009-12-03

  An organoantimony compound represented by the formula (1), processes for producing polymers with use of the compound, and polymers wherein R 1 and R 2 are C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 3 and R 4 are each a hydrogen atom or C 1 -C 8 alkyl, and R 5 is aryl, substituted aryl, an aromatic heterocyclic group, oxycarbonyl or cyano.

  一种有机锑化合物，其化学式表示为（1），使用该化合物生产聚合物的方法，以及其中R1和R2为C1-C8烷基，芳基，取代芳基或芳香族杂环基，R3和R4分别为氢原子或C1-C8烷基，R5为芳基，取代芳基，芳香族杂环基，氧羰基或氰基的聚合物。