嘧啶,2-(4-甲氧苯基)-4,6-二甲基- | 154499-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 嘧啶,2-(4-甲氧苯基)-4,6-二甲基-
• 英文名称: 4,6-bis-methyl-2-(4'-methoxyphenyl)pyrimidine
• 英文别名: 2-(4-methoxyphenyl)-4,6-dimethylpyrimidine；2-(p-methoxyphenyl)-4,6-dimethylpyrimidine；4,6-dimethyl-2-(p-anisyl)pyrimidine；2-(4-methoxy-phenyl)-4,6-dimethyl-pyrimidine；2-(4-Methoxy-phenyl)-4,6-dimethyl-pyrimidin；4,6-Dimethyl-2-(4-methoxyphenyl)pyrimidine
• CAS: 154499-87-3
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: MGFMUGAPYBKBCZ-UHFFFAOYSA-N

物化性质

• 沸点：
  264.5±32.0 °C(Predicted)
• 密度：
  1.083±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  嘧啶,2-(4-甲氧苯基)-4,6-二甲基- 在 氢溴酸 作用下， 生成 4-(4,6-dimethyl-pyrimidin-2-yl)-phenol
  参考文献：
  名称：

  Gabriel; Colman, Chemische Berichte, 1899, vol. 32, p. 1533,2930, 2934

  摘要：

  DOI：
• 作为产物：
  描述：

  4,6-二甲基-2-羟基嘧啶 在 四(三苯基膦)钯 、 正丁基锂 、 TEA 、 zinc dibromide 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 嘧啶,2-(4-甲氧苯基)-4,6-二甲基-
  参考文献：
  名称：

  Synthesis of Pyrimidinyl Triflates and Palladium-catalyzed Coupling with Organotion and Organozic Reagents

  摘要：

  Pyrimidinyl triflates have been synthesized from pyrimidinones using triflic anhydride in the presence of triethylamine. The triflates, in the pyrimidine electrophilic positions, are versatile intermediates for substitution reactions. Carbon substituents are readily introduced in any position by Pd-catalyzed coupling reactions between pyrimidinyl triflates and aryl- or alkenyltin or with the corresponding organozinc reagents. Organozinc reagents are generally more reactive in coupling reaction and will effect the introduction of alkyl substituents.

  DOI：

  10.3987/com-93-s39

文献信息

• Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents
  作者：Bo Yang、Zhong-Xia Wang

  DOI：10.1021/acs.orglett.7b03145

  日期：2017.11.17

  Cross-coupling of (hetero)arylthiols with arylzinc reagents via C–S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg2+ and Li+ ions were demonstrated to facilitate the reaction.

  （杂）芳基硫醇与芳基锌试剂通过C–S裂解的交叉偶联是在无过渡金属的条件下进行的。该反应显示出广泛的底物范围和高官能团耐受性。富电子和不足的（杂）芳基硫醇和芳基锌试剂可用于该转化中。已证明Mg 2+和Li +离子可促进反应。
• A convenient method for the preparation of highly substituted pyrimidines: Synthesis of tri‐ and tetra‐subsituted pyrimidines from 1,3‐dicarbonyl compounds and <i>N,N,N</i> ‐tris‐(trimethylsilyl)amidines
  作者：Usha Ghosh、John A. Katzenellenbogen

  DOI：10.1002/jhet.5570390542

  日期：2002.9

  A modification of the Pinner pyrimidine synthesis has been developed that utilizes trimethylsilyl amidines and results in greatly improved yield of highly substituted pyrimidines.

  已开发出使用三甲基甲硅烷基synthesis的Pinner嘧啶合成的修饰方法，可大大提高高度取代的嘧啶的收率。
• Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors
  申请人：BASF SE

  公开号：US20160249615A1

  公开（公告）日：2016-09-01

  The present invention relates to the use of strobilurine type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing a mutation in the mitochondrial cytochrome b gene conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, to plant health applications, and to seeds coated with at least one such compound.

  本发明涉及使用式I的异菌脲类化合物及其N-氧化物和盐来对抗带有线粒体细胞色素b基因突变从而对Qo抑制剂产生抗性的植物病原真菌，并涉及对抗这种真菌的方法。本发明还涉及新化合物、制备这些化合物的方法、包含至少一种这样的化合物的组合物、植物健康应用以及至少涂覆有一种这样的化合物的种子。
• STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI
  申请人：BASF SE

  公开号：US20160122327A1

  公开（公告）日：2016-05-05

  The present invention relates to novel strobilurine type compounds I, processes for preparing these compounds, a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi, to compositions comprising at least one such compound, to plant health applications, and to seeds coated with at least one such compound.

  本发明涉及新型的链霉菌素类化合物I，制备这些化合物的方法，化合物I及/或其农业有用的盐用于控制植物病原真菌，至少包含一种这样的化合物的组合物，植物健康应用，以及至少涂覆一种这样的化合物的种子。
• Strobilurin Type Compounds for Combating Phytopathogenic Fungi
  申请人：BASF SE

  公开号：US20160145202A1

  公开（公告）日：2016-05-26

  The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one such compound.

  本发明涉及新型的环丙基丙烯酸酯类化合物，涉及至少含有该化合物的组合物，涉及用于对抗植物病原真菌的方法，涉及使用该类化合物以及至少含有该类化合物的种子涂层。