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1-(4-aminophenyl)-3-cyclopropylurea | 1000931-26-9

中文名称
——
中文别名
——
英文名称
1-(4-aminophenyl)-3-cyclopropylurea
英文别名
——
1-(4-aminophenyl)-3-cyclopropylurea化学式
CAS
1000931-26-9
化学式
C10H13N3O
mdl
MFCD09802241
分子量
191.233
InChiKey
CMXMMZLCDAGGNQ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    351.9±34.0 °C(Predicted)
  • 密度:
    1.24±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1
  • 重原子数:
    14
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.3
  • 拓扑面积:
    67.2
  • 氢给体数:
    3
  • 氢受体数:
    2

反应信息

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文献信息

  • UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE-QUINAZOLINE AND -LINKED DIOXANE-QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF
    申请人:Beijing Scitech-MQ Pharmaceuticals Limited
    公开号:EP3590941A1
    公开(公告)日:2020-01-08
    The present invention relates to a urea-substituted aromatic ring-linked dioxane-quinazoline compound of Formula (I) and a urea-substituted aromatic ring-linked dioxane-quinoline, or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in Formula (I) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.
    本发明涉及一种式(I)的尿素取代芳香环联结的二氧六环喹唑啉化合物以及一种尿素取代芳香环联结的二氧六环喹喹啉,或其药用可接受的盐或水合物。还提供了如式(I)所示的化合物的制备以及其药用可接受的盐和用作药物的用途。该药物用作酪氨酸激酶(例如VEGFR-2,C-RAF,B-RAF)的抑制剂,用于治疗酪氨酸激酶相关疾病。
  • Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
    申请人:BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    公开号:US10980809B2
    公开(公告)日:2021-04-20
    The present invention relates to a urea-substituted aromatic ring-linked dioxinoquinazoline and a urea-substituted aromatic ring-linked dioxinoquinoline of Formula (I), or a pharmaceutically acceptable salt thereof or a hydrate thereof. Also provided are the preparation of the compound as shown in Formula (I) and the pharmaceutically acceptable salt thereof and the use thereof as a drug. The drug is used as an inhibitor of tyrosine kinases (e.g., VEGFR-2, C-RAF, B-RAF) for treating tyrosine kinase-related diseases.
    本发明涉及一种脲取代的芳环连二噁喹唑啉和一种脲取代的芳环连二噁喹唑啉的式(I),或其药学上可接受的盐或其水合物。还提供了式 (I) 所示化合物及其药学上可接受的盐的制备方法及其作为药物的用途。该药物用作酪氨酸激酶(如VEGFR-2、C-RAF、B-RAF)的抑制剂,用于治疗酪氨酸激酶相关疾病。
  • Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase
    作者:Bing Yu、Li-da Tang、Yi-liang Li、Shu-hui Song、Xiao-liang Ji、Mu-sen Lin、Chun-Fu Wu
    DOI:10.1016/j.bmcl.2011.11.061
    日期:2012.1
    We report herein the design and synthesis of novel 4-aminoquinazoline derivatives based on the inhibitors of VEGFR-2 tyrosine kinases. The VEGFR-2 inhibitory activities of these newly synthesized compounds were also evaluated and compared with that of ZD6474. We found that most of target compounds had good inhibitory potency. In particular, compounds 1h, 1n and 1o were found to be 6, 2 and 2-fold more potent than the positive control ZD6474. The leading compound 1h also showed an in vivo activity against HepG2 human tumor xenograft model in BALB/c-nu mice. (C) 2011 Elsevier Ltd. All rights reserved.
  • Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases
    作者:William J. McClellan、Yujia Dai、Cele Abad-Zapatero、Daniel H. Albert、Jennifer J. Bouska、Keith B. Glaser、Terry J. Magoc、Patrick A. Marcotte、Donald J. Osterling、Kent D. Stewart、Steven K. Davidsen、Michael R. Michaelides
    DOI:10.1016/j.bmcl.2011.06.041
    日期:2011.9
    In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine residue with a thienopyrimidine moiety led to a series of potent and selective Aurora inhibitors.
    为了发现Aurora激酶抑制剂,HTS命中发现含有酰胺的吡咯并嘧啶化合物。用噻吩并嘧啶部分取代吡咯并嘧啶残基导致一系列有效的和选择性的Aurora抑制剂。
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