N²-<(tert-butoxy)carbonyl>-L-methionine phenyl ester | 37784-10-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N²-<(tert-butoxy)carbonyl>-L-methionine phenyl ester
• 英文别名: boc-L-methionine phenyl ester；N-t-Butoxycarbonylmethioninphenylester；N²-[(tert-butoxy)carbonyl]-L-methionine phenyl ester；Boc-methionine phenyl ester；phenyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoate
• CAS: 37784-10-4
• 化学式: C₁₆H₂₃NO₄S
• 分子量: 325.429
• InChiKey: UKACTSNCCFAMKC-ZDUSSCGKSA-N

物化性质

• 沸点：
  472.3±40.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N²-<(tert-butoxy)carbonyl>-L-methionine phenyl ester 在 tri-tert-butoxyaluminum hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 tert-butyl (S)-1-formyl-3-(methylthio)propylcarbamate
  参考文献：
  名称：

  通过还原相应的苯基酯制备Boc-氨基酸或肽醛

  摘要：

  描述了一种新的替代方法，用于制备氨基酸和肽醛，其基于将相应的苯基酯用三（叔丁氧基）氢化铝锂还原。

  DOI：

  10.1002/hlca.19940770117
• 作为产物：
  描述：

  N-[(1,1-二甲基乙氧基)羰基]-L-蛋氨酸 4-硝基苯基酯 在 苯酚 作用下， 生成 N²-<(tert-butoxy)carbonyl>-L-methionine phenyl ester
  参考文献：
  名称：

  Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria

  摘要：

  S-adenosyl-L-methionine (AdoMet) synthetase catalyzes the production of AdoMet, the major biological methyl donor and source of methylene, amino, ribosyl, and aminopropyl groups in the metabolism of all known organism. In addition to these essential functions, AdoMet can also serve as the precursor for two different families of quorum sensing molecules that trigger virulence in Gram-negative human pathogenic bacteria. The enzyme responsible for AdoMet biosynthesis has been cloned, expressed and purified from several of these infectious bacteria. AdoMet synthetase (MAT) from Neisseria meningitidis shows similar kinetic parameters to the previously characterized Escherichia coli enzyme, while the Pseudomonas aeruginosa enzyme has a decreased catalytic efficiency for its MgATP substrate. In contrast, the more distantly related MAT from Campylobacter jejuni has an altered quaternary structure and possesses a higher catalytic turnover than the more closely related family members. Methionine analogs have been examined to delineate the substrate specificity of these enzyme forms, and several alternative substrates have been identified with the potential to block quorum sensing while still serving as precursors for essential methyl donation and radical generation reactions. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.abb.2013.05.008

文献信息

• Enkephalin analogues
  申请人：——

  公开号：US04198398A1

  公开（公告）日：1980-04-15

  Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, methylene-imino and keto-methylene groups.

  具有与安啡肽或其多肽类似物相对应的结构化合物，其中安啡肽或类似物的一个或多个肽键由选择自二亚甲基、亚甲基-亚胺和酮基-亚甲基基团的相同或不同基团表示。
• Peach tree named ‘FLATBUZZ’
  申请人：AGRO SELECTIONS FRUITS

  公开号：USPP030731P3

  公开（公告）日：2019-07-23

  A new and distinct variety of white flat peach tree denominated ‘FLATBUZZ’ which have fruits with high eating quality and very long shelf life without alteration before and after harvesting, with a semi-sweet white flesh, with a red pigmentation into and around the stone cavity, and an attractive skin with a high percentage of purple red blush on skin surface, on an orange red background.

  一种新的独特的白色扁桃树品种，命名为“FLATBUZZ”，其果实具有高品质和长久的货架寿命，采摘前后不会发生变化，果肉为半甜的白色，核腔内和周围有红色色素，果皮上有高比例的紫红色晕染，在橙红色背景上非常吸引人。
• Activation of a carboxy group by dialkyl pyrocarbonates. Synthesis of symmetrical anhydrides and aryl esters of N-protected amino acids using di-tert-butyl pyrocarbonate as condensing reagent
  作者：V. F. Pozdnev、M. Yu. Chernaya

  DOI：10.1007/bf00575762

  日期：——
• Peptide Coupling Reagents; VIII. A High Yield Preparation of Phenyl Esters of Amino Acids using Benzotriazolyloxytris[dimethylamino]phosphonium Hexafluorophosphate (BOP Reagent)
  作者：Bertrand CASTRO、Geneviève EVIN、Claude SELVE、René SEYER

  DOI：10.1055/s-1977-24420

  日期：——