1,3-bis<<<6-(1-butyrylamino)pyrid-2-yl>amino>carbonyl>-5-nitrobenzene | 129648-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis<<<6-(1-butyrylamino)pyrid-2-yl>amino>carbonyl>-5-nitrobenzene
• CAS: 129648-69-7
• 化学式: C₂₆H₂₇N₇O₆
• 分子量: 533.544
• InChiKey: IGQWMFJBJUQZAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.37
• 重原子数：
  39.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  185.32
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  5-硝基异酞酰氯 在 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 1,3-bis<<<6-(1-butyrylamino)pyrid-2-yl>amino>carbonyl>-5-nitrobenzene
  参考文献：
  名称：

  Transition-state stabilization and molecular recognition: acceleration of phosphoryl-transfer reactions by an artificial receptor

  摘要：

  An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with P-31 NMR methods show that the receptor causes up to a 10-fold accleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.

  DOI：

  10.1021/ja00182a017

文献信息

• Transition-state stabilization and molecular recognition: acceleration of phosphoryl-transfer reactions by an artificial receptor
  作者：Paolo Tecilla、Suk Kyu Chang、Andrew D. Hamilton

  DOI：10.1021/ja00182a017

  日期：1990.12

  An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with P-31 NMR methods show that the receptor causes up to a 10-fold accleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.