3-(di(2-methoxyphenyl)phosphanyl)propionic acid | 1332313-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(di(2-methoxyphenyl)phosphanyl)propionic acid
• 英文别名: 3-Bis(2-methoxyphenyl)phosphanylpropanoic acid；3-bis(2-methoxyphenyl)phosphanylpropanoic acid
• CAS: 1332313-86-6
• 化学式: C₁₇H₁₉O₄P
• 分子量: 318.309
• InChiKey: XZVCFKKELOWTFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(di(2-methoxyphenyl)phosphanyl)propionic acid 、 potassium platinum(II) chloride*xH2O=Kaliumplatin(II)-chlorid*xH2O 在 KOH 作用下， 以 水 为溶剂， 以72%的产率得到[PtCl(κ2-3-(di(2-methoxyphenyl)phosphanyl)propionate)(κ-3-(di(2-methoxyphenyl)phosphanyl)propionic acid)]
  参考文献：
  名称：

  First microwave-assisted synthesis of an electron-rich phosphane and its coordination chemistry with platinum(II) and palladium(II)

  摘要：

  The P-O ligand 3-(di(2-methoxyphenyl)phosphanyl) propionic acid (HL) was synthesized by a microwave-assisted reaction of a secondary phosphane. The coordination of HL to Pt-II yielded the neutral mononuclear complex trans-[PtCl(kappa(2)-P,O-L)(kappa-P-HL)] (1), while the reaction of PdClMe(eta(4)-COD) (COD = 1,4-cyclooctadiene) with HL in the presence of NEt3 gave the anionic Pd-II compound of the formula (HNEt3)[PdClMe(kappa(2)-P,O-L)] (2). Upon crystallization of the latter compound the neutral chloridebridged dimetallic compound cis-[Pd(mu-Cl)Me(HL)](2) (3) was obtained. HL, 1 and 3 center dot CH2Cl2 have been characterized by single crystal X-ray structure analyses. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.05.020
• 作为产物：
  描述：

  在 sodium methylate 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以41%的产率得到3-(di(2-methoxyphenyl)phosphanyl)propionic acid
  参考文献：
  名称：

  First microwave-assisted synthesis of an electron-rich phosphane and its coordination chemistry with platinum(II) and palladium(II)

  摘要：

  The P-O ligand 3-(di(2-methoxyphenyl)phosphanyl) propionic acid (HL) was synthesized by a microwave-assisted reaction of a secondary phosphane. The coordination of HL to Pt-II yielded the neutral mononuclear complex trans-[PtCl(kappa(2)-P,O-L)(kappa-P-HL)] (1), while the reaction of PdClMe(eta(4)-COD) (COD = 1,4-cyclooctadiene) with HL in the presence of NEt3 gave the anionic Pd-II compound of the formula (HNEt3)[PdClMe(kappa(2)-P,O-L)] (2). Upon crystallization of the latter compound the neutral chloridebridged dimetallic compound cis-[Pd(mu-Cl)Me(HL)](2) (3) was obtained. HL, 1 and 3 center dot CH2Cl2 have been characterized by single crystal X-ray structure analyses. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.05.020