trimethyl-[(E,4R)-4-methyl-5-phenylmethoxypent-2-enyl]silane | 190134-29-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trimethyl-[(E,4R)-4-methyl-5-phenylmethoxypent-2-enyl]silane
• CAS: 190134-29-3
• 化学式: C₁₆H₂₆OSi
• 分子量: 262.467
• InChiKey: IKNFIHGETAYJDL-XVJNWHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.73
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯甲醛 、 trimethyl-[(E,4R)-4-methyl-5-phenylmethoxypent-2-enyl]silane 在 四氯化锡 作用下， 生成 (Z,1R,5R)-5-methyl-1-phenyl-6-phenylmethoxyhex-3-en-1-ol 、 (1S,5R,3Z)-6-benzyloxy-5-methyl-1-phenylhex-3-en-1-ol 、
  参考文献：
  名称：

  Remote asymmetric induction in reactions of 5-alkoxyalk-2-enylsilanes and aldehydes promoted by tin(IV) chloride

  摘要：

  Following observations on remote asymmetric induction using allylstannanes, 5-benzyloxy-4-methylpent-2-enylsilanes are also found to react with aldehydes with modest levels of 1,5-induction after treatment with tin(IV) chloride. Transmetallation to give intermediate allyltin trihalides may be involved. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00358-4
• 作为产物：
  描述：

  (2S)-3-(benzyloxy)-2-methylpropanal 在 disodium hydrogenphosphate 、 sodium amalgam 、 正丁基锂 、 sodium 、 汞 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 trimethyl-[(E,4R)-4-methyl-5-phenylmethoxypent-2-enyl]silane
  参考文献：
  名称：

  Remote asymmetric induction in reactions of 5-alkoxyalk-2-enylsilanes and aldehydes promoted by tin(IV) chloride

  摘要：

  Following observations on remote asymmetric induction using allylstannanes, 5-benzyloxy-4-methylpent-2-enylsilanes are also found to react with aldehydes with modest levels of 1,5-induction after treatment with tin(IV) chloride. Transmetallation to give intermediate allyltin trihalides may be involved. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00358-4

文献信息

• Remote asymmetric induction in reactions of 5-alkoxyalk-2-enylsilanes and aldehydes promoted by tin(IV) chloride
  作者：Christopher T. Brain、Eric J. Thomas

  DOI：10.1016/s0040-4039(97)00358-4

  日期：1997.3

  Following observations on remote asymmetric induction using allylstannanes, 5-benzyloxy-4-methylpent-2-enylsilanes are also found to react with aldehydes with modest levels of 1,5-induction after treatment with tin(IV) chloride. Transmetallation to give intermediate allyltin trihalides may be involved. (C) 1997 Elsevier Science Ltd.