3-乙酰氧基-4-羟基-苯甲酸 | 104056-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-乙酰氧基-4-羟基-苯甲酸
• 英文名称: 3-acetoxy-4-hydroxy-benzoic acid
• 英文别名: 3-Acetoxy-4-hydroxy-benzoesaeure；3-Acetyl-protocatechusaeure；Monoacetylprotocatechusaeure；3-Acetyloxy-4-hydroxybenzoic acid
• CAS: 104056-02-2
• 化学式: C₉H₈O₅
• 分子量: 196.16
• InChiKey: NWTNUIDDZJWZQC-UHFFFAOYSA-N

物化性质

• 熔点：
  202-203 °C
• 沸点：
  386.3±37.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-乙酰氧基-4-羟基-苯甲酸 在 吡啶 、 ammonium hydroxide 、 氯仿 、 丙酮 作用下， 生成 3-benzoyloxy-4-hydroxy-benzoic acid methyl ester
  参考文献：
  名称：

  Molecular Farming in Plants: A Current Perspective

  摘要：

  DOI：

  10.1007/bf03263099
• 作为产物：
  描述：

  异黄樟素 在 氢氧化钾 、 sodium acetate 作用下， 生成 3-乙酰氧基-4-羟基-苯甲酸
  参考文献：
  名称：

  Ciamician; Silber, Chemische Berichte, 1892, vol. 25, p. 1472

  摘要：

  DOI：

文献信息

• A method for producing adapalene gels
  申请人：Galderma Research & Development

  公开号：EP2065032A1

  公开（公告）日：2009-06-03

  The invention relates to a method for producing an adapalene aqueous gel, which method comprises preparing a gelling medium A by mixing water and propylene glycol and adding a gelling agent; preparing an adapalene medium B by dispersing adapalene in water, in the presence of a surfactant; adding the adapalene medium B to the gelling medium A ; and adjusting the pH to about 4.7-5.

  本发明涉及一种生产阿达帕林水凝胶的方法，该方法包括通过混合水和丙二醇并添加胶凝剂制备胶凝介质 A；在表面活性剂存在的情况下，通过将阿达帕林分散在水中制备阿达帕林介质 B；将阿达帕林介质 B 添加到胶凝介质 A 中；以及将 pH 值调节至约 4.7-5。
• SOME NEW DERIVATIVES OF PROTOCATECHUIC ACID FORMED FROM SAFROL AND TWO EXAMPLES OF THE REARRANGEMENT OF THE ACYL GROUP
  作者：Kashichi Ono、Minoru Imoto

  DOI：10.1246/bcsj.10.323

  日期：1935.8
• La numération plaquettaire peut permettre de prédire le temps de saignement chez des parturientes atteintes d’hypertension et de pré-éclampsie
  作者：R. J. McDonagh、J. G. Ray、R. F. Burrows、E. A. Burrows、M. J. Vermeulen

  DOI：10.1007/bf03016833

  日期：2001.6

  Background: Anesthesiologists often require laboratory data to estimate the bleeding risk among hypertensive pregnant women prior to administering regional anesthesia. Many rely on the bleeding time (BT) in making this determination. We examined whether the platelet count can adequately predict BT among a group of hypertensive parturients.Methods: This retrospective subgroup analysis, taken from a cohort of 2051 hypertensive pregnant women, comprises 87 individuals who underwent both a BT and platelet count prior to delivery. We calculated the correlation between the platelet count and BT at three platelet cut-off points with respect to prolonged BT of eight minutes or more.Results: There was a significant negative correlation between platelet count at delivery and BT [r= -0.45, 95% confidence interval (CI) -0.26 to -0.60; P <0.0001]. All three platelet cut-off points had a sensitivity of less than 66% with negative predictive values below 75% for an abnormal BT: A platelet count greater than or equal to 75 x 10(9)/L was specific for the presence of an abnormal BT (specificity 97.8%, 95% CI 91.7-100.0), with a positive predictive value of 95.5% (95% CI 83.1 - 100.0) and a positive likelihood ratio of 24 (95% CI 3.3- 168).Conclusions: In a group of hypertensive parturients, the platelet count appears to be very! specific for predicting a prolonged BT; The platelet count may aid the anesthesiologist in determining the risk of bleeding from regional anesthesia. Given the study's potential for bias future research is needed to validate these findings.
• Brass; Smrcek, Chemische Berichte, 1942, vol. 75, p. 1680,1683
  作者：Brass、Smrcek

  DOI：——

  日期：——
• COMPOSITION COMPRISING AT LEAST ONE NAPHTHOIC ACID DERIVATIVE AND AT LEAST ONE COMPOUND OF POLYURETHANE POLYMER TYPE OR DERIVATIVES THEREOF, PREPARATION PROCESSES THEREFOR AND USES THEREOF
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1933827A2

  公开（公告）日：2008-06-25