2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diyl diacetate | 900782-31-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diyl diacetate
• 英文别名: 1,3-di-O-acetyl-2-O-tetrahydropyranylpropane-1,2,3-triol；[3-Acetyloxy-2-(oxan-2-yloxy)propyl] acetate
• CAS: 900782-31-2
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.287
• InChiKey: GWCPDZCPXHVXRC-UHFFFAOYSA-N

物化性质

• 沸点：
  355.9±42.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diyl diacetate 在 吡啶 、 氨 、 caesium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1H-咪唑-1-丙醇
  参考文献：
  名称：

  [18F]-氟咪唑标记前体的新合成

  摘要：

  [18F]-氟米尼唑是最广泛用于肿瘤缺氧成像的放射性药物。[18F]-氟咪唑的前体是从 1,3-二溴-2-丙醇通过 5 个步骤从可用材料和简单的纯化步骤制备的。该合成的总产率为18%。版权所有 © 2005 John Wiley & Sons, Ltd.

  DOI：

  10.1002/jlcr.1001
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 在 4-甲基苯磺酸吡啶 、 四丁基碘化铵 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 2-(tetrahydro-2H-pyran-2-yloxy)propane-1,3-diyl diacetate
  参考文献：
  名称：

  Multidentate ¹⁸F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA)

  摘要：

  beta-Amyloid plaques (A beta plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the A beta plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of F-18 styrylpyridine derivatives with high molecular weights for selectively targeting A beta plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The styrylpyridine derivatives, 8a-c, display high binding affinities and specificity to A beta plaques (K-i = 2.87, 3.24, and 7.71 nM, respectively). In vitro autoradiography of [F-18]8a shows labeling of beta-amyloid plaques associated with blood vessel walls in human brain sections of subjects with CAA and also in the tissue of AD brain sections. The results suggest that [F-18]8a may be a useful PET imaging agent for selectively detecting A beta plaques associated with cerebral vessels in the living human brain.

  DOI：

  10.1021/jm2009106

文献信息

• Multidentate ¹⁸F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA)
  作者：Zhihao Zha、Seok Rye Choi、Karl Ploessl、Brian P. Lieberman、Wenchao Qu、Franz Hefti、Mark Mintun、Daniel Skovronsky、Hank F. Kung

  DOI：10.1021/jm2009106

  日期：2011.12.8

  beta-Amyloid plaques (A beta plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the A beta plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of F-18 styrylpyridine derivatives with high molecular weights for selectively targeting A beta plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The styrylpyridine derivatives, 8a-c, display high binding affinities and specificity to A beta plaques (K-i = 2.87, 3.24, and 7.71 nM, respectively). In vitro autoradiography of [F-18]8a shows labeling of beta-amyloid plaques associated with blood vessel walls in human brain sections of subjects with CAA and also in the tissue of AD brain sections. The results suggest that [F-18]8a may be a useful PET imaging agent for selectively detecting A beta plaques associated with cerebral vessels in the living human brain.
• A new synthesis of the labeling precursor for [18F]-fluoromisonidazole
  作者：Tom C. H. Adamsen、John R. Grierson、Kenneth A. Krohn

  DOI：10.1002/jlcr.1001

  日期：2005.10.30

  [18F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [18F]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%. Copyright © 2005 John Wiley & Sons, Ltd.

  [18F]-氟米尼唑是最广泛用于肿瘤缺氧成像的放射性药物。[18F]-氟咪唑的前体是从 1,3-二溴-2-丙醇通过 5 个步骤从可用材料和简单的纯化步骤制备的。该合成的总产率为18%。版权所有 © 2005 John Wiley & Sons, Ltd.