undecane-1,1,11-tricarboxylic acid | 53227-26-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: undecane-1,1,11-tricarboxylic acid
• 英文别名: Undecan-1,1,11-tricarbonsaeure；Undecan-α.α.λ-tricarbonsaeure；2-Methylsaeure-tridecandisaeure；2-Carboxy-tridecan-disaeure；1,1,11-Undecanetricarboxylic acid
• CAS: 53227-26-2
• 化学式: C₁₄H₂₄O₆
• 分子量: 288.341
• InChiKey: LKPNWMVELYVPMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  undecane-1,1,11-tricarboxylic acid 生成 十三烷二酸
  参考文献：
  名称：

  Free-radical addition of alcohols and acids to 10-undecenoic esters, 10-undecen-1-Ol, and 10-undecenyl acetate

  摘要：

  DOI：

  10.1007/bf00906006
• 作为产物：
  描述：

  undecane-1,1,11-tricarboxylic acid triethyl ester 在 氢氧化钾 作用下， 生成 undecane-1,1,11-tricarboxylic acid
  参考文献：
  名称：

  Sur quelques polypeptides nouveaux

  摘要：

  摘要作者制备了由以下外消旋α-氨基酸衍生的多肽： α-氨基酸是通过 NH3 对α-溴酸的作用得到的，第二种是通过变体得到的：2-十三烷二酸碳酸是从其乙基三酯中得到的，将其溴化，然后用 NH3 处理；氨基三酸经 dC 羧化后得到 dl-氨基-2-十三烷二酸；后者用苯甲醇进行单雌溴化。通过氧氯化碳的直接作用，我们从氨基酸衍生出相应的 Leuchs 衍生物：十六烷基-4-恶唑烷二酮-2,5 和二苄基-Bne-4-恶唑烷二酮-2,5 碳酸苄酯。在后者和 1-溴-1-undbcanolic 酸上观察到了二态性。在碱性引发剂的作用下，二酮-2,5-恶唑烷在溶液中聚合。通过沉淀分馏后，对聚二氮-2-辛二烷酸苯溶液的粘度以及光散射的研究表明，随着浓度的增加，会形成聚合体。

  DOI：

  10.1002/pol.1958.1203012112

文献信息

• [EN] METHODS OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GROWTH DIFFERENTIATION FACTOR 15 (GDF-15)<br/>[FR] MÉTHODES DE TRAITEMENT OU D'AMÉLIORATION DE TROUBLES MÉTABOLIQUES À L'AIDE DU FACTEUR-15 DE CROISSANCE ET DE DIFFÉRENCIATION (GDF-15)
  申请人：NOVARTIS AG

  公开号：WO2017109706A1

  公开（公告）日：2017-06-29

  The disclosure relates to the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), as well as end-stage liver disease, hepatic steatosis (fatty liver), liver fibrosis, liver inflammation, liver cirrhosis, primary biliary cirrhosis (PBC), and hepatocellular carcinoma (HCC), by administering to a subject in need a GDF15 protein or a functional variant, mutation, fusion, or conjugate thereof, and to pharmaceutical compositions that contain the same.

  该披露涉及通过向需要的受试者施用GDF15蛋白或其功能变体、突变体、融合物或结合物，以及含有相同成分的药物组合物，治疗非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH），以及晚期肝病、肝脂肪变性（脂肪肝）、肝纤维化、肝炎、肝硬化、原发性胆汁性肝硬化（PBC）和肝细胞癌（HCC）。
• NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES
  申请人：BARNES David Weninger

  公开号：US20160030585A1

  公开（公告）日：2016-02-04

  The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R 1 , R 2 , R 3 , R 4 , Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种共轭物，其包括通过连接剂与脂肪酸连接的生物分子，其中所述的脂肪酸具有以下的化学式A1、A2或A3：其中，R1、R2、R3、R4、Ak、n、m和p在此定义。本发明还涉及一种制造GDF15共轭物等本发明共轭物的方法，以及其治疗用途，如治疗或预防代谢性疾病或疾病、2型糖尿病、肥胖症、胰腺炎、血脂异常、酒精性和非酒精性脂肪肝病/脂肪性肝炎和其他进行性肝脏疾病、胰岛素抵抗、高胰岛素血症、葡萄糖不耐受、高血糖、代谢综合征、高血压、心血管疾病、动脉粥样硬化、周围动脉疾病、中风、心力衰竭、冠心病、糖尿病并发症（包括但不限于慢性肾脏疾病）、神经病变、胃轻瘫和其他代谢性疾病。本发明还提供了药理活性剂的组合和制药组合物。
• Method for the preparation of a printing plate
  申请人：EASTMAN KODAK COMPANY

  公开号：EP1386729A1

  公开（公告）日：2004-02-04

  The invention relates to a method for the preparation of a printing plate comprises inkjet printing an oleophilic image on a surface of a support by applying to the support an aqueous solution or aqueous colloidal dispersion of an oleophilising compound on the surface of the support and drying the applied solution or dispersion, such that on drying the area of the surface to which the solution or dispersion was applied becomes lithographic ink-accepting, characterised in that the oleophilising compound has the chemical structure         MO2C-(CHR)1-(CHR')m-(CHR")n-CO2M or         MO2C-(CHR)l-(CHR')m-(CHR")n-SO3M wherein each M is the same or different and is independently selected from H or a cation; each of l, m and n independently is 0 or 1, provided that l+m+n = at least 1; each of R, R' and R" independently is -H, -B or -L-B; L is a linking group selected from alkylene, alkyleneoxy, thio, sulfonyl, sulfinyl, sulfoxyl, amido, alkylamido, oxyamido, alkylcarbamoyl carbamoyl, sulfonylamido, aminosulfonyl, aminosufonylamido, hydrazinylsufonyl, carboxyl, oxycarbonyl, carbonyl, carboxyhydrazinyl, amino, thiocarbonyl, sulfamoylamino, sulfamoyl, thiocarbamoyl, any one of said linking groups being substituted or unsubstituted; and B is a hydrophobic group comprising 8 or more carbon atoms, provided that at least one of R, R' and R" is present and has the structure -B or -L-B.

  本发明涉及一种制备印版的方法，包括在支撑物表面喷墨打印亲油性图像，方法是在支撑物表面涂抹亲油性化合物的水溶液或水性胶体分散液，并将涂抹的溶液或分散液干燥，从而使涂抹溶液或分散液的表面区域在干燥后具有平版印刷油墨接受性，其特征在于亲油性化合物具有以下化学结构 MO2C-(CHR)1-(CHR')m-(CHR")n-CO2M 或 MO2C-(CHR)l-(CHR')m-(CHR")n-SO3M 其中 每个 M 相同或不同，且独立地选自 H 或阳离子； 每个 l、m 和 n 独立地为 0 或 1、 条件是 l+m+n = 至少 1； R、R'和 R "各自独立地为-H、-B 或-L-B； L 是一个连接基团，选自亚烷基、亚烷氧基、硫基、磺酰基、亚砜基、亚砜基、氨基、烷基氨基、氧氨基、烷基氨基甲酰基氨基甲酰基、磺酰氨基、氨基磺酰基、氨基磺酰基、氨基磺酰基氨基、肼基磺酰基、肼基磺酰基、羧基、氧羰基、羰基、羧基肼基、氨基、硫代羰基、氨基磺酰基、氨基磺酰基、硫代氨基磺酰基，上述连接基团中的任一基团可被取代或未被取代；和 B 是由 8 个或更多碳原子组成的疏水基团，条件是 R、R'和 R "中至少有一个具有-B 或-L-B 结构。
• FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES
  申请人：Novartis AG

  公开号：EP3988170A1

  公开（公告）日：2022-04-27

  The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formula A1: wherein R1, R2, R3, n and m are defined herein. The invention also relates to uses of the fatty acids in providing said conjuage. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种共轭物，该共轭物包括通过连接剂与脂肪酸连接的生物大分子，其中脂肪酸具有下式 A1： 其中 R1、R2、R3、n 和 m 在本文中定义。本发明还涉及脂肪酸在提供所述结合物中的用途。本发明还涉及制造本发明结合物（如 GDF15 结合物）的方法及其治疗用途，如治疗或预防代谢紊乱或疾病、2 型糖尿病、肥胖症、胰腺炎、血脂异常、酒精性和非酒精性脂肪肝/骨转移性肝炎和其他进行性肝病、胰岛素抵抗、高胰岛素血症、葡萄糖不耐受、高血糖、代谢综合征、高血压、心血管疾病、动脉粥样硬化、外周动脉疾病、中风、心力衰竭、冠心病、糖尿病并发症（包括但不限于慢性肾病）、神经病变、胃痉挛和其他代谢紊乱。本发明进一步提供了药理活性制剂和药物组合物的组合。
• Polyester carbonate and a data carrier therefrom
  申请人：——

  公开号：US20030104234A1

  公开（公告）日：2003-06-05

  A copolyester carbonate especially suitable for the preparation of machine readable data carriers is disclosed. The inventive copolyester carbonate contains structural units derived from acids according to formula (I), 1 wherein D denotes a mixture of divalent hydrocarbon radicals substantially corresponds to one or more of 2 wherein E 1 , E 2 , E 3 and E 4 denote one of the substituents —(CH 2 ) i —, —(CH 2 ) j —, —(CH 2 ) k CH 3 and —(CH 2 ) 1 CH 3 , and a, b, c, d, e, f, g, h, i, j, k, l, m, n, o and p independently of one another denote an integer between 1 and 10.

  本发明公开了一种特别适用于制备机器可读数据载体的碳酸共聚酯。本发明的碳酸共聚聚酯含有由酸衍生的结构单元，其结构单元按式（I）表示、 1 其中 D 表示二价烃基的混合物，基本上相当于以下一种或多种 2 其中 E 1 , E 2 , E 3 和 E 4 表示一个取代基-(CH 2 ) i -、-(CH 2 ) j -，-(CH 2 ) k CH 3 和-(CH 2 ) 1 CH 3 其中 a、b、c、d、e、f、g、h、i、j、k、l、m、n、o 和 p 分别表示 1 到 10 之间的整数。