N'-(4-nitrophenyl)hydrazine carboxylic acid butyl ester | 42274-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(4-nitrophenyl)hydrazine carboxylic acid butyl ester
• 英文别名: butyl N-(4-nitroanilino)carbamate
• CAS: 42274-90-8
• 化学式: C₁₁H₁₅N₃O₄
• 分子量: 253.258
• InChiKey: NAIRAAXABANCGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-Butylnonan-5-yl 4-methylbenzenesulfonate 、 N'-(4-nitrophenyl)hydrazine carboxylic acid butyl ester 、 二氧化碳 在 苄基三甲基氢氧化铵 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以88%的产率得到N'-phenylhydrazine carboxylic acid 1,1-dibutylpentyl ester
  参考文献：
  名称：

  Triton-B-Catalyzed, Efficient, One-Pot Synthesis of Carbazates Through Alcoholic Tosylates

  摘要：

  A quick, efficient, one-pot synthesis of carbazates was accomplished in high yields by the reaction of various tosylates of primary, secondary, and tert alcohols, with a variety of substituted hydrazines using the benzyltrimethylammonium hydroxide (Triton-B)/CO2 system. The reaction conditions are mild with simpler workup procedures than the reported methods.

  DOI：

  10.1080/00397910802269259
• 作为产物：
  描述：

  对甲苯磺酸正丁酯 、 二氧化碳 、 4-硝基苯肼 在 苄基三甲基氢氧化铵 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以85%的产率得到N'-(4-nitrophenyl)hydrazine carboxylic acid butyl ester
  参考文献：
  名称：

  Triton-B-Catalyzed, Efficient, One-Pot Synthesis of Carbazates Through Alcoholic Tosylates

  摘要：

  A quick, efficient, one-pot synthesis of carbazates was accomplished in high yields by the reaction of various tosylates of primary, secondary, and tert alcohols, with a variety of substituted hydrazines using the benzyltrimethylammonium hydroxide (Triton-B)/CO2 system. The reaction conditions are mild with simpler workup procedures than the reported methods.

  DOI：

  10.1080/00397910802269259

文献信息

• An efficient one-pot synthesis of carbazates and dithiocarbazates through the corresponding alcohols using Mitsunobu’s reagent
  作者：A. K. Chaturvedi、D. Chaturvedi、N. Mishra、V. Mishra

  DOI：10.1007/bf03249073

  日期：2011.6

  A novel Mitsunobu-based protocol has been developed for the synthesis of carbazates and dithiocarbazates through the variety of corresponding primary, secondary and tertiary alcohols and various kinds of substituted hydrazines using Mitsunobu’s reagent and CO2/CS2 system, in good to excellent yields.

  使用Mitsunobu的试剂和CO 2 / CS 2系统，已开发出一种新颖的基于Mitsunobu的新方案，可通过使用Mitsunobu的试剂和CO 2 / CS 2系统通过各种相应的伯醇，仲醇和叔醇以及各种取代的肼来合成氨基甲酸酯和二硫代氨基甲酸酯。
• Triton-B catalyzed, efficient one-pot synthesis of carbazates
  作者：Devdutt Chaturvedi、Amit K. Chaturvedi、Nisha Mishra、Virendra Mishra

  DOI：10.1007/s00706-008-0955-8

  日期：2008.12

  A quick and efficient, one-pot synthesis of carbazates was accomplished in high yields by the reaction of various primary, secondary, and tertiary alkyl halides with a variety of substituted hydrazines using the benzyltrimethylammonium hydroxide (Triton-B)/CO2 system. The reaction conditions are mild with simpler work-up procedures than the reported methods.
• Triton-B-Catalyzed, Efficient, One-Pot Synthesis of Carbazates Through Alcoholic Tosylates
  作者：Devdutt Chaturvedi、Amit K. Chaturvedi、Nisha Mishra、Virendra Mishra

  DOI：10.1080/00397910802269259

  日期：2008.10.28

  A quick, efficient, one-pot synthesis of carbazates was accomplished in high yields by the reaction of various tosylates of primary, secondary, and tert alcohols, with a variety of substituted hydrazines using the benzyltrimethylammonium hydroxide (Triton-B)/CO2 system. The reaction conditions are mild with simpler workup procedures than the reported methods.