4-iodoacetamidodipicolinic acid dimethylester | 150730-43-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-iodoacetamidodipicolinic acid dimethylester
• 英文别名: Dimethyl 4-[(2-iodoacetyl)amino]pyridine-2,6-dicarboxylate；dimethyl 4-[(2-iodoacetyl)amino]pyridine-2,6-dicarboxylate
• CAS: 150730-43-1
• 化学式: C₁₁H₁₁IN₂O₅
• 分子量: 378.123
• InChiKey: PSXNYMPPZGKBPF-UHFFFAOYSA-N

物化性质

• 沸点：
  553.7±50.0 °C(predicted)
• 密度：
  1.797±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  94.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-iodoacetamidodipicolinic acid dimethylester 生成 4-iodoacetamidodipicolinic acid
  参考文献：
  名称：

  A novel reagent for labelling macromolecules with intensely luminescent lanthanide complexes

  摘要：

  A novel bifunctional chelator, 4-iodoacetamidodipicolinicacid, has been synthesized in three steps starting with chelidamic acid, and used to prepare protein conjugates that form stable and intensely luminescent complexes with Tb(III) and Eu(III). The excited state lifetime of Tb(III) complexes with this reagent was 1.25 ms, permitting its use for ultrasensitive time-resolved luminescence assays.

  DOI：

  10.1016/s0040-4039(00)60512-9
• 作为产物：
  描述：

  4-氯吡啶-2,6-二羧酸 在 硫酸 盐酸 、 ammonium hydroxide 作用下， 反应 25.0h， 生成 4-iodoacetamidodipicolinic acid dimethylester
  参考文献：
  名称：

  A novel reagent for labelling macromolecules with intensely luminescent lanthanide complexes

  摘要：

  A novel bifunctional chelator, 4-iodoacetamidodipicolinicacid, has been synthesized in three steps starting with chelidamic acid, and used to prepare protein conjugates that form stable and intensely luminescent complexes with Tb(III) and Eu(III). The excited state lifetime of Tb(III) complexes with this reagent was 1.25 ms, permitting its use for ultrasensitive time-resolved luminescence assays.

  DOI：

  10.1016/s0040-4039(00)60512-9