leucyl=>glycyl=>leucine | 19408-47-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: leucyl=>glycyl=>leucine
• 英文别名: Leucyl=>glycyl=>leucin；Leucyl-glycyl-leucin；2-[[2-[(2-azaniumyl-4-methylpentanoyl)amino]acetyl]amino]-4-methylpentanoate
• CAS: 19408-47-0
• 化学式: C₁₄H₂₇N₃O₄
• 分子量: 301.386
• InChiKey: HYIFFZAQXPUEAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  leucyl=>glycyl=>leucine 在 盐酸 作用下， 生成 leucyl=>glycyl=>leucine methylamide
  参考文献：
  名称：

  Abderhalden; Schweitzer, Fermentforschung, 1929, vol. 11, p. 533

  摘要：

  DOI：
• 作为产物：
  描述：

  N-[N-(2-bromo-4-methyl-valeryl)-glycyl]-leucine 在 氨 、 水 作用下， 生成 leucyl=>glycyl=>leucine
  参考文献：
  名称：

  Fischer,E.; Steingroever, Justus Liebigs Annalen der Chemie, 1907, vol. 356, p. 176

  摘要：

  DOI：

文献信息

• Cytostatic-glycoconjugates having specifically cleavable linking units
  申请人：——

  公开号：US20020173452A1

  公开（公告）日：2002-11-21

  The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to specific carbohydrate moeities via preferred linking units which can be selevtively cleaved by enzymes such as metallo matrixproteases (MMPs), elastase or cathepsines, i.e. by enzymes which can especially be found in tumor tissue. The preferred linking units guarantee sufficient serum stability of the conjugate of cytostatic and carbohydrate moeity and, at the same time, the desired intracellular action within tumor cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.

  本发明涉及细胞毒素，其通过与特定的碳水化合物结合单元连接，由于这些连接单元可被金属基质蛋白酶（MMPs）、弹性蛋白酶或半胱氨酸蛋白酶等酶类选择性地裂解，因此具有肿瘤特异性作用。所述优选的连接单元保证了细胞毒素与碳水化合物结合物的足够血清稳定性，并且由于其特定的酶促或水解性裂解而在肿瘤细胞内发挥所需的细胞内作用，从而释放细胞毒素。这些酶类尤其存在于肿瘤组织中。
• Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
  申请人：Bayer Aktiengesellschaft

  公开号：EP1219634A1

  公开（公告）日：2002-07-03

  The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to specific carbohydrate moeities via preferred linking units which can be selevtively cleaved by enzymes such as metallo matrixproteases (MMPs), elastase or cathepsines, i.e. by enzymes which can especially be found in tumor tissue. The preferred linking units guarantee sufficient serum stability of the conjugate of cytostatic and carbohydrate moeity and, at the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.

  本发明涉及一种细胞抑制剂，它通过优选的连接单元与特定的碳水化合物连接，从而具有肿瘤特异性作用，这种连接单元可被金属基蛋白酶（MMPs）、弹性蛋白酶或蛋白酶等酶，即特别是在肿瘤组织中发现的酶有效地裂解。优选的连接单元可保证细胞抑制剂和碳水化合物共轭物在血清中具有足够的稳定性，同时，由于其特定的酶或水解裂解性，可释放出细胞抑制剂，从而在肿瘤细胞内发挥理想的细胞内作用。
• Abderhalden; Reich, Fermentforschung, 1930, vol. 12, p. 28
  作者：Abderhalden、Reich

  DOI：——

  日期：——
• Telomere Shortening With Aging in Human Liver
  作者：K. Takubo、K.-I. Nakamura、N. Izumiyama、E. Furugori、M. Sawabe、T. Arai、Y. Esaki、K.-I. Mafune、M. Kammori、M. Fujiwara、M. Kato、M. Oshimura、K. Sasajima

  DOI：10.1093/gerona/55.11.b533

  日期：2000.11.1

  Progressive telomere shortening with aging was studied in the normal liver tissue of 94 human subjects aged between 0 and 101 years old to determine the rate of telomere loss in 1 year. Telomere length demonstrated age-related shortening with reduction of 55 base pairs (bp) per year. The mean telomere length in five neonates was 12.9 +/- 2.6 kilobase pairs (kbp), and that in one centenarian was 8.3 kbp, Mean telomere lengths by age group were 13.2 +/- 2.0 kbp (less than or equal to8 years; 10 subjects), 7.8 +/- 1.9 kbp (40-79 years; 29 subjects), and 7.5 +/- 2.0 kbp (greater than or equal to 80 years; 53 subjects), with reduction thus appearing to show slowing on the attainment of middle age. The difference of mean telomere lengths for two groups with or without advanced malignancies of other than liver origin was not significant in the older two groups. Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 gear was almost the same as that of digestive tract mucosa, with its very rapid renewal.
• Fischer,E., Chemische Berichte, 1905, vol. 38, p. 2915
  作者：Fischer,E.

  DOI：——

  日期：——