3-isobutyl-piperazine-2,5-dione | 157240-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-isobutyl-piperazine-2,5-dione
• 英文别名: 3-(2-methylpropyl)-2,5-piperazinedione；3-(2-methylpropyl)-2,5-diketopiperazine；cyclo-(Gly-Leu)；3-Isobutyl-piperazin-dion-(2,5)；3-Isobutyl-2,5-piperazindion；(+/-)-3-Isobutyl-piperazin-2,5-dion；3-(2-methylpropyl)piperazine-2,5-dione
• CAS: 157240-56-7
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: VQFHWKRNHGHZTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,6-二异丁基六氢吡嗪-2,5-二酮 、 3-isobutyl-piperazine-2,5-dione 在 alkaline hypobromite 作用下， 生成 异戊酸
  参考文献：
  名称：

  Goldschmidt et al., Justus Liebigs Annalen der Chemie, 1927, vol. 456, p. 16

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-亮氨酰甘氨酸 生成 3-isobutyl-piperazine-2,5-dione
  参考文献：
  名称：

  Fischer,E.; Brunner, Justus Liebigs Annalen der Chemie, 1905, vol. 340, p. 147

  摘要：

  DOI：

文献信息

• The Gas-Solid-Phase 2,5-Dioxopiperazine Synthesis. Cyclization of Vaporous Dipeptides on Silica Surface
  作者：Vladimir A. Basiuk、Taras Yu. Gromovoy

  DOI：10.1135/cccc19940461

  日期：——

  The "gas solid-phase" method is used for the preparation of both symmetric and asymmetric 2,5-dioxopiperazines via cyclization of vaporous linear dipeptides in the presence of silica.

  “气固相”方法用于在硅胶存在的情况下通过蒸发线性二肽的环化制备对称和非对称的2,5-二氧吡咯烷。
• Synthesis of a “memory tripeptide” (Arg—Glu—Arg, RER) and the Kabachnik—Fields reaction with di- and tripeptides as a method for the synthesis of phosphorus-containing peptide analogs
  作者：E. D. Matveeva、T. A. Podrugina、M. V. Prisyazhnoi、S. O. Bachurin、N. S. Zefirov

  DOI：10.1007/s11172-010-0063-x

  日期：2010.1

  Methods for the synthesis of potential “twin-drugs” containing fragments of the glutamate receptor antagonist and cognitive function enhancing oligopeptides were developed. The “memory tripeptide” Arg—Glu—Arg (RER) containing the tripeptide sequence of a protein APP328–330, a gB-amyloid precursor, was synthesized. A method for the synthesis of gA-aminophosphonates with oligopeptides as the amine component of the one-pot three-component Kabachnik—Fields reaction was developed. A method for the synthesis of phosphonopeptides by the introduction of gA-aminophosphonates into the peptide chain was proposed.

  开发了包含谷氨酸受体拮抗剂片段和认知功能增强寡肽的潜在“双药”的合成方法。合成了“记忆三肽”Arg-Glu-Arg (RER)，其中含有 gB-淀粉样蛋白前体蛋白 APP328-330 的三肽序列。建立了一种以寡肽为胺组分的一锅三组分Kabachnik-Fields反应合成gA-氨基膦酸酯的方法。提出了一种通过将gA-氨基膦酸酯引入肽链来合成膦肽的方法。
• AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Republic of Korea (Management: Rural Development Administration)

  公开号：EP2594134A2

  公开（公告）日：2013-05-22

  Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.

  本文公开了一种农用制剂，其活性成分含有能够控制植物病害和促进植物生长的 2,5-二酮哌嗪衍生物或其农业上可接受的盐。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Solution casting method and polymer film
  申请人：Sugiura Masaru

  公开号：US20050077648A1

  公开（公告）日：2005-04-14

  A solvent in which dichloromethane is mixed with alcohol as a poor solvent is used for preparing a dope. Alcohol is supplied to the dope in a inline pipe to mix with a static mixer, such as a casting dope in which a composition of alcohol is increased. The temperature of the rotary drum is adjusted to −7° C. The casting dope is fed from a casting die to the rotary drum so as to form a casting film whose thickness is 40 μm. Since the content of alcohol is high and a storage modulus of the cooled casting film is at least 150 thousands Pa, the peeling defect does not occur, and the stretch is reduced as far as possible. A gel-like film is dried by a tenter type drying device, and stretched such that the stretch ratio is at most 110%. The produced film is thin and excellent in a surface condition and optical isotropy.

  二氯甲烷与作为劣质溶剂的酒精混合的溶剂用于制备涂料。酒精通过内联管道供应到涂料中，与静态混合器混合，如增加酒精成分的铸造涂料。将浇注料从浇注模具送入旋转滚筒，以形成厚度为 40 μm 的浇注膜。由于酒精含量高，冷却后的浇注膜的储存模量至少为 15 万帕，因此不会出现剥离缺陷，拉伸也尽可能减小。凝胶状薄膜由拉幅机干燥，拉伸率不超过 110%。生产出的薄膜很薄，表面状态和光学各向同性都很好。