furan-2-carboxylic acid tert-pentylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: furan-2-carboxylic acid tert-pentylamide
• 英文别名: Furan-2-carbonsaeure-tert-pentylamid；N-(2-methylbutan-2-yl)furan-2-carboxamide
• 化学式: C₁₀H₁₅NO₂
• mdl: MFCD05661003
• 分子量: 181.235
• InChiKey: PGVGOZGQAMEPDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  呋喃甲酰氯 、 叔戊基胺 在 氢氧化钾 作用下， 生成 furan-2-carboxylic acid tert-pentylamide
  参考文献：
  名称：

  Some N-Alkyl N'-Aryl Furamidines

  摘要：

  DOI：

  10.1021/ja01865a017

文献信息

• YEATS INHIBITORS AND METHODS OF USE THEREOF
  申请人：The University of Hong Kong

  公开号：US20210277061A1

  公开（公告）日：2021-09-09

  Disclosed herein are compositions and methods suitable for treating acute leukemia by inhibiting π π π stacking in the YEATS protein domain. YEATS protein domains are typically found in a variety of chromatin modification molecular complexes. Cancer cells are characterized by aberrant epigenetic landscapes and often exploit chromatin machinery to activate oncogenic gene expression programs. Quantitative analysis of the inhibitory activity of YEATS domain inhibitors by use of a fluorescence-based assay revealed that several of the tested inhibitors achieved 50% inhibition at the submicro/nanomolar level. As such, provided is the use of small molecule inhibitors that target the ENL YEATS domain to selectively kill leukemic MLL-r cells.
• Some N-Alkyl N'-Aryl Furamidines
  作者：William M. Degnan、Frank B. Pope

  DOI：10.1021/ja01865a017

  日期：1940.8