1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate | 913622-40-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate
• 英文别名: 1-(3-Formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 2,4-dihydroxy-5-iodobenzoate
• CAS: 913622-40-9
• 化学式: C₁₈H₁₈INO₈
• 分子量: 503.247
• InChiKey: VYOZOBJIWIISHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate 在 palladium diacetate 作用下， 以 乙酸乙酯 为溶剂， 反应 0.5h， 以71%的产率得到1-(5-formamido-2-methoxy-3,6-dioxocyclohexa-1,4-dienyl)propan-2-yl 2,4-dihydroxy-5-iodobenzoate
  参考文献：
  名称：

  Design, Synthesis, and StructureActivity Relationships for Chimeric Inhibitors of Hsp90

  摘要：

  Inhibition of the 90 kDa heat shock protein (Hsp90) family of molecular chaperones represents a promising new chemotherapeutic approach toward the treatment of several cancers. Previous studies have demonstrated that the natural products, radicicol and geldanamycin, are potent inhibitors of the Hsp90 N-terminal ATP binding site. The cocrystal structures of these molecules bound to Hsp90 have been determined, and through molecular modeling and superimposition of these ligands, hybrids of radicicol and geldanamycin have been designed. A series of macrocylic chimeras of radicicol and geldanamycin and the corresponding seco-agents have been prepared and evaluated for both antiproliferative activity and their ability to induce Hsp90-dependent client protein degradation.

  DOI：

  10.1021/jo061054f
• 作为产物：
  描述：

  1-(2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenyl)propan-2-ol 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 三甲基氯硅烷 、 N,N'-二环己基碳二亚胺 、 sodium iodide 、 tin(ll) chloride 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 24.58h， 生成 1-(3-formamido-2,5-dihydroxy-6-methoxyphenyl)propan-2-yl 5-iodo-2,4-dihydroxybenzoate
  参考文献：
  名称：

  Design, Synthesis, and StructureActivity Relationships for Chimeric Inhibitors of Hsp90

  摘要：

  Inhibition of the 90 kDa heat shock protein (Hsp90) family of molecular chaperones represents a promising new chemotherapeutic approach toward the treatment of several cancers. Previous studies have demonstrated that the natural products, radicicol and geldanamycin, are potent inhibitors of the Hsp90 N-terminal ATP binding site. The cocrystal structures of these molecules bound to Hsp90 have been determined, and through molecular modeling and superimposition of these ligands, hybrids of radicicol and geldanamycin have been designed. A series of macrocylic chimeras of radicicol and geldanamycin and the corresponding seco-agents have been prepared and evaluated for both antiproliferative activity and their ability to induce Hsp90-dependent client protein degradation.

  DOI：

  10.1021/jo061054f