2'-甲酰基-[1,1'-联苯基]-2-基二乙基氨基甲酸酯 | 209863-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2'-甲酰基-[1,1'-联苯基]-2-基二乙基氨基甲酸酯
• 英文名称: Diethyl-carbamic acid 2'-formyl-biphenyl-2-yl ester
• 英文别名: [2-(2-formylphenyl)phenyl] N,N-diethylcarbamate
• CAS: 209863-07-0
• 化学式: C₁₈H₁₉NO₃
• 分子量: 297.354
• InChiKey: SBEFMISHLUWOOR-UHFFFAOYSA-N

物化性质

• 沸点：
  456.0±45.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2'-甲酰基-[1,1'-联苯基]-2-基二乙基氨基甲酸酯 在 lithium aluminium tetrahydride 、 Jones’ reagent 作用下， 以 丙酮 为溶剂， 生成 苯并[c]苯并吡喃-6-酮
  参考文献：
  名称：

  The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes

  摘要：

  The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin - Leznoff acetal - linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00779-5
• 作为产物：
  描述：

  2,N,N,-diethylcarbamyloxyphenyl boronic acid 、 [2-(2-Bromo-phenyl)-[1,3]dioxolan-4-yl]-methanol 在 四(三苯基膦)钯 盐酸 、 sodium 、 sodium carbonate 、 Merrifield resin 作用下， 生成 2'-甲酰基-[1,1'-联苯基]-2-基二乙基氨基甲酸酯
  参考文献：
  名称：

  The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes

  摘要：

  The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin - Leznoff acetal - linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00779-5

文献信息

• The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes
  作者：S. Chamoin、S. Houldsworth、C.G. Kruse、W. Iwema Bakker、V. Snieckus

  DOI：10.1016/s0040-4039(98)00779-5

  日期：1998.6

  The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin - Leznoff acetal - linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated. (C) 1998 Elsevier Science Ltd. All rights reserved.