甲基N-(环丙基甲基)甘氨酸酯 | 6201-01-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基N-(环丙基甲基)甘氨酸酯
• 英文名称: ethyl 2-((cyclopropylmethyl)amino)acetate
• 英文别名: ethyl N-cyclopropylmethylglycinate；Ethyl 2-[(cyclopropylmethyl)amino]acetate；ethyl 2-(cyclopropylmethylamino)acetate
• CAS: 6201-01-0
• 化学式: C₈H₁₅NO₂
• mdl: MFCD11150512
• 分子量: 157.213
• InChiKey: BFFAICONXNLADT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole 、 甲基N-(环丙基甲基)甘氨酸酯 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以81%的产率得到Ethyl 2-[cyclopropylmethyl-[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]amino]acetate
  参考文献：
  名称：

  [EN] SGC STIMULATORS
  [FR] STIMULATEURS DE SGC

  摘要：

  公开号：

  WO2014144100A3
• 作为产物：
  描述：

  环丙基甲基4-甲基苯磺酸酯 、 甘氨酸乙酯盐酸盐 在 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 18.0h， 生成 甲基N-(环丙基甲基)甘氨酸酯
  参考文献：
  名称：

  Peptide deformylase inhibitors with retro-amide scaffold: Synthesis and structure–activity relationships

  摘要：

  Peptide deformylase (PDF) is a metalloprotease catalyzing the removal of a formyl group from newly synthesized proteins. Thus inhibition of PDF activity is considered to be one of the most effective antibiotic strategies. Reported herein are the synthesis and structure-activity relationship studies of retro-amide inhibitors based on actinonin, a naturally occurring PDF inhibitor. Analysis of the structure-activity relationships led to the discovery of 7a, which exhibits potent enzyme inhibition and antibacterial activity against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.088

文献信息

• Fused heterocyclic compounds
  申请人：——

  公开号：US20040082607A1

  公开（公告）日：2004-04-29

  The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; R 1 and R 2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like. 1

  本发明提供了一种化合物，其化学式如下：其中环A是一个可选择取代的5至10成员芳香环；R1和R2相同或不同，每个都是一个可选择取代的碳氢化合物基团或可选择取代的杂环基团；X是一个键等；L是一个二价碳氢基团，以及其盐，但不包括3-(氨甲基)-2,6,7-三甲基-4-苯基-1(2H)-异喹啉酮，3-(氨甲基)-2-甲基-4-苯基-1(2H)-异喹啉酮，3-(氨甲基)-6-氯-2-甲基-4-苯基-1(2H)-异喹啉酮和3-(氨甲基)-2-异丙基-4-苯基-1(2H)-异喹啉酮。该化合物表现出优越的肽酶抑制活性，并可用作糖尿病的预防或治疗剂等。
• Tetrahydro-pyridinyl pyrazole cannabinoid modulators
  申请人：Xia Mingde

  公开号：US20060089378A1

  公开（公告）日：2006-04-27

  This invention is directed to a tetrahydro-pyridinyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.

  这项发明涉及一种式(I)的四氢吡啶基吡唑类大麻素调节剂化合物，以及一种用于治疗、改善或预防大麻素受体介导的综合症、疾病或疾病的方法。
• Organic Compounds and Their Uses
  申请人：Cottens Sylvain

  公开号：US20070265281A1

  公开（公告）日：2007-11-15

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

  本申请描述了有机化合物，可用于治疗、预防和/或改善人类疾病。
• sGC STIMULATORS
  申请人：IRONWOOD PHARMACEUTICALS, INC.

  公开号：US20160031903A1

  公开（公告）日：2016-02-04

  Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  本文描述了化学式I'和I的化合物，它们可用作sGC的刺激剂，特别是NO独立，血红素依赖性的刺激剂。这些化合物还可用于治疗、预防或管理本文中披露的各种疾病。
• Heterocyclic fused tricyclic compounds
  申请人：ICI AMERICAS INC.

  公开号：EP0245053A1

  公开（公告）日：1987-11-11

  Compounds of the formula (wherein A represents a substituted 5- or 6-membered aryl or heteroaryl ring, Rb represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl, Rc represents hydrogen, alkyl or alkanoyl, n is 1 or 2 and X is C - H or N) and the salts thereof are useful as agents for binding to benzodiazepine receptors and possess anxiolytic activity.

  式中化合物 (其中 A 代表取代的 5 或 6 元芳基或杂芳基环，Rb 代表任选取代的烷基、烯基、炔基、环烷基、环烷基烷基、芳基、芳烷基、杂芳基或杂芳基烷基，Rc 代表氢、烷基或烷酰基，n 为 1 或 2，X 为 C - H 或 N）及其盐类可用作与苯二氮卓受体结合的制剂，并具有抗焦虑活性。