N-ethyl-N-[2-[ethyl-(2-iodobenzoyl)amino]phenyl]-2-iodobenzamide | 1263375-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N-[2-[ethyl-(2-iodobenzoyl)amino]phenyl]-2-iodobenzamide
• CAS: 1263375-92-3
• 化学式: C₂₄H₂₂I₂N₂O₂
• 分子量: 624.26
• InChiKey: CFPMNGOQZACAOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-ethyl-N-[2-[ethyl-(2-iodobenzoyl)amino]phenyl]-2-iodobenzamide 在 四丁基溴化铵 、 potassium acetate 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以94%的产率得到3,22-Diethyl-3,22-diazapentacyclo[12.8.0.02,11.05,10.015,20]docosa-1(14),2(11),5,7,9,12,15,17,19-nonaene-4,21-dione
  参考文献：
  名称：

  Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes

  摘要：

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.

  DOI：

  10.1080/00397910903531870
• 作为产物：
  描述：

  邻碘苯甲酰氯 、 1-N,2-N-二乙基苯-1,2-二胺 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以82%的产率得到N-ethyl-N-[2-[ethyl-(2-iodobenzoyl)amino]phenyl]-2-iodobenzamide
  参考文献：
  名称：

  Palladium-Mediated Bis-Arylation of Inactivated and Activated Arenes

  摘要：

  A simple synthetic protocol has been developed for the bis-arylation of unactivated and activated arenes by the implementation of a palladium-catalyzed intramolecular cyclization strategy. The activated arenes give either linearly fused or angularly fused bis-cyclized product depending upon the substitutent present on the nitrogen atom, whereas inactivated arenes give only linearly fused product. The reaction has been carried out in two steps under ligand-free conditions.

  DOI：

  10.1080/00397910903531870