4-(4-methoxybenzylideneamino)benzyl alcohol | 41371-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-methoxybenzylideneamino)benzyl alcohol
• 英文别名: 4-[[(4-Methoxyphenyl)methylene]amino]benzenemethanol；[4-[(4-methoxyphenyl)methylideneamino]phenyl]methanol
• CAS: 41371-38-4
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: OTDLMZMQIZUEBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.94
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  41.82
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(4-methoxybenzylideneamino)benzyl alcohol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2-((4-methoxyphenyl)-4-oxo-3-phenoxyazetidin-1-yl)benzyl acrylate
  参考文献：
  名称：

  Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers

  摘要：

  This report describes the preparation of some new beta-lactam nanocopolymers. These nanoparticles are synthesized in water by emulsion polymerization of an acrylate beta-lactam pre-dissolved in a mixture of co-monomers in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 30-70 nm in diameter. These compounds have been evaluated for their antimalarial activities against chloroquine-resistant Plasmodium faliparum K1 strain demonstrating IC50 varying from 14 to 50 A mu M. The interactions between these beta-lactam nanocopolymers and the P. falciparum single-stranded DNA-binding proteins have been studied by molecular docking calculations.

  DOI：

  10.1007/s00044-015-1477-7
• 作为产物：
  描述：

  对氨基苯甲醇 、 4-甲氧基苯甲醛 在 溶剂黄146 作用下， 以 苯 为溶剂， 反应 17.0h， 以81%的产率得到4-(4-methoxybenzylideneamino)benzyl alcohol
  参考文献：
  名称：

  Schiff bases derived from p-aminobenzyl alcohol as trigger groups for pH-dependent prodrug activation

  摘要：

  A number of novel acid-sensitive Schiff bases derived horn p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions The kinetics of acid-catalyzed hydiolysis at pH 50 as well as stability at pH 74 were studied using fluorogenic model compounds Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5 0 combined with a long-term stability at pH 74 and are considered suitable candidates for the development of anticancer prodrugs (c) 2010 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2010.06.055