tert-butyl (1S)-(1-{[(propane-2-sulfonyl)amino]carbonyl}butyl)carbamate | 875105-69-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (1S)-(1-{[(propane-2-sulfonyl)amino]carbonyl}butyl)carbamate
• CAS: 875105-69-4
• 化学式: C₁₃H₂₆N₂O₅S
• 分子量: 322.426
• InChiKey: WZQLLPNDNYESMO-JTQLQIEISA-N

物化性质

• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  101.57
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (1S)-(1-{[(propane-2-sulfonyl)amino]carbonyl}butyl)carbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以100%的产率得到N-[(2S)-2-aminopentanoyl]propane-2-sulfonamide hydrochloride
  参考文献：
  名称：

  Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

  摘要：

  The hepatitis C virus (HCV) NS3 protease has emerged as a promising anti-HCV drug target. Herein, we present an investigation of NS3 inhibitors comprising the acyl sulfonamide functionality. A series of tetra- and tripeptide based acyl sulfonamide inhibitors and their structure-activity relationships from both enzymatic and cell-based in vitro assays are presented. In summary, the acidity of the acyl sulfonamide functionality, the character of the P1 side chain, and the acyl sulfonamide substituent were found to be important for the inhibitory potencies. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.08.045
• 作为产物：
  描述：

  N-tert-butoxycarbonyl-L-norvaline 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 tert-butyl (1S)-(1-{[(propane-2-sulfonyl)amino]carbonyl}butyl)carbamate
  参考文献：
  名称：

  Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

  摘要：

  The hepatitis C virus (HCV) NS3 protease has emerged as a promising anti-HCV drug target. Herein, we present an investigation of NS3 inhibitors comprising the acyl sulfonamide functionality. A series of tetra- and tripeptide based acyl sulfonamide inhibitors and their structure-activity relationships from both enzymatic and cell-based in vitro assays are presented. In summary, the acidity of the acyl sulfonamide functionality, the character of the P1 side chain, and the acyl sulfonamide substituent were found to be important for the inhibitory potencies. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.08.045