4-(2-acetoxy-ethoxy)-3-methylbenzaldehyde | 854107-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-acetoxy-ethoxy)-3-methylbenzaldehyde
• 英文别名: 4-(2-Acetoxy-ethoxy)-3-methylbenzaldehyde；2-(4-formyl-2-methylphenoxy)ethyl acetate
• CAS: 854107-59-8
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: JWGPLBHJHABGOW-UHFFFAOYSA-N

物化性质

• 沸点：
  334.9±27.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴乙基乙酸酯 、 3-甲基-4-羟基苯甲醛 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 18.0h， 生成 4-(2-acetoxy-ethoxy)-3-methylbenzaldehyde
  参考文献：
  名称：

  [EN] 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS
  [FR] DERIVES DE 5-(BENZ-(Z)-YLIDENE)-THIAZOLIDINE-4-ONE UTILISES COMME AGENT IMMUNODEPRESSEURS

  摘要：

  这项发明涉及含有至少一种5-(苯基(Z)-基噻唑烷酮衍生物(I)的药物组合物，用于预防或治疗与激活的免疫系统相关的疾病。此外，该发明涉及新型噻唑烷酮衍生物，特别用作药用活性化合物。这些化合物特别还作为免疫抑制剂起作用。

  公开号：

  WO2005054215A1

文献信息

• Novel thiazolidin-4-one derivatives
  申请人：Binkert Christoph

  公开号：US20070082933A1

  公开（公告）日：2007-04-12

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及包含至少一种噻唑烷-4-酮衍生物的药物组合物，用于预防或治疗与激活的免疫系统相关的疾病。此外，本发明涉及新型噻唑烷-4-酮衍生物，特别用作药物活性化合物。这些化合物还特别作为免疫抑制剂发挥作用。
• NOVEL THIAZOLIDIN 4-ONE DERIVATIVES
  申请人：Binkert Christoph

  公开号：US20090275625A1

  公开（公告）日：2009-11-05

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的制药组合物，用于预防或治疗与激活免疫系统相关的疾病。此外，本发明还涉及新的噻唑烷-4-酮衍生物，特别用作药物活性化合物。该化合物还特别作为免疫抑制剂发挥作用。
• NOVEL THIAZOLIDIN-4-ONE DERIVATIVES
  申请人：Binkert Christoph

  公开号：US20080280962A1

  公开（公告）日：2008-11-13

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的制药组合物，用于预防或治疗与激活免疫系统相关的疾病。此外，本发明还涉及新颖的噻唑烷-4-酮衍生物，特别用于作为药物活性化合物。这些化合物还特别作为免疫抑制剂。
• Thiazolidin 4-one derivatives
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US08273779B2

  公开（公告）日：2012-09-25

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  该发明涉及含有至少一种噻唑啉-4-酮衍生物的药物组合物，用于预防或治疗与激活的免疫系统相关的疾病。此外，该发明涉及新的噻唑啉-4-酮衍生物，特别用于作为药物活性化合物。所述化合物也特别作为免疫抑制剂。
• Thiazolidin-4-one derivatives
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US07875726B2

  公开（公告）日：2011-01-25

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及药物组合物，其含有至少一种噻唑啉-4-酮衍生物，用于预防或治疗与激活免疫系统相关的疾病。此外，本发明还涉及新型噻唑啉-4-酮衍生物，特别适用于作为药物活性化合物。这些化合物也特别作为免疫抑制剂。