石耳酸 | 548-89-0

• 物质功能分类: 生物化工 - 中草药成分
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 石耳酸
• 英文名称: gyrophoric acid
• 英文别名: Gyrophorsaeure；4-[4-(2,4-dihydroxy-6-methyl-benzoyloxy)-2-hydroxy-6-methyl-benzoyloxy]-2-hydroxy-6-methyl-benzoic acid；4-[4-(2,4-Dihydroxy-6-methyl-benzoyloxy)-2-hydroxy-6-methyl-benzoyloxy]-2-hydroxy-6-methyl-benzoesaeure；6-Oxy-4-(4.6-dioxy-2-methyl-benzoyloxy)-2-methyl-benzoesaeure-(5-oxy-3-methyl-4-carboxy-phenylester)；p-Triorsellinsaeure；6-Hydroxy-4-<6-hydroxy-4-(4.6-dihydroxy-2-methyl-benzoyloxy)-2-methyl-benzoyloxy>-2-methyl-benzoesaeure; Gyrophorsaeure；4-[4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoyl]oxy-2-hydroxy-6-methylbenzoic acid
• CAS: 548-89-0
• 化学式: C₂₄H₂₀O₁₀
• 分子量: 468.417
• InChiKey: ATQPZSQVWCPVGV-UHFFFAOYSA-N

物化性质

• LogP：
  6.620 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  171
• 氢给体数：
  5
• 氢受体数：
  10

制备方法与用途

性质

石耳酸（Gyrophoric acid）易溶于丙酮、氯仿、甲醇和乙醇。其醇溶液与三氯化铁作用呈葡萄酒色，与氢氧化钾作用呈黄色。它是石耳中的有效成分。

用途

石耳酸是从脐衣科植物石耳的子实体中提取的有效成分。石耳具有养阴、止血的功效，可用于治疗劳咳吐血、肠风下血、痔漏及脱肛等症状。

反应信息

• 作为反应物：
  描述：

  石耳酸 在 溶剂黄146 作用下， 生成 2,4-二羟基-6-甲基苯甲酸
  参考文献：
  名称：

  Hesse, Journal fur praktische Chemie (Leipzig 1954), 1900, vol. <2> 62, p. 442

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 丙酮 作用下， 生成 石耳酸
  参考文献：
  名称：

  Asahina; Yosioka, Chemische Berichte, 1937, vol. 70, p. 200,204

  摘要：

  DOI：

文献信息

• LIPO-AMINO ACID ALKYL ESTERS AS SPF BOOSTERS
  申请人：Prodotti Gianni S.r.l.

  公开号：EP4011357A1

  公开（公告）日：2022-06-15

  The use of lipo-amino acid alkyl esters as SPF (Sun Protection Factor) boosters in cosmetic compositions comprising a sun filter is described. Said alkyl esters, when added to cosmetic compositions containing a sun filter, increase their SPF value to an extent of even 50% or higher: it is thereby possible to significantly reduce the amount of sun filter used, while maintaining a high SPF. The SPF booster effect was observed in different types of cosmetic compositions and with different sun filters, thereby supporting the wide use of the present alkyl esters in cosmetic compositions for the use described herein. Said alkyl esters have a strong natural connotation, respectful of the environment and of the organic tissues, and can in turn be obtained by eco-friendly synthesis methods which do not involve the use of aggressive reagents which could remain in traces in the final cosmetic product: photoprotective cosmetic compositions are thereby obtained which have high safety of use and are likely to be better accepted by the consumer.

  本文介绍了在含有防晒剂的化妆品组合物中使用脂氨基酸烷基酯作为 SPF（防晒系数）增强剂的情况。将上述烷基酯添加到含有防晒剂的化妆品组合物中，可以将其 SPF 值提高到 50%或更高：这样就可以在保持较高 SPF 值的同时显著减少防晒剂的用量。在不同类型的化妆品组合物和不同的防晒滤光剂中都观察到了 SPF 增效作用，从而支持了本发明的烷基酯在化妆品组合物中的广泛应用。所述烷基酯具有强烈的天然内涵，尊重环境和有机组织，可以通过环保的合成方法获得，不需要使用可能在最终化妆品中残留痕量的侵蚀性试剂：因此获得的防晒化妆品组合物具有很高的使用安全性，可能更容易被消费者接受。
• Polyhipes by interfacial step-growth polymerization
  申请人：Technion Research & Development Foundation Limited

  公开号：US10851218B2

  公开（公告）日：2020-12-01

  A polyHIPE-templated composition-of-matter afforded by interfacial polymerization, comprising a polymer of alternating residues of hydrophobic and hydrophilic monomers. The described composition-of-matter is characterized by an open-, quasi-closed- or a truly closed-cell microstructure, whereas the latter is capable of non-releasably or releasably encapsulating an organic or aqueous composition therein for extended periods of time, as well as various uses thereof.

  一种通过界面聚合法获得的聚 HIPE 模板物质组合物，由疏水单体和亲水单体交替残留的聚合物组成。所述物质组合物的特点是具有开孔、准闭孔或真正闭孔的微观结构，而后者能够以不可释放或可释放的方式将有机或水性组合物长时间封装在其中，并具有多种用途。
• Experimental study of the generation of periodic internal waves by the boundary layer on a rotating disk
  作者：Yu. D. Chashechkin、Yu. V. Kistovich、Yu. S. Il'inykh

  DOI：10.1134/1.1333872

  日期：2000.11
• Huneck, Siegfried; Schmidt, Juergen; Tabacchi, Raffaele, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1989, vol. 44, # 10, p. 1283 - 1289
  作者：Huneck, Siegfried、Schmidt, Juergen、Tabacchi, Raffaele

  DOI：——

  日期：——
• Sustaining potato crop, land and industry health beyond the year 2000: Current issues and future needs
  作者：H. W. (Bud) Platt、E. S. Plissey、G. R. MacKay、M. Adams、M. K. Hinkle、E. MacDonald

  DOI：10.1007/bf02853955

  日期：2000.9