石绿 | 12002-03-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 石绿
• 中文别名: 祖母绿；巴黎绿；乙酰亚砷酸铜
• 英文名称: Copper acetoarsenite
• 英文别名: tetracopper;oxoarsinite;diacetate
• CAS: 12002-03-8
• 化学式: C4H6As6Cu4O16
• 分子量: 1013.79
• InChiKey: HTSABAUNNZLCMN-UHFFFAOYSA-F

计算性质

• 辛醇/水分配系数(LogP)：
  -12.63
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  321
• 氢给体数：
  0
• 氢受体数：
  16

ADMET

代谢

在狗的红细胞中迅速出现无机砷的代谢物亚砷酸二甲酯，然后出现在血浆中。在6小时内，大部分剩余的砷是亚砷酸二甲酯。无机砷和亚砷酸二甲酯都会迅速通过尿液排出。

FOLLOWING IV INORG ARSENIC, METABOLITE DIMETHYLARSINIC ACID APPEARED RAPIDLY /DOG/ IN ERYTHROCYTES, THEN PLASMA. WITHIN 6 HR MOST ARSENIC REMAINING WAS DIMETHYLARSENIC ACID. BOTH INORG ARSENIC & DIMETHYLARSENIC ACID RAPIDLY EXCRETED IN URINE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

致癌性分类：1）人类证据：充分；2）动物证据：有限。对人类致癌风险的整体总结评估为第1组：对人类致癌。注意：此评估适用于整个化学物质组，而不一定适用于组内所有单个化学物质。/砷和砷化合物/

Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. /Arsenic and arsenic compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：A；人类致癌物。分类依据：基于足够的人类数据证据。在主要通过吸入暴露的多个人类群体中观察到了肺癌死亡率的增加。此外，在饮用含有高无机砷的饮用水的人群中，观察到了多种内脏器官癌症（肝脏、肾脏、肺和膀胱）死亡率的增加以及皮肤癌发病率的增加。人类致癌性数据：充足。动物致癌性数据：不足。/无机砷/

CLASSIFICATION: A; human carcinogen. BASIS FOR CLASSIFICATION: Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic. HUMAN CARCINOGENICITY DATA: Sufficient. ANIMAL CARCINOGENICITY DATA: Inadequate. /Inorganic Arsenic/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A1：确认的人类致癌物。/砷和无机化合物，如As/

A1: Confirmed human carcinogen. /Arsenic and inorganic cmpd, as As/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 感觉运动 职业性肝毒素 - 次级肝毒素：职业环境中潜在的有毒效应基于人类摄入或动物实验的中毒案例。 再生障碍性贫血 - 血液中增多的变性血红蛋白；该化合物被归类为原发性有毒效应。 生殖毒素 - 对生殖系统有毒的化学物质，包括对后代缺陷以及对男性或女性生殖功能的损害。生殖毒性包括发育效应。参见生殖毒性风险评估指南。 国际癌症研究机构(IARC)致癌物 - 1类：国际癌症研究机构将化学物质分类为确定的人类致癌物。 美国国家毒理学项目(NTP)致癌物 - 已知是人类致癌物。 美国职业健康安全研究所(ACGIH)致癌物 - 确认的人类致癌物。

Neurotoxin - Sensorimotor Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Aplastic anemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment. IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens. NTP Carcinogen - Known to be a human carcinogen. ACGIH Carcinogen - Confirmed Human.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

一种极具特征性的皮炎，局限于阴囊、腹股沟区域和鼻唇沟，可能在中度职业暴露于巴黎绿后发生。病变始于红斑，常发展为湿疹并伴有渗出，可能会开始愈合并形成黑色结痂。可能涉及致敏反应……在不太急性的情况下，可能出现过度角化、过度出汗或黑色素沉着。……色素沉着在暴露于光线的表面最为明显。……色素区域可能出现斑点状脱色，呈现出所谓的雨滴外观。

A highly characteristic dermatitis confined to the scrotum, inguinal area, and nasolabial folds may follow moderate occupational exposure to paris green. The lesions begin with erythema, frequently become eczematous and weeping, & may start to heal with ... black scab. A sensitization reaction may be involved ... In less acute cases, hyperkeratosis, hyperhidrosis, or melanosis may occur. ... The hyperpigmentation is most marked on surfaces exposed to light. ... There may be a speckled depigmentation of pigmented areas giving the so called raindrop appearance.

来源:Hazardous Substances Data Bank (HSDB)