6-(溴甲基)苯并[b]芘 | 49852-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 6-(溴甲基)苯并[b]芘
• 英文名称: 6-Brommethylbenzpyren
• 英文别名: 6-Brommethylbenz[a]pyren；6-Bromomethylbenzo(a)pyrene；6-(bromomethyl)benzo[a]pyrene
• CAS: 49852-85-9
• 化学式: C₂₁H₁₃Br
• 分子量: 345.238
• InChiKey: DMAOOKLAQXNHTK-UHFFFAOYSA-N

物化性质

• 沸点：
  401.54°C (rough estimate)
• 密度：
  1.3677 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

SDS

制备方法与用途

类别：有毒物质

可燃性危险特性： 热分解时会排出有毒溴化物烟雾。

储运特性： 应存放在通风良好、低温干燥的库房中。

灭火剂： 可用水、干粉、干砂、二氧化碳、泡沫或1211灭火剂进行灭火。

反应信息

• 作为产物：
  描述：

  苯并[a]芘 在 sodium tetrahydroborate 、 三溴化磷 、 三氯氧磷 作用下， 以 乙醇 、 苯 为溶剂， 生成 6-(溴甲基)苯并[b]芘
  参考文献：
  名称：

  与6-羟甲基苯并（a）py有关的化合物的合成和致癌性。

  摘要：

  DOI：

  10.1021/jm00264a034

文献信息

• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• [EN] MULTI-STAGE STEM CELL CARCINOGENESIS<br/>[FR] CARCINOGENESE DE CELLULES SOUCHES MULTIETAPES
  申请人：STEMLIFELINE INC

  公开号：WO2010037134A2

  公开（公告）日：2010-04-01

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• Synthesis and carcinogenicity of compounds related to 6-hydroxymethylbenzo[a]pyrene
  作者：R. K. Natarajan、J. W. Flesher

  DOI：10.1021/jm00264a034

  日期：1973.6