1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione | 21035-81-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione
• 英文别名: 3,4-(1',3'-Dibenzyl-2'-oximidazolido)-5-hydroxy-2-oxo-tetrahydrofuran；(3aSR,6aRS)1,3-Dibenzyl-6-hydroxy-tetrahydro-4H-furo[3,4-d]imidazol-2,4(1H)-dion；1,3-dibenzyl-6-hydroxy-6,6a-dihydro-3aH-furo[3,4-d]imidazole-2,4-dione
• CAS: 21035-81-4
• 化学式: C₁₉H₁₈N₂O₄
• 分子量: 338.363
• InChiKey: PNBTVNTZIRFTBL-UHFFFAOYSA-N

物化性质

• 沸点：
  627.5±55.0 °C(Predicted)
• 密度：
  1.394±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione 生成 (+/-)-1,3-dibenzyl-5c-formyl-2-oxo-imidazolidine-4r-carboxylic acid
  参考文献：
  名称：

  SENUMA, MASARU;FUJII, TAKEHIKO;SETO, MASAHIKO;OKAMURA, KIMIO;DATE, TADAMA+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 882-887

  摘要：

  DOI：
• 作为产物：
  描述：

  (3aS,6aR)-1,3-Dibenzyl-6-acetoxy-tetrahydro-4H-furo<3,4-d>imidazol-2,4(1H)-dion 生成 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione
  参考文献：
  名称：

  SENUMA, MASARU;FUJII, TAKEHIKO;SETO, MASAHIKO;OKAMURA, KIMIO;DATE, TADAMA+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 882-887

  摘要：

  DOI：

文献信息

• Desymmetric hydrogenation of a meso-cyclic acid anhydride toward biotin synthesis
  作者：Masahiro Yoshimura、Kazuomi Tsuda、Hiroshi Nakatsuka、Tomoya Yamamura、Masato Kitamura

  DOI：10.1016/j.tet.2011.09.065

  日期：2011.12

  Catalytic reactivity in the hydrogenation of a cyclic anhydride to a biotin synthetic intermediate has been investigated on the basis of Lyons' original method using Wilkinson Ru complex, revealing the high performance of DPPF and XANTPHOS diphosphines possessing wide bite angles. The results have shown a new trail for design of the corresponding asymmetric catalysts, and the potential utility of (S,S)-Et-FerroTANE and (S,S)-(R,R)-Ph-TRAP has been demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.
• SENUMA, MASARU;FUJII, TAKEHIKO;SETO, MASAHIKO;OKAMURA, KIMIO;DATE, TADAMA+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 882-887
  作者：SENUMA, MASARU、FUJII, TAKEHIKO、SETO, MASAHIKO、OKAMURA, KIMIO、DATE, TADAMA+

  DOI：——

  日期：——
• US7803952B2
  申请人：——

  公开号：US7803952B2

  公开（公告）日：2010-09-28