1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one | 170642-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one
• 英文别名: 1-Hydroxy-2,2,5,5-tetramethylpyrrolidin-3-one
• CAS: 170642-05-4
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: MQZTWGVNWAVVQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one 在 manganese(IV) oxide 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-one
  参考文献：
  名称：

  Reaction of 2-substituted 5,5-dimethyl-4-oxo-1-pyrroline-1-oxides with nucleophilic reagents and synthesis of nitroxyl radicals?derivatives of pyrrolidine

  摘要：

  DOI：

  10.1007/bf00960663
• 作为产物：
  描述：

  甲基碘化镁 、 2,2,5-Trimethyl-1-oxy-2,4-dihydro-pyrrol-3-one 以 四氢呋喃 、 乙醚 为溶剂， 反应 12.0h， 生成 1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one
  参考文献：
  名称：

  Reaction of 2-substituted 5,5-dimethyl-4-oxo-1-pyrroline-1-oxides with nucleophilic reagents and synthesis of nitroxyl radicals?derivatives of pyrrolidine

  摘要：

  DOI：

  10.1007/bf00960663

文献信息

• Drug Resistance Reversal In Neoplastic Disease
  申请人：Patil Ghanshyam

  公开号：US20080200405A1

  公开（公告）日：2008-08-21

  The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.

  本发明涉及用于阻止或逆转肿瘤性疾病化疗耐药效应的化合物、组合物和方法。具体描述了羟胺的使用。
• [DE] VERFAHREN ZUR REKTIFIKATIVEN AUFTRENNUNG VON (METH)ACRYLMONOMERE ENTHALTENDEN FLÜSSIGKEITEN IN EINER REKTIFIKATIONSKOLONNE<br/>[EN] METHOD FOR THE RECTIFYING SEPARATION OF LIQUIDS CONTAINING (METH)ACRYLIC MONOMERS IN A RECTIFICATION COLUMN<br/>[FR] PROCEDE POUR RECTIFIER PAR SEPARATION DES LIQUIDES CONTENANT DES MONOMERES (METH)ACRYLIQUES DANS UNE COLONNE DE RECTIFICATION
  申请人：BASF AG

  公开号：WO2004050596A1

  公开（公告）日：2004-06-17

  Verfahren der rektifikativen Auftrennung von (Meth)acrylmonomere enthaltenden Flüssigkeiten in einer Rektifikationskolonne, bei dem man aus der Rektifikationskolonne einen Stoffstrom entnimmt und als mit molekularem Sauerstoff angereicherte Flüssigphase in die Rektifikationskolonne rückführt.

  将含有（甲基）丙烯酸酯单体的液体进行精馏分离的方法，其中从精馏塔中取出一种物流，并将其作为富含分子氧的液相重新引入精馏塔。
• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• Method for producing higher (meth)acrylic acid esters
  申请人：——

  公开号：US20040019235A1

  公开（公告）日：2004-01-29

  Higher (meth)acrylates are prepared by reacting (meth)acrylic acid and the alcohol in the presence of at least one acidic catalyst and at least one polymerization inhibitor and in the presence of a solvent which forms an azeotropic mixture with water and distilling off and condensing the azeotropic mixture, the condensate separating into an aqueous phase and an organic phase, by a process in which a) the esterification is carried out in a reactor having a circulation evaporator and b) in the presence of at least 10% by weight, based on the reaction mixture, of solvent, and either c1) at least a part of the solvent, if required a part of the catalyst (mixture) and, if required, at least a part of the polymerization inhibitor (mixture) are initially taken in the esterification reactor and heated to the boiling point of the component having the lowest boiling point in the system and, as soon as the circulation is in operation, (meth)acrylic acid and alcohol and, if required, residual catalyst, polymerization inhibitor and solvent are metered in together or separately, or c2) at least a part of the solvent, if required a part of the catalyst (mixture), if required at least a part of the polymerization inhibitor (mixture) and at least a part of the alcohol are initially taken in the esterification reactor and heated to the boiling point of the component having the lowest boiling point in the system and, as soon as the circulation is in operation, (meth)acrylic acid and, if required, the remaining alcohol and, if required, residual catalyst, polymerization inhibitor and solvent are metered in together or separately, or c3) at least a part of the solvent, at least a part of the catalyst (mixture), at least a part of the polymerization inhibitor (mixture) and at least a part of the (meth)acrylic acid are initially taken in the esterification reactor and heated to the boiling point of the component having the lowest boiling point in the system and, as soon as the circulation is in operation, the alcohol and, if required, the remaining (meth)acrylic acid and, if required, residual catalyst, polymerization inhibitor and solvent are metered in together or separately, or c4) at least a part of the solvent, at least a part of the catalyst (mixture), at least a part of the polymerization inhibitor (mixture), at least a part of the alcohol and a part of the (meth)acrylic acid are initially taken in the esterification reactor and heated to the boiling point of the component having the lowest boiling point in the system and, as soon as the circulation is in operation, if required the remaining alcohol and the remaining (meth)acrylic acid and, if required, residual catalyst, polymerization inhibitor and solvent are metered in together or separately.

  通过在至少一个酸性催化剂和至少一个聚合抑制剂的存在下，以及在与水形成共沸混合物的溶剂的存在下，通过反应（甲基）丙烯酸和醇制备较高的（甲基）丙烯酸酯，并蒸馏和冷凝共沸混合物，冷凝物分离成水相和有机相的过程，其中a)在具有循环蒸发器的反应器中进行酯化反应，并且b)在至少10%的溶剂存在下，基于反应混合物的重量，取所需的溶剂的一部分，如有必要，取所需的催化剂（混合物）的一部分，如有必要，取所需的聚合抑制剂（混合物）的一部分最初放入酯化反应器中并加热至系统中沸点最低的组分的沸点，一旦循环运行，（甲基）丙烯酸和醇以及如有必要的残余催化剂、聚合抑制剂和溶剂一起或分别计量，或c2）至少取所需的溶剂的一部分，如有必要取所需的催化剂（混合物），如有必要取所需的聚合抑制剂（混合物）和至少取所需的醇的一部分最初放入酯化反应器中并加热至系统中沸点最低的组分的沸点，一旦循环运行，（甲基）丙烯酸和如有必要的剩余醇以及如有必要的残余催化剂、聚合抑制剂和溶剂一起或分别计量，或c3）至少取所需的溶剂的一部分，至少取所需的催化剂（混合物）的一部分，至少取所需的聚合抑制剂（混合物）的一部分和至少取（甲基）丙烯酸的一部分最初放入酯化反应器中并加热至系统中沸点最低的组分的沸点，一旦循环运行，醇和如有必要的剩余（甲基）丙烯酸以及如有必要的残余催化剂、聚合抑制剂和溶剂一起或分别计量，或c4）至少取所需的溶剂的一部分，至少取所需的催化剂（混合物）的一部分，至少取所需的聚合抑制剂（混合物）的一部分，至少取所需的醇的一部分和（甲基）丙烯酸的一部分最初放入酯化反应器中并加热至系统中沸点最低的组分的沸点，一旦循环运行，如有必要，剩余的醇和剩余的（甲基）丙烯酸以及如有必要的残余催化剂、聚合抑制剂和溶剂一起或分别计量。
• Production process for hydroxyalkyl (meth) acrylate
  申请人：Nippon Shokubai Co., Ltd.

  公开号：US20040030180A1

  公开（公告）日：2004-02-12

  There is disclosed a novel production process for a hydroxyalkyl (meth)acrylate in which: the diffusion of harmful substances due to disposal of catalysts can be reduced; and also the amount of the catalyst as used can be greatly saved in the entire production process. This production process comprises the step of carrying out a reaction between (meth)acrylic acid and an alkylene oxide in the presence of a catalyst in order to produce the hydroxyalkyl (meth)acrylate; with the production process being characterized by further comprising the step of recovering the catalyst as has been used for the reaction.

  揭示了一种新型的羟基烷基（甲基）丙烯酸酯的生产工艺，其中：可以减少由于催化剂废弃而导致有害物质的扩散；同时在整个生产过程中也可以大大节省所使用的催化剂量。该生产工艺包括在催化剂存在下进行丙烯酸和烷基氧化物之间的反应，以生产羟基烷基（甲基）丙烯酸酯；该生产工艺的特点是进一步包括回收已用于反应的催化剂的步骤。