N,N-diacetyl-2,6-dichloroaniline | 91573-20-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diacetyl-2,6-dichloroaniline
• 英文别名: 2,6-dichloro-diacetanilide；2,6-Dichlorodiacetanilide；N-acetyl-N-(2,6-dichlorophenyl)acetamide
• CAS: 91573-20-5
• 化学式: C₁₀H₉Cl₂NO₂
• 分子量: 246.093
• InChiKey: CKPQWEDVABNFEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-diacetyl-2,6-dichloroaniline 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 2,6-二氯苯胺
  参考文献：
  名称：

  Synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines

  摘要：

  A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines have been prepared via the selective para dehalogenation of the corresponding anilines. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the choice of formate hydrogen donor, Pd catalyst, solvent, and temperature upon the efficiency and selectivity of the dehalogenation are discussed.

  DOI：

  10.1016/s0040-4020(01)80400-2
• 作为产物：
  描述：

  2,4,6-三氯苯胺 在 palladium on activated charcoal 甲烷磺酸 、 sodium formate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 N,N-diacetyl-2,6-dichloroaniline
  参考文献：
  名称：

  Synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines

  摘要：

  A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines have been prepared via the selective para dehalogenation of the corresponding anilines. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the choice of formate hydrogen donor, Pd catalyst, solvent, and temperature upon the efficiency and selectivity of the dehalogenation are discussed.

  DOI：

  10.1016/s0040-4020(01)80400-2

文献信息

• Ayyangar, Nagaraj R.; Srinivasan, Kumar V., Canadian Journal of Chemistry, 1984, vol. 62, p. 1292 - 1296
  作者：Ayyangar, Nagaraj R.、Srinivasan, Kumar V.

  DOI：——

  日期：——
• A novel synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines
  作者：R. Garth Pews、James E. Hunter、Richard M. Wehmeyer

  DOI：10.1016/0040-4039(91)80473-j

  日期：1991.12
• Hanson, James R.; Saberi, Hamid, Journal of Chemical Research, 2004, # 10, p. 699 - 701
  作者：Hanson, James R.、Saberi, Hamid

  DOI：——

  日期：——
• AYYANGAR, NAGARAJ, R.;SRINIVASAN, KUMAR, V., CAN. J. CHEM., 1984, 62, N 7, 1292-1296
  作者：AYYANGAR, NAGARAJ, R.、SRINIVASAN, KUMAR, V.

  DOI：——

  日期：——
• DOMNARIU, MARIOARA;KOYENDI, ALEXANDRU;DASOVEANU, MIHAELA;SZASZ, DOINA;RAD+
  作者：DOMNARIU, MARIOARA、KOYENDI, ALEXANDRU、DASOVEANU, MIHAELA、SZASZ, DOINA、RAD+

  DOI：——

  日期：——