4,4'-Bis(N-methylamino)octafluorobiphenyl | 67986-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-Bis(N-methylamino)octafluorobiphenyl
• 英文别名: 4,4'-Bis-(N-methylamino)-oktafluorobiphenyl；2,3,5,6-tetrafluoro-N-methyl-4-[2,3,5,6-tetrafluoro-4-(methylamino)phenyl]aniline
• CAS: 67986-80-5
• 化学式: C₁₄H₈F₈N₂
• 分子量: 356.218
• InChiKey: JGIPDZMKWFUYIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4,4'-Bis(N-methylamino)octafluorobiphenyl 在 盐酸 、 sodium nitrite 作用下， 反应 1.0h， 以75%的产率得到4,4'-bis(N-nitroso-N-methylamino)octafluorobiphenyl
  参考文献：
  名称：

  Polyfluorinated arylnitrosamines

  摘要：

  N-Methyl-, N-n-butyl-, N-t-butylperfluoroarylamines undergo nitrosation with nitrous acid to give the corresponding N-nitroso derivatives. Perfluoroaryl groups were selected from the benzene, indane, biphenyl, naphthalene and pyridine series. According to H-1 and F-19 NMR spectra, N-nitroso-N-methyl derivatives of polyfluoroarenes, consist of E and Z isomers with the former prevailing. The more bulky n-butyl group promotes an increase in the formation of Z isomers. Only Z isomers have been obtained from N-t-butyl derivatives of perfluorinated 4-toluidine and 4-aminopyridine. The structure of the Z isomer of N-nitroso-N-methylperfluoro-4-toluidine is confirmed by X-ray data. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00567-x
• 作为产物：
  描述：

  十氟联苯 、 甲胺 以 水 、 异丙醇 为溶剂， 反应 720.0h， 以97%的产率得到4,4'-Bis(N-methylamino)octafluorobiphenyl
  参考文献：
  名称：

  Polyfluorinated arylnitramines

  摘要：

  N-methyl- and N-butylperfluoroarylamines are transformed by HNO3 into N-nitro-N-methyl- and N-nitro-N-butylperfluoroarylamines. These reactions were used to synthesise N-nitro-N-methylpentafluoroaniline and its p-CF3. -CN, -C6F5 substituted derivatives, N-nitro-N-methylperfluoro-2,4-xylidine, N-nitro-N-methyl-4-aminotetrafluoropyridine N-nitro-N-methyl 5-aminoperfluoroindane, N-nitro-N-methyl-2- aminoheptafluoronaphthalene. 4,4 ' -bis(N-nitro-N- merhylamino)octafluorobiphenyl from 4,4 ' -bis(N-methylamino)octafluorobiphenyl, N-nitro-N-n-butylpentafluoroaniline, N-nitro-N-n-butylperfluoro-p-toluidine, N-nitro-N-n-butyl-4-aminotetrafluoropyridine and N-nitro-bis( perfluoro-p-tolyl)amine. Tetrafluoro-p-benzoquinone and heptafluoro-p-toluquinol were obtained from N-methylpentafluoroanilinz and N-methylperfluoro-p-toluidine, respectively, under the action of a mixture of HNO3 and H2SO4 The X-ray crystal structure of N-nitro-N-methylperfluoro-p-toluidine was determined. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00367-0

文献信息

• CELL CULTURE SUBSTRATE CONTAINING FLUORINE-CONTAINING POLYMER ON SURFACE
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP3135752A1

  公开（公告）日：2017-03-01

  This invention provides a cell culture substrate comprising on its surface a fluorine-containing polymer that enables three-dimensional tissue culture. The cell culture substrate of the invention has a surface at least a part of which is composed of a resin composition comprising a fluorine-containing polymer having one or more fluorine atoms in a repeating unit and exhibits the oxygen gas permeability of 219 cm3 (STP)/(m2·24h·atm) or higher. Three-dimensional tissue can be formed via cell culture with the use of the cell culture substrate of the invention.

  本发明提供了一种细胞培养基质，其表面由含氟聚合物组成，可进行三维组织培养。本发明的细胞培养基底的表面至少有一部分是由树脂组合物构成的，该树脂组合物包括在重复单元中含有一个或多个氟原子的含氟聚合物，其氧气透过率为 219 cm3 (STP)/(m2-24h-atm) 或更高。使用本发明的细胞培养基底，可通过细胞培养形成三维组织。
• US8470917B2
  申请人：——

  公开号：US8470917B2

  公开（公告）日：2013-06-25
• Polyfluorinated arylnitramines
  作者：V.E Platonov、A Haas、M Schelvis、M Lieb、K.V Dvornikova、O.I Osina、Yu.V Gatilov

  DOI：10.1016/s0022-1139(01)00367-0

  日期：2001.7

  N-methyl- and N-butylperfluoroarylamines are transformed by HNO3 into N-nitro-N-methyl- and N-nitro-N-butylperfluoroarylamines. These reactions were used to synthesise N-nitro-N-methylpentafluoroaniline and its p-CF3. -CN, -C6F5 substituted derivatives, N-nitro-N-methylperfluoro-2,4-xylidine, N-nitro-N-methyl-4-aminotetrafluoropyridine N-nitro-N-methyl 5-aminoperfluoroindane, N-nitro-N-methyl-2- aminoheptafluoronaphthalene. 4,4 ' -bis(N-nitro-N- merhylamino)octafluorobiphenyl from 4,4 ' -bis(N-methylamino)octafluorobiphenyl, N-nitro-N-n-butylpentafluoroaniline, N-nitro-N-n-butylperfluoro-p-toluidine, N-nitro-N-n-butyl-4-aminotetrafluoropyridine and N-nitro-bis( perfluoro-p-tolyl)amine. Tetrafluoro-p-benzoquinone and heptafluoro-p-toluquinol were obtained from N-methylpentafluoroanilinz and N-methylperfluoro-p-toluidine, respectively, under the action of a mixture of HNO3 and H2SO4 The X-ray crystal structure of N-nitro-N-methylperfluoro-p-toluidine was determined. (C) 2001 Elsevier Science B.V. All rights reserved.
• Polyfluorinated arylnitrosamines
  作者：Vyacheslav E. Platonov、Alois Haas、Meinolf Schelvis、Max Lieb、Kira V. Dvornikova、Olga I. Osina、Tatyana V. Rybalova、Yuri V. Gatilov

  DOI：10.1016/s0022-1139(01)00567-x

  日期：2002.3

  N-Methyl-, N-n-butyl-, N-t-butylperfluoroarylamines undergo nitrosation with nitrous acid to give the corresponding N-nitroso derivatives. Perfluoroaryl groups were selected from the benzene, indane, biphenyl, naphthalene and pyridine series. According to H-1 and F-19 NMR spectra, N-nitroso-N-methyl derivatives of polyfluoroarenes, consist of E and Z isomers with the former prevailing. The more bulky n-butyl group promotes an increase in the formation of Z isomers. Only Z isomers have been obtained from N-t-butyl derivatives of perfluorinated 4-toluidine and 4-aminopyridine. The structure of the Z isomer of N-nitroso-N-methylperfluoro-4-toluidine is confirmed by X-ray data. (C) 2002 Elsevier Science B.V. All rights reserved.