N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide maleate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide maleate
• 英文别名: (Z)-but-2-enedioic acid;N-[(1R)-1-[4-[[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl]phenyl]ethyl]methanesulfonamide
• 化学式: (x)C₄H₄O₄*C₂₀H₂₅FN₂O₃S
• 分子量: 508.6
• InChiKey: LQAMWHULUZTCMH-GFMGDHOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.72
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (2S)-4-苄基-2-(4-氟苯基)吗啉 在 1-氯乙基氯甲酸酯 、 三乙胺 作用下， 以 顺-1,2-二氯乙烯 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 7.0h， 生成 N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide maleate
  参考文献：
  名称：

  [EN] NOVEL MORPHOLINYL DERIVATIVES USEFUL AS MOGAT-2 INHIBITORS
  [FR] NOUVEAUX DÉRIVÉS MORPHOLYNYLE UTILES COMME INHIBITEURS DE MOGAT-2

  摘要：

  本发明提供了式I的化合物或其药用盐，使用这些化合物治疗高甘油三酯血症的方法；以及制备这些化合物的方法。

  公开号：

  WO2013116065A1

文献信息

• NOVEL MORPHOLINYL DERIVATIVES USEFUL AS MOGAT-2 INHIBITORS
  申请人：Eli Lilly and Company

  公开号：US20150005305A1

  公开（公告）日：2015-01-01

  The present invention provides compounds of Formula I or a pharmaceutical salt thereof, methods of treating hypertriglyceridemia using the compounds; and a process for preparing the compounds.

  本发明提供了I式化合物或其药用盐，使用这些化合物治疗高甘油三酯血症的方法；以及制备这些化合物的过程。
• THERMALLY REARRANGED POLY(BENZOXAZOLE-IMIDE) COPOLYMER HAVING CROSS-LINKED STRUCTURE, GAS SEPARATION MEMBRANE COMPRISING SAME AND PREPARATION METHOD THEREFOR
  申请人：IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

  公开号：EP3070113A1

  公开（公告）日：2016-09-21

  The present disclosure relates to a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer membrane prepared simply by heat-treating a membrane prepared from an o-hydroxypolyimide copolymer having carboxylic acid groups such that thermal crosslinking and thermal rearrangement occur simultaneously or a gas separation membrane containing a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer having a benzoxazole group content of less than 80% in the polymer chain, prepared from transesterification crosslinking of an o-hydroxypolyimide copolymer having carboxylic acid groups and a diol-based compound followed by thermal rearrangement, and a method for preparing the same (a membrane for flue gas separation is excluded). In accordance with the present disclosure, a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer membrane for gas separation can be prepared simply through heat treatment without requiring a complicated process such as chemical crosslinking, UV irradiation, etc. for forming a crosslinked structure and a gas separation membrane (a membrane for flue gas separation is excluded) prepared therefrom exhibits superior permeability and selectivity. Also, the method is applicable to commercial-scale production because the preparation process is simple.

  本公开涉及一种交联的热重排聚（苯并恶唑-酰亚胺）共聚物膜，其制备方法很简单，即对由具有羧酸基团的邻羟基聚酰亚胺共聚物制备的膜进行热处理，使热交联和热重排同时发生，或者制备一种含有交联的热重排聚（苯并恶唑-酰亚胺）共聚物的气体分离膜、由具有羧酸基团的邻羟基聚酰亚胺共聚物和二元醇基化合物经酯交换交联后再进行热重排制备的聚合物链中苯并恶唑基团含量低于80%的热重排聚（苯并恶唑-酰亚胺）共聚物，以及制备该共聚物的方法（不包括用于烟气分离的膜）。 根据本公开内容，一种用于气体分离的交联热重排聚（苯并恶唑-酰亚胺）共聚物膜只需通过热处理即可制备，无需复杂的化学交联、紫外线照射等形成交联结构的过程，由此制备的气体分离膜（不包括用于烟气分离的膜）具有优异的渗透性和选择性。此外，由于制备过程简单，该方法适用于商业规模的生产。
• Membranes for flue gas separation comprising crosslinked, thermally rearranged poly(benzoxazole-co-imide) and preparation method thereof
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US10040034B2

  公开（公告）日：2018-08-07

  The present disclosure relates to a membrane for flue gas separation containing a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer prepared simply by heat-treating a membrane prepared from an o-hydroxypolyimide copolymer having carboxylic acid groups such that thermal crosslinking and thermal rearrangement occur simultaneously or a membrane for flue gas separation containing a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer having a benzoxazole group content of less than 80% in the polymer chain, prepared from transesterification crosslinking of an o-hydroxypolyimide copolymer having carboxylic acid groups and a diol-based compound followed by thermal rearrangement, and a method for preparing the same. In accordance with the present disclosure, a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer membrane for flue gas separation can be prepared simply through heat treatment without requiring a complicated process such as chemical crosslinking, UV irradiation, etc. for forming a crosslinked structure and a membrane for flue gas separation prepared therefrom exhibits superior permeability and selectivity. Also, the method is applicable to commercial-scale production because the preparation process is simple.

  本公开涉及一种用于烟气分离的膜，该膜含有一种交联的热重排聚（苯并恶唑-酰亚胺）共聚物，其制备方法很简单，即对由具有羧酸基团的邻羟基聚酰亚胺共聚物制备的膜进行热处理，使热交联和热重排同时发生，或者涉及一种用于烟气分离的膜，该膜含有一种交联的热重排聚（苯并恶唑-酰亚胺）共聚物，其制备方法很简单，即对由具有羧酸基团的邻羟基聚酰亚胺共聚物制备的膜进行酯化交联、由具有羧酸基团的邻羟基聚酰亚胺共聚物和二元醇基化合物经酯交换交联后再进行热重排制备的聚合物链中苯并恶唑基团含量低于80%的热重排聚（苯并恶唑-酰亚胺）共聚物，以及制备该共聚物的方法。 根据本公开内容，可通过热处理简单地制备用于烟气分离的交联热重排聚（苯并恶唑-酰亚胺）共聚物膜，而无需复杂的化学交联、紫外线照射等形成交联结构的过程，由此制备的烟气分离膜具有优异的渗透性和选择性。此外，由于制备工艺简单，该方法适用于商业规模生产。
• Crosslinked, thermally rearranged poly(benzoxazole-co-imide), gas separation membranes comprising the same and preparation method thereof
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US10035109B2

  公开（公告）日：2018-07-31

  The present disclosure relates to a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer membrane prepared simply by heat-treating a membrane prepared from an o-hydroxypolyimide copolymer having carboxylic acid groups such that thermal crosslinking and thermal rearrangement occur simultaneously or a gas separation membrane containing a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer having a benzoxazole group content of less than 80% in the polymer chain, prepared from transesterification crosslinking of an o-hydroxypolyimide copolymer having carboxylic acid groups and a diol-based compound followed by thermal rearrangement, and a method for preparing the same (a membrane for flue gas separation is excluded). In accordance with the present disclosure, a crosslinked, thermally rearranged poly(benzoxazole-co-imide) copolymer membrane for gas separation can be prepared simply through heat treatment without requiring a complicated process such as chemical crosslinking, UV irradiation, etc. for forming a crosslinked structure and a gas separation membrane (a membrane for flue gas separation is excluded) prepared therefrom exhibits superior permeability and selectivity. Also, the method is applicable to commercial-scale production because the preparation process is simple.

  本公开涉及一种交联的热重排聚（苯并恶唑-酰亚胺）共聚物膜，其制备方法很简单，即对由具有羧酸基团的邻羟基聚酰亚胺共聚物制备的膜进行热处理，使热交联和热重排同时发生，或者制备一种含有交联的热重排聚（苯并恶唑-酰亚胺）共聚物的气体分离膜、由具有羧酸基团的邻羟基聚酰亚胺共聚物和二元醇基化合物经酯交换交联后再进行热重排制备的聚合物链中苯并恶唑基团含量低于80%的热重排聚（苯并恶唑-酰亚胺）共聚物，以及制备该共聚物的方法（不包括用于烟气分离的膜）。 根据本公开内容，一种用于气体分离的交联热重排聚（苯并恶唑-酰亚胺）共聚物膜只需通过热处理即可制备，无需复杂的化学交联、紫外线照射等形成交联结构的过程，由此制备的气体分离膜（不包括用于烟气分离的膜）具有优异的渗透性和选择性。此外，由于制备过程简单，该方法适用于商业规模的生产。
• Thermally rearranged poly(benzoxazoleco-imide) separation membrane for membrane distillation and fabrication method thereof
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US10071346B2

  公开（公告）日：2018-09-11

  The present invention relates to the production of a hydroxyl polyimide-co-polyimide membrane, the fabrication of a thermally rearranged poly(benzoxazole-co-imide) membrane by thermally treating the hydroxyl polyimide-co-polyimide membrane, and the application of the thermally rearranged poly(benzoxazole-co-imide) membrane to membrane distillation. The thermally rearranged poly(benzoxazole-co-imide) separation membrane has high liquid entry pressure, low thermal conductivity, high permeate flux, and good long-term stability, as well as excellent thermal and chemical properties. Due to these advantages, the copolymer separation membrane can be applied to membrane distillation processes.

  本发明涉及羟基聚酰亚胺-共聚酰亚胺膜的生产，通过热处理羟基聚酰亚胺-共聚酰亚胺膜制备热重排聚（苯并恶唑-共聚酰亚胺）膜，以及将热重排聚（苯并恶唑-共聚酰亚胺）膜应用于膜蒸馏。热重排聚（苯并恶唑-共亚胺）分离膜具有较高的液体进入压力、较低的热导率、较高的渗透通量和良好的长期稳定性，以及优异的热性能和化学性能。由于这些优点，共聚物分离膜可应用于膜蒸馏过程。