7-Cinnamoyloxycumarin | 36323-88-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-Cinnamoyloxycumarin
• 英文别名: 7-[(E)-3-phenylprop-2-enoxy]chromen-2-one
• CAS: 36323-88-3
• 化学式: C₁₈H₁₄O₃
• 分子量: 278.307
• InChiKey: JCIIRNVOQBXRNF-QPJJXVBHSA-N

物化性质

• 沸点：
  489.0±45.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Cinnamoyloxycumarin 以 N,N-二乙基苯胺 为溶剂， 反应 2.0h， 以55%的产率得到7-hydroxy-8-(1'-phenylprop-2'-ene)coumarin
  参考文献：
  名称：

  Application of the BHQ benzannulation reaction to the synthesis of benzo-fused coumarins

  摘要：

  A new approach to the synthesis of the 6H-benzo[d]naphthal[,2-b]pyran-6-one ring system present in the gilvocarcin family of antibiotics is described. The key feature of this approach is the application of a new benzannulation strategy (the 'BHQ Reaction') whereby readily available ortho-allylaryl trichloroacetates are transformed into naphthalene derivatives via a cascade of reactions involving an initial ATRC reaction followed by the extrusion of CO2. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.077
• 作为产物：
  描述：

  肉桂基氯 、 7-羟基香豆素 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以61%的产率得到7-Cinnamoyloxycumarin
  参考文献：
  名称：

  Application of the BHQ benzannulation reaction to the synthesis of benzo-fused coumarins

  摘要：

  A new approach to the synthesis of the 6H-benzo[d]naphthal[,2-b]pyran-6-one ring system present in the gilvocarcin family of antibiotics is described. The key feature of this approach is the application of a new benzannulation strategy (the 'BHQ Reaction') whereby readily available ortho-allylaryl trichloroacetates are transformed into naphthalene derivatives via a cascade of reactions involving an initial ATRC reaction followed by the extrusion of CO2. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.077

文献信息

• [EN] SKIN PIGMENTATION MODIFIERS TO DARKEN OR LIGHTEN THE SKIN<br/>[FR] AGENTS DE MODIFICATION DE LA PIGMENTATION DE LA PEAU EN VUE DE L'ASSOMBRIR OU DE L'ÉCLAIRCIR
  申请人：AFFICHEM

  公开号：WO2016193220A1

  公开（公告）日：2016-12-08

  The present invention relates to a method for changing the pigmentation of a skin, a mucous membrane or hair with a compound of general formula (I), a cosmetic use of said compound of general formula (I), to cosmetic compositions comprising said compound of general formula (I), and to new depigmenting agents.

  本发明涉及一种改变皮肤、粘膜或头发色素的方法，使用一般式(I)的化合物，以及所述一般式(I)的化合物的化妆用途，包括所述一般式(I)的化合物的化妆组合物，以及新的脱色剂。
• Microwave and BF3 Promoted Rearrangement of Allyloxycoumarins to Allylcoumarins and Dihydrofurocoumarins
  作者：Mohammad R. Saidi、Fatemeh Rajabi

  DOI：10.3987/com-01-9265

  日期：——