(cis-4-(allyloxy)cyclohexyl)benzene | 1624284-58-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (cis-4-(allyloxy)cyclohexyl)benzene
• 英文别名: allyl cis-4-phenylcyclohexyl ether
• CAS: 1624284-58-7
• 化学式: C₁₅H₂₀O
• 分子量: 216.323
• InChiKey: RQMUZCKDOCKQGK-GASCZTMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (cis-4-(allyloxy)cyclohexyl)benzene 在 亚硝酸特丁酯 、 2,2,6,6-四甲基哌啶氧化物 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 41.5h， 生成 3-ethyl-1-(1-nitro-3-{[(cis)-4-phenylcyclohexyl]oxy}propan-2-yl)-1,2-dihydropyridin-2-one
  参考文献：
  名称：

  [EN] SULFONAMIDE OREXIN RECEPTOR AGONISTS AND USES THEREOF
  [FR] AGONISTES DU RÉCEPTEUR DE L'OREXINE À BASE DE SULFONAMIDE ET LEURS UTILISATIONS

  摘要：

  Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, A, L1, L2, Y and Z are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a disease or disorder that is treatable by administration of an Orexin agonist.

  公开号：

  WO2022269049A1
• 作为产物：
  描述：

  4-苯基环己酮 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 3.0h， 生成 (cis-4-(allyloxy)cyclohexyl)benzene
  参考文献：
  名称：

  Repairing the Thiol-Ene Coupling Reaction

  摘要：

  AbstractThiol‐ene coupling (TEC) reactions emerged as one of the most useful processes for coupling different molecular units under reaction mild conditions. However, TEC reactions involving weak CH bonds (allylic and benzylic fragments) are difficult to run and often low yielding. Mechanistic studies demonstrate that hydrogen‐atom transfer processes at allylic and benzylic positions are responsible for the lack of efficiency of the radical‐chain process. These competing reactions cannot be prevented, but reported herein is a method to repair the chain process by running the reaction in the presence of triethylborane and catechol. Under these reaction conditions, a unique repair mechanism leads to an efficient chain reaction, which is demonstrated with a broad range of anomeric O‐allyl sugar derivatives including mono‐, di‐, and tetrasaccharides bearing various functionalities and protecting groups.

  DOI：

  10.1002/anie.201309984

文献信息

• HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20200385346A1

  公开（公告）日：2020-12-10

  The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

  本发明提供了一种具有促进促进素2型受体激动剂活性的杂环化合物。式（I）所表示的化合物：其中每个符号如规范所述，或其盐，具有促进促进素2型受体激动剂活性，并且可用作预防或治疗嗜睡症的药物。
• Heterocyclic compound and application thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US11319286B2

  公开（公告）日：2022-05-03

  The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

  本发明提供了一种具有奥曲肽 2 型受体激动剂活性的杂环化合物。 由式（I）代表的化合物： 其中各符号如说明书所述，或其盐具有奥曲肽 2 型受体激动剂活性，可用作预防或治疗嗜睡症的药物。