phenylsulfonyl-2-azetidinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: phenylsulfonyl-2-azetidinone
• 英文别名: 1-(Benzenesulfonyl)azetidin-2-one
• 化学式: C₉H₉NO₃S
• 分子量: 211.241
• InChiKey: VKIOSFOKYKUOIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenylsulfonyl-2-azetidinone 、 乙烯基溴化镁 以 四氢呋喃 为溶剂， 反应 1.17h， 以62%的产率得到4-乙烯氮杂啶-2-酮
  参考文献：
  名称：

  [EN] 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS
  [FR] 2-CYANOPYRROLES ET LEURS ANALOGUES EN TANT QU'INHIBITEURS DE DIPEPTIDYLPEPTIDASE-IV (DP-IV)

  摘要：

  本发明涉及具有以下式I的治疗活性和选择性抑制剂的酶DPP-IV。此外，本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制造用于治疗与DPP-IV使蛋白质失活相关的疾病的药物，例如2型糖尿病和肥胖症。

  公开号：

  WO2004089362A1

文献信息

• Reactive liquid polymer crosslinking agent and process for preparation
  申请人：——

  公开号：US20030168629A1

  公开（公告）日：2003-09-11

  A reactive liquid crosslinking agent for use in the preparation of polymeric substances. The crosslinking agent comprises a substituted 1,3,5 Triazine reacted with water, an acid alkyl sulfonate and/or phosphonate and a solidifying modifier containing an hydroxyl functional group. The reactive liquid polymer crosslinking agent has a solids content between 20-99% solids. The reactive liquid crosslinking agents (RLPC's) are useful as modifiers in the preparation of polymeric compounds which are suitable for one-component self-crosslinking adhesives, coatings and polymers used in optics, textiles, composites, casting and molding. RLPC systems containing from 1-30% RLPC provide fast single package thermosetting polymeric compounds with enhanced properties such as chemical, heat and abrasion resistance.
• US4882429A
  申请人：——

  公开号：US4882429A

  公开（公告）日：1989-11-21
• [EN] REACTIVE LIQUID POLYMER CROSSLINKING AGENT AND PROCESS FOR PREPARATION<br/>[FR] AGENT DE RETICULATION POLYMERE LIQUIDE, REACTIF ET PROCEDE DE PREPARATION
  申请人：LCB WORLDWIDE INC

  公开号：WO2003050094A1

  公开（公告）日：2003-06-19

  A reactive liquid crosslinking agent for use in the preparation of polymeric substances. The crosslinking agent comprises a substituted 1,3,5 Triazine reacted with water, an acid alkyl sulfonate and/or phosphonate and a solidifying modifier containing an hydroxyl functional group. The reactive liquid polymer crosslinking agent has a solids content between 20-99 % solids. The reactive liquid crosslinking agents (RLPC's) are useful as modifiers in the preparation of polymeric compounds which are suitable for one-component self-crosslinking adhesives, coatings and polymers used in optics, textiles, composites, casting and molding. RLPC systems containing from 1-30 % RLPC provide fast single package thermosetting polymeric compounds with enhanced properties such as chemical, heat and abrasion resistance.
• [EN] 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS<br/>[FR] 2-CYANOPYRROLES ET LEURS ANALOGUES EN TANT QU'INHIBITEURS DE DIPEPTIDYLPEPTIDASE-IV (DP-IV)
  申请人：NOVO NORDISK AS

  公开号：WO2004089362A1

  公开（公告）日：2004-10-21

  The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV having the formula I: (I) The invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of such compounds for the manufacture of medicaments for treating diseases that are associated with proteins which are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity.

  本发明涉及具有以下式I的治疗活性和选择性抑制剂的酶DPP-IV。此外，本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制造用于治疗与DPP-IV使蛋白质失活相关的疾病的药物，例如2型糖尿病和肥胖症。