5-aminosalicylic acid hydrochloride | 6291-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-aminosalicylic acid hydrochloride
• 英文别名: 5-amino-2-hydroxy-benzoic acid ; hydrochloride；5-Amino-2-hydroxy-benzoesaeure; Hydrochlorid；salzsaure 5-Amino-salicylsaeure；5-Amino-2-hydroxybenzoic acid;hydron;chloride
• CAS: 6291-36-7
• 化学式: C₇H₇NO₃*ClH
• mdl: MFCD01684523
• 分子量: 189.598
• InChiKey: KKRSNTURHSOKTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.29
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-aminosalicylic acid hydrochloride 在 乙醇 、 溶剂黄146 作用下， 生成 2-hydroxy-5-(4-nitro-benzylidenamino)-benzoic acid
  参考文献：
  名称：

  Pope, Journal of the Chemical Society, 1908, vol. 93, p. 537

  摘要：

  DOI：

文献信息

• Oligo(ethylene glycol)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers
  申请人：——

  公开号：US20030044402A1

  公开（公告）日：2003-03-06

  The present invention provides biotechnologically useful oligo(ethylene glycol)-terminated 1,2-dithiolane compositions and conjugates of these compositions with biological or non-biological receptor, ligand, sequestering, or reporter moieties. The invention also provides methods for the preparation of these compositions. Further, the invention provides self-assembled monolayer (SAM) compositions on a metal and methods for their preparation.

  本发明提供了具有生物技术应用的寡聚（乙二醇）-终止的1,2-二硫杂环烷组合物以及这些组合物与生物或非生物受体、配体、隔离或报告分子的结合物。本发明还提供了制备这些组合物的方法。此外，本发明还提供了在金属上的自组装单分子层（SAM）组合物及其制备方法。
• Peptide substrates for determination of enzyme activity
  申请人：Nitto Boseki Co., Ltd.

  公开号：US05116941A1

  公开（公告）日：1992-05-26

  Compounds represented by the following formula: ##STR1## wherein A.sub.1 and A.sub.2 each represents a specific amino acid residue, are excellent as substrates for determination of enzyme activity such as trypsin, etc.

  以下化学式所代表的化合物：##STR1## 其中A.sub.1和A.sub.2分别代表特定的氨基酸残基，非常适合作为测定酶活性（如胰蛋白酶等）的底物。
• Novel substrate for determining the activity of blood coagulation factor
  申请人：Nitto Poseki Co., Ltd.

  公开号：US04622389A1

  公开（公告）日：1986-11-11

  A novel chromogenic and fluorescent substrate for determining the activity of blood coagulation factor Xa and Xa-like enzymes. The novel substrate according to the present invention has very excellent selectivity as compared with the hitherto disclosed substrates and enables specific determination of blood coagulation factor Xa. The present substrate is therefore useful for the studies of chemical reactions involving formation, inhibition and consumption of factor Xa and can be also used for the determination of various factors associated therewith such as factor X, anti-Xa factor, factor VII, factor VIII, factor IX and heparin.

  一种新型的显色和荧光底物，用于测定血液凝血因子Xa和Xa样酶的活性。根据本发明，这种新型底物与迄今公开的底物相比具有非常优异的选择性，能够特异性地测定血液凝血因子Xa。因此，本底物对于研究涉及因子Xa的形成、抑制和消耗的化学反应非常有用，也可用于测定与之相关的各种因子，如因子X、抗Xa因子、VII因子、VIII因子、IX因子和肝素。
• Novel method for determination of 5-aminosalicylic acid
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0094789A1

  公开（公告）日：1983-11-23

  A novel method for the determination of 5-aminosalicyclic acid, which comprises measuring the color developed in an alkaline medium by an oxidative condensation product formed by the condensation of an o-alkylphenol represented by the general formula (wherein R1 represents an ethyl, isopropyl or sec-butyl group) with 5-aminosalicyclic acid of the formula in the presence of a peroxide.

  一种测定 5-氨基水杨酸的新方法，它包括测定由通式如下的邻烷基酚（其中 R1 代表乙基、异丙基或仲丁基）与式 5-氨基水杨酸缩合形成的氧化缩合产物在碱性介质中显现的颜色 (其中 R1 代表乙基、异丙基或仲丁基）与式 5-氨基水杨酸在过氧化物存在下的氧化缩合产物。 在过氧化物存在下的缩合产物。
• Novel substrate for determining the activity of blood coagulation factor Xa (Stuart-Prower Factor)
  申请人：NITTO BOSEKI CO., LTD.

  公开号：EP0170797A1

  公开（公告）日：1986-02-12

  A novel chromogenic and fluorescent substrate for determining the activity of blood coagulation factor Xa and Xa-like enzymes. The novel substrate according to the present invention has very excellent selectivity as compared with the hitherto disclosed substrates and enables specific determination of blood coagulation factor Xa. The present substrate is therefore useful for the studies of chemical reactions involving formation, inhibition and consumption of factor Xa and can be also used for the determination of various factors associated therewith such as factor X, anti-Xa factor, factor VII, factor VIII, factor IX and heparin.

  一种用于测定血液凝固因子 Xa 和 Xa 样酶活性的新型发色性和荧光底物。 与迄今已公开的底物相比，本发明的新型底物具有极佳的选择性，能够特异性地测定血液凝固因子 Xa。 因此，本发明的底物可用于研究涉及因子 Xa 的形成、抑制和消耗的化学反应，也可用于测定与之相关的各种因子，如因子 X、抗 Xa 因子、因子 VII、因子 VIII、因子 IX 和肝素。