2,4-di-tert-butyl-6-(phenyl(piperidin-1-yl)methyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-6-(phenyl(piperidin-1-yl)methyl)phenol
• 英文别名: 2,4-di-tert-butyl-6-(phenylpiperidin-1-yl-methyl)phenol；2,4-Di-tert-butyl-6-(phenyl-piperidin-1-yl-methyl)-phenol；2,4-ditert-butyl-6-[phenyl(piperidin-1-yl)methyl]phenol
• 化学式: C₂₆H₃₇NO
• 分子量: 379.586
• InChiKey: ODPQEIZISSLBMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-di-tert-butyl-6-(phenyl(piperidin-1-yl)methyl)phenol 、 3-巯基丙酸丁酯 以 甲苯 为溶剂， 生成 3-[(3,5-di-tert-butyl-2-hydroxyphenyl)phenylmethylsulfanyl]-propionic acid butyl ester
  参考文献：
  名称：

  A Concise, Novel Route to 1,3-Benzoxathian Derivatives

  摘要：

  通过串联闭环/δ-消除途径，从容易获得的邻硫代苯酚中以一锅法成功制备了新型 1,3-苯并噁噻衍生物。

  DOI：

  10.1055/s-0029-1217016
• 作为产物：
  描述：

  哌啶 、 2,4-二叔丁基苯酚 、 苯甲醛 以 苯 为溶剂， 反应 16.0h， 以72%的产率得到2,4-di-tert-butyl-6-(phenyl(piperidin-1-yl)methyl)phenol
  参考文献：
  名称：

  Synthesis, In silico studies and In vitro evaluation for antioxidant and antibacterial properties of diarylmethylamines: A novel class of structurally simple and highly potent pharmacophore

  摘要：

  A series of novel diarylmethylamines were synthesized via simple three component condensation reaction. In vitro antibacterial activity of the synthesized compounds was assessed against Gram-positive and Gram-negative bacteria. Compound 1f containing phenyl and N-methyl piperazine moiety was found to be potent against both pathogenic bacteria with MIC value of 31 mu g/mL. Diarylmethylamine 1l containing sesamol and N-methyl piperazine units was found to be the most effective against Gram-positive bacteria with MIC value of 15 mu g/mL. The compound leads to the damage of the bacterial cell membrane which was demonstrated by flow cytometry (FC) and field emission scanning electron microscopy (FESEM). Radical scavenging activity of compounds 1l and 1m was found out to be comparable with that of standard antioxidant BHT. Further, in silico studies were carried out to calculate the physico-chemical parameter of the synthesized compounds. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejps.2016.03.004

文献信息

• S-perfluoroalkyl substituted hydroxybenzylthioethers and derivatives as surface modifiers
  申请人：Gerster Michèle

  公开号：US20090326145A1

  公开（公告）日：2009-12-31

  The invention describes a process for reducing the surface energy of organic materials such as for example increasing the oil and water repellency and stain release of organic materials, which comprises treating the organic material with at least a compound of the formula I wherein the general symbols are as defined in claim 1; especially wherein at least one of the radicals R 2 , R 3 or R 4 is —CH(R 11 )—S(O) p —R 12 ; R 11 is hydrogen, C 1 -C 8 alkyl, unsubstituted or with C 1 -C 4 alkyl substituted phenyl; R 12 is a monovalent perfluorinated alkyl or alkenyl, linear or branched organic radical having four to twenty fully fluorinated carbon atoms, and p is 0, 1 or 2.

  该发明描述了一种降低有机材料表面能的过程，例如增加有机材料的油水抗性和防污性，并使其具有去污性，该过程包括用式I中至少一种化合物处理有机材料，其中一般符号如权利要求书中所定义；特别是其中至少一个基团R2、R3或R4是-CH(R11)-S(O)p-R12；R11是氢、C1-C8烷基，未取代或与C1-C4烷基取代的苯基；R12是具有四到二十个全氟碳原子的单价全氟烷基或烯烃基，线性或支链有机基团，p为0、1或2。
• [EN] STABILIZATION AND SURFACE MODIFICATION OF ORGANIC MATERIALS<br/>[FR] STABILISATION ET MODIFICATION DE SURFACE DE MATIÈRES ORGANIQUES
  申请人：BASF SE

  公开号：WO2009127514A1

  公开（公告）日：2009-10-22

  Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation and/or are able to reduce the surface energy of organic materials comprise at least one compound of the formula (I) wherein the general symbols are as defined in claim 1.

  具有抗氧化、热降解或光降解稳定性，或能够降低有机材料表面能的有机材料，至少包含式(I)中的一个化合物，其中一般符号如权利要求1所定义。
• Polyester and polyamide compositions of low residual aldehyde content
  申请人：Tinkl Michael

  公开号：US20050176859A1

  公开（公告）日：2005-08-11

  A mixture of a polyester or a polyamide, such as poly(ethylene terephthalate) PET, and a suitable stabilizer selected from the group consisting of certain Mannich base compounds, when extrusion compounded exhibits a lower residual acetaldehyde content than does PET or polyamide alone when similarly treated. The invention pertains to any polyester or polyamide used in the manufacture of molded articles, fibers, or films, for instance bottles or containers which are used to store consumer materials, for example food, beverages and water.

  一种由聚酯或聚酰胺混合物，例如聚对苯二甲酸乙二酯（PET），以及从某些曼尼希碱化合物组成的适当稳定剂中选择的稳定剂，在挤出混合后的残留乙醛含量比单独处理的PET或聚酰胺低。该发明涉及用于制造模塑品、纤维或薄膜的任何聚酯或聚酰胺，例如用于存储消费者材料的瓶子或容器，例如食品、饮料和水。
• POLYESTER AND POLYAMIDE COMPOSITIONS OF LOW RESIDUAL ALDEHYDE CONTENT
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1440117A2

  公开（公告）日：2004-07-28
• S-PERFLUOROALKYL SUBSTITUTED HYDROXYBENZYLTHIOETHERS AND DERIVATIVES AS SURFACE MODIFIERS
  申请人：Ciba Holding Inc.

  公开号：EP2027202A1

  公开（公告）日：2009-02-25