(2R)-2-[(trans-4-isopropyl-cyclohexanecarbonyl)amino]-3-[4-(2-(methylamino)ethoxy)phenyl]propionic acid methyl ester | 727985-91-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[(trans-4-isopropyl-cyclohexanecarbonyl)amino]-3-[4-(2-(methylamino)ethoxy)phenyl]propionic acid methyl ester
• CAS: 727985-91-3
• 化学式: C₂₃H₃₆N₂O₄
• 分子量: 404.55
• InChiKey: ZHQVIUALOKWWDN-SFHLNBCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.95
• 重原子数：
  29.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  76.66
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-氯苯并恶唑 、 (2R)-2-[(trans-4-isopropyl-cyclohexanecarbonyl)amino]-3-[4-(2-(methylamino)ethoxy)phenyl]propionic acid methyl ester 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Insulin-releasing activity of a series of phenylalanine derivatives

  摘要：

  A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds (S)-3 and (R)-3 exhibited more potent insulin-releasing activity than that of nateglinide, compound (S)-3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo. (C) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.11.018
• 作为产物：
  描述：

  (2R)-2-[(trans-4-isopropyl-cyclohexanecarbonyl)amino]-3-[4-(2-(methyl-(tert-butoxycarbonyl)amino)ethoxy)phenyl]propionic acid methyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (2R)-2-[(trans-4-isopropyl-cyclohexanecarbonyl)amino]-3-[4-(2-(methylamino)ethoxy)phenyl]propionic acid methyl ester
  参考文献：
  名称：

  Insulin-releasing activity of a series of phenylalanine derivatives

  摘要：

  A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds (S)-3 and (R)-3 exhibited more potent insulin-releasing activity than that of nateglinide, compound (S)-3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo. (C) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.11.018