8-Bromodecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Bromodecanoic acid
• 化学式: C₁₀H₁₉BrO₂
• 分子量: 251.164
• InChiKey: LSVLGIXWMQSVMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙位癸内酯 在 氢溴酸 作用下， 反应 18.0h， 生成 4-溴-癸酸 、 9-Bromodecanoic Acid 、 6-bromodecanoic acid 、 、 8-Bromodecanoic acid 、 5-bromodecanoic acid
  参考文献：
  名称：

  Granata, Alessandro; Perlin, Arthur S., Canadian Journal of Chemistry, 1993, vol. 71, # 6, p. 864 - 871

  摘要：

  DOI：

文献信息

• [EN] PHOSPHONIUM-ION TETHERED TETRACYCLINE DRUGS FOR TREATMENT OF CANCER<br/>[FR] MÉDICAMENTS DE TÉTRACYCLINE ATTACHÉS À UN ION PHOSPHONIUM POUR LE TRAITEMENT DU CANCER
  申请人：NOVINTUM BIOTECHNOLOGY GMBH

  公开号：WO2018193113A1

  公开（公告）日：2018-10-25

  This invention relates to compounds of formula (I) that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

  这项发明涉及作为癌症治疗药物有用的化合物(I)。这些化合物包括四环素抗生素的衍生物，例如强力霉素，其中磷酸铵阳离子与四环素四环相连。该发明还涉及使用这些化合物的方法，以及包含这些化合物的药物配方。
• Phosphonium-ion tethered tetracycline drugs for treatment of cancer
  申请人：Oxford University Innovation Limited

  公开号：US11161862B2

  公开（公告）日：2021-11-02

  This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

  本发明涉及可用作癌症疗法的化合物。这些化合物包括四环素类抗生素（如强力霉素）的衍生物，其鏻阳离子与四环素四环相连。本发明还涉及使用所述化合物的方法和包含所述化合物的药物制剂。
• PHOSPHONIUM-ION TETHERED TETRACYCLINE DRUGS FOR TREATMENT OF CANCER
  申请人：Rising Tide Foundation

  公开号：EP3612539A1

  公开（公告）日：2020-02-26
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US4059561A
  申请人：——

  公开号：US4059561A

  公开（公告）日：1977-11-22