N,n-dipropylthiourea | 40398-32-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: N,n-dipropylthiourea
• 英文别名: N,N-di-n-propylthiourea；1,1-dipropyl-thiourea；N,N-Dipropyl-thioharnstoff；1,1-dipropylthiourea；N,N-Di-n-propyl-thioharnstoff
• CAS: 40398-32-1
• 化学式: C₇H₁₆N₂S
• mdl: MFCD00797826
• 分子量: 160.283
• InChiKey: PBGVARFFBCBNJT-UHFFFAOYSA-N

物化性质

• 沸点：
  228.8±23.0 °C(Predicted)
• 密度：
  1.001±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,n-dipropylthiourea 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 14.0h， 生成 2-(N,N-dipropylamino)-4(1H)-quinazolinone
  参考文献：
  名称：

  Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines

  摘要：

  Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.

  DOI：

  10.1021/jm00185a026
• 作为产物：
  描述：

  二正丙胺 在 乙醚 、 硫化氢 、 氨 作用下， 生成 N,n-dipropylthiourea
  参考文献：
  名称：

  Wallach, Chemische Berichte, 1899, vol. 32, p. 1873

  摘要：

  DOI：

文献信息

• NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME
  申请人：Ryu Jei Man

  公开号：US20110306606A1

  公开（公告）日：2011-12-15

  The present invention relates to a novel 2,6-substituted-3-nitropyridine derivative compound, a method for preparing the same, and a pharmaceutical composition including the same for prevention and treatment of osteoporosis. The 2,6-substituted-3-nitropyridine derivative compound of the present invention increases osteoblast activity and effectively inhibits the differentiation of osteoclasts, and thus can be usefully used for the prevention and treatment of osteoporosis.

  本发明涉及一种新型的2,6-取代-3-硝基吡啶衍生物化合物，一种制备该化合物的方法，以及包括该化合物的用于预防和治疗骨质疏松症的药物组合物。本发明的2,6-取代-3-硝基吡啶衍生物化合物增加成骨细胞活性并有效抑制破骨细胞的分化，因此可用于预防和治疗骨质疏松症。
• Nucleophilic Substitution on Dialkoxy Disulfides. III. Reaction with Thioureas
  作者：Hiroaki Kagami、Takashi Hanzawa、Nobuo Suzuki、Shoso Yamaguchi、Masami Saito、Shinichi Motoki

  DOI：10.1246/bcsj.53.3658

  日期：1980.12

  1,3- and 1,1-Disubstituted thioureas reacted with diethoxy disulfide to give carbodiimides and 1,2,4-thiadiazoles respectively. 1,1,3-Trisubstituted thioureas and diethoxy disulfide afforded trialkyl(trialkylamidino)thioureas.

  1,3-和1,1-二取代硫脲与二乙氧基二硫化物反应分别生成碳二亚胺和1,2,4-噻二唑。1,1,3-三取代的硫脲和二乙氧基二硫化物得到三烷基（三烷基脒基）硫脲。
• ORGANOSILICON COMPOUND, METHOD FOR PRODUCING SAME AND METAL SURFACE TREATMENT AGENT USING SAME
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20170226136A1

  公开（公告）日：2017-08-10

  An organosilicon compound represented by general formula (1). The present invention is able to provide an organosilicon compound which has excellent adhesion during processing and high bonding strength, while exhibiting antirust corrosion resistance at high levels, and which is useful as a metal surface treatment agent. (In the formula, R represents a hydrolyzable group; R′ represents an alkyl group; A represents an alkylene group; R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 among the R 1 , R 2 , R 3 and R 4 moieties may combine together to form an aliphatic or aromatic ring skeleton, and in cases where a ring skeleton is not formed, each one of the R 1 , R 2 , R 3 and R 4 moieties independently represents a hydrogen atom or an alkyl group; and m represents a number of 1-3.)

  一种由通式（1）表示的有机硅化合物。本发明能够提供一种在加工过程中具有优异粘附性和高结合强度的有机硅化合物，同时在高水平上表现出抗锈蚀性，并且可用作金属表面处理剂。（在该式中，R代表一个可水解基团；R′代表一个烷基基团；A代表一个烷基基团；R1和R2、R2和R3、或R3和R4中的R1、R2、R3和R4基团中的某些基团可以结合形成一个脂肪族或芳香族环骨架，如果不形成环骨架，则R1、R2、R3和R4中的每一个基团独立地表示一个氢原子或一个烷基基团；m表示1-3之间的数字。）
• Synthesis of 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines and evaluation as potential dopamine agonists
  作者：John A. Grosso、David E. Nichols、Jai D. Kohli、Dana Glock

  DOI：10.1021/jm00348a018

  日期：1982.6

  (ADTN's), heterocyclic congeners were prepared. Several 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines were synthesized and tested for a dopamine-like vasodilatory action in the canine renal artery. The 6,7-disubstituted series had a weak antagonist effect against dopamine. Neither 5,6- nor 6,7-dihydroxy substitution gave dopamine agonists. Measured pKa values confirmed the expectation that

  基于2-氨基二羟基-1,2,3,4-四氢萘（ADTN）的已知多巴胺能性质，制备了杂环同源物。合成了几种2-（烷基氨基）-5,6-和-6,7-二羟基-3,4-二氢喹唑啉，并测试了其在犬肾动脉中的多巴胺样血管舒张作用。6,7-二取代系列对多巴胺的拮抗作用较弱。5,6-或6,7-二羟基取代均未产生多巴胺激动剂。测得的pKa值证实了人们期望二氢喹唑啉比多巴胺更碱性，这可能是缺乏多巴胺样作用的可能原因之一。
• POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL
  申请人：Suzuki Kenji

  公开号：US20120196952A1

  公开（公告）日：2012-08-02

  The present invention provides a polymerizable composition that is suitably used as a temporary cement for implant use and a mobile tooth-fixing material. The present invention is a polymerizable composition that includes an acrylic block copolymer (a) having at least one polymer block A that mainly contains a (meth)acrylic acid ester unit and that functions as a hard segment and at least one polymer block B that mainly contains an acrylic acid ester unit and that functions as a soft segment, a polymerizable monomer (b), and a polymerization initiator (c).

  本发明提供了一种可用作植入物临时粘合剂和移动牙齿固定材料的聚合物组合物。本发明是一种聚合物组合物，包括至少具有一个聚合物块A的丙烯酸酯单元(甲基)和至少一个聚合物块B的丙烯酸酯单元的丙烯酸块共聚物(a)，其中聚合物块A主要含有作为硬段的(甲基)丙烯酸酯单元，聚合物块B主要含有作为软段的丙烯酸酯单元，以及一种聚合单体(b)和一种聚合引发剂(c)。