3-苯胺基丙酰肼 | 4916-20-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-苯胺基丙酰肼
• 英文名称: 3-anilinopropionic acid hydrazide
• 英文别名: 3-(phenylamino)propanehydrazide；N-Phenyl-β-alaninhydrazid；3-Anilino-propionsaeure-hydrazid；3-(phenylamino)propanohydrazide；3-Anilinopropanohydrazide；3-anilinopropanehydrazide
• CAS: 4916-20-5
• 化学式: C₉H₁₃N₃O
• mdl: MFCD00559632
• 分子量: 179.222
• InChiKey: QOZMRVJLWMWVJR-UHFFFAOYSA-N

物化性质

• 熔点：
  95-96 °C
• 沸点：
  443.3±28.0 °C(Predicted)
• 密度：
  1.182±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  3-苯胺基丙酰肼 在 盐酸 、 sodium nitrate 作用下， 以 水 为溶剂， 反应 7.0h， 以82%的产率得到N-苯基乙二胺
  参考文献：
  名称：

  Yao, Ri-Sheng; Jiang, Lai-En; Wu, Sheng-Hua, Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3792 - 3794

  摘要：

  DOI：
• 作为产物：
  描述：

  3-苯基氨基丙酸 在 hydrazine hydrate 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以64.2%的产率得到3-苯胺基丙酰肼
  参考文献：
  名称：

  3-苯氨基丙酰肼的唑类衍生物的合成及抑菌效果评价

  摘要：

  含有苯氨基丙酰基部分的新型吡咯和吡唑衍生物由 3-苯氨基丙酰肼通过其与二酮的缩合合成。采用二取代氨基脲和氨基硫脲的分子内环化反应制备新的1,3,4-噻二唑、1,3,4-恶二唑和1,2,4-三唑化合物。评估了一些合成化合物的体外抗微生物活性。

  DOI：

  10.3987/com-08-11478

文献信息

• Novel N-Substituted Amino Acid Hydrazone-Isatin Derivatives: Synthesis, Antioxidant Activity, and Anticancer Activity in 2D and 3D Models In Vitro
  作者：Ingrida Tumosienė、Ilona Jonuškienė、Kristina Kantminienė、Vytautas Mickevičius、Vilma Petrikaitė

  DOI：10.3390/ijms22157799

  日期：——

  or diphenylamine fragments were synthesized, and their anticancer activities were tested by MTT assay against human melanoma A375 and colon adenocarcinoma HT-29 cell lines. In general, the synthesized compounds were more cytotoxic against HT-29 than A375. 3-((4-Methoxyphenyl)(3-oxo-3-(2-(2-oxoindolin-3-ylidene)hydrazinyl)propyl)amino)-N’-(2-oxoindolin-3-ylidene)propanehydrazide and (N’,N’’’)-1,1’-(methylenebis(4

  合成了一系列新的单腙和双腙，每个都带有 2-羟吲哚部分以及取代的苯氨基丙酰胺、吡咯烷-2-one、苯并咪唑、二苯甲烷或二苯胺片段，并通过 MTT 法测试了它们对人黑色素瘤 A375 和结肠的抗癌活性腺癌 HT-29 细胞系。一般来说，合成的化合物对 HT-29 的细胞毒性比 A375 更强。3-((4-甲氧基苯基)(3-oxo-3-(2-(2-oxoindolin-3-ylidene)hydrazinyl)丙基)amino) -N '-(2-oxoindolin-3-ylidene)丙酰肼和( N ', N ''')-1,1'-(亚甲基双(4,1-亚苯基))双(5-氧代-N'-(2-oxoindolin-3-ylidene)pyrrolidine-3-carbohydrazide) 被鉴定为在 2D 和 3D 细胞培养物中对抗 HT-29 的最活性化合物。在通过铁还原抗氧化能力测定 (FRAP)
• One liquid type epoxy resin composition
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0193068A1

  公开（公告）日：1986-09-03

  @ The present invention provides a one-liquid type epoxy resin composition which is useful especially as a coating material and adhesive for a wide range of applications. The resin composition comprises (1) an epoxy resin (A) containing at least an average of two epoxy groups per molecular unit; and (2) a curing agent (B) consisting essentially of a powdery amine compound (C) having a softening point of 50 to 150°C, the particles of said powdery amine compound being coated with at least one of the following layers: (i) a layer formed by adhesion to the surface of said particles of at least one compound selected from the group consisting of an isocyanate (D), a carboxylic acid (E), a carboxylic acid anhydride (F), an acid halogenated compound (G) and an epoxy compound (H); and (ii) a layer formed by covalent bonding of the powdery amine compound (C) with at least one compound selected from the group consisting of an isocyanate (D), a carboxylic acid (E), a carboxylic acid anhydride (F), an acid halogenated compound (G) and an epoxy compound (H); the softening temperature of said curing agent (B) being 5 to 50°C higher than the softening temperature of said powdery amine compound (C).

  本发明提供了一种单液型环氧树脂组合物，该组合物尤其可用作应用广泛的涂层材料和粘合剂。该树脂组合物包括 (1) 环氧树脂（A），平均每个分子单位至少含有两个环氧基团；以及 (2) 固化剂 (B) 主要由粉末状胺化合物 (C) 组成，其软化点为 50 至 150°C，所述粉末状胺化合物的颗粒上至少涂有以下一层： (i) 至少一种选自异氰酸酯 (D)、羧酸 (E)、羧酸酐 (F)、酸性卤化化合物 (G) 和环氧化合物 (H) 的化合物粘附在所述颗粒表面而形成的层；以及 (ii) 由粉状胺化合物（C）与至少一种选自异氰酸酯（D）、羧酸（E）、羧酸酐 （F）、酸卤化合物（G）和环氧化合物（H）的化合物共价键合而形成的层； 所述固化剂（B）的软化温度比所述粉状胺化合物（C）的软化温度高 5 至 50°C。
• Hardener for curable one-package epoxy resin system
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0304503A1

  公开（公告）日：1989-03-01

  A master batch of hardener for curable one-­package epoxy resin system which comprises (I) a hardener consisting of (I) a hardener consisting of (i) a powder of an amine compound (A) as a core having at least one tertiary amino group in the molecule while having no primary and secondary amino groups, the powder having both a group (X) capable of absorbing infrared rays of 1630 to 1680 cm⁻¹ in wave length and a group (Y) capable of absorbing infrared rays of 1680 to 1725 cm⁻¹ in wave length at least on the surface of the powder, and (ii) a reaction product of the amine compound (A) and an epoxy resin as a shell; and (II) an epoxy resin (B) in a ratio of 10 to 50,000 parts by weight to 100 parts by weight of the hardener (I). A hardener containing the master batch is also disclosed.

  一种用于固化单组分环氧树脂体系的母料固化剂，它包括 (I) 由以下成分组成的固化剂 (I) 由以下成分组成的固化剂 (i) 以胺化合物（A）为核心的粉末，其分子中至少有一个叔氨基，而没有伯氨基和仲氨基，该粉末的表面至少有一个能吸收波长为 1630 至 1680 厘米-¹的红外线的基团（X）和一个能吸收波长为 1680 至 1725 厘米-¹的红外线的基团（Y），和 (ii) 作为外壳的胺化合物（A）和环氧树脂的反应产物；以及 (II) 环氧树脂 (B)，其重量比为 10 至 50,000 份与固化剂 (I) 的重量比为 100 份。 还公开了一种含有母料的固化剂。
• Composition for vibration damper, process for manufacture thereof, and vibration damper
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0328411A2

  公开（公告）日：1989-08-16

  A composition for a vibration damper, which comprises: 100 parts by weight of a resin-forming component comprising (a) a compound containing an epoxy group, and (b) a curing component comprising (i) a polyhydric phenol as a first curing compound and (ii) a second curing compound selected from the group consisting of an acid hydrazide, a urea derivative and an imidazole; 50 to 500 parts by weight of a scaly filler; 200 parts by weight or less of powdery filler; and 100 parts by weight or less of a fibrous filler. A process for the manufacture of the composition, and a vibration damper, also are disclosed.

  一种用于减震器的组合物，它包括 按重量计，100 份树脂形成组分，包括(a) 含环氧基团的化合物，和(b) 固化组分，包括(i) 作为第一固化化合物的多氢苯酚和(ii) 从酸酰肼、脲衍生物和咪唑组成的组中选出的第二固化化合物； 50 至 500 重量份的鳞片状填料； 以重量计，200 份或更少粉状填料；以及 100 份（重量）或更少的纤维状填料。此外，还公开了该组合物的制造工艺和减震器。
• CAPSULE TYPE HARDENER AND COMPOSITION
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1557438A1

  公开（公告）日：2005-07-27

  A capsule type curing agent which comprises a core containing an amine type curing agent (A) and a capsule and a membrane covering said core, wherein said capsule membrane has a bonding group (x) absorbing infrared ray of a wave-number of 1630 to 1680 cm-1 and/or a bonding group (y) absorbing infrared ray of a wave-number of 1680 to 1725 cm-1, and contains cured material of an epoxy resin by the amine type curing agent (A) as a curing agent, and weight ratio of the core and the capsule membrane is 100:1 to 100:100.

  一种胶囊型固化剂，包括含有胺类固化剂（A）的芯和覆盖所述芯的胶囊和膜，其中所述胶囊膜具有吸收波数为 1630 至 1680 cm-1 的红外线的键合基团（x）和/或吸收波数为 1680 至 1725 cm-1 的红外线的键合基团（y）、并含有以胺类固化剂（A）为固化剂的环氧树脂固化物，芯材与胶囊膜的重量比为 100：1 至 100:100。