ethylcyclohexylcarbonyl chloride | 1029128-58-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: ethylcyclohexylcarbonyl chloride
• 英文别名: 1-Ethyl-cyclohexan-carbonsaeure-chlorid；1-Ethylcyclohexane-1-carbonyl chloride
• CAS: 1029128-58-2
• 化学式: C₉H₁₅ClO
• 分子量: 174.671
• InChiKey: AALDCKVKKXNGJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ethylcyclohexylcarbonyl chloride 在 吡啶 、 水 、 三苯基膦 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-(2-mercaptophenyl)-1-ethylcyclohexanecarboxamide
  参考文献：
  名称：

  Bis(2-(Acylamino)phenyl) Disulfides, 2-(Acylamino)benzenethiols, and S-(2-(Acylamino)phenyl) Alkanethioates as Novel Inhibitors of Cholesteryl Ester Transfer Protein

  摘要：

  A series of bis(2-(acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, S-(2-(acylamino)phenyl) alkanethioates, and related compounds were synthesized, and their inhibitory effect on cholesteryl ester transfer protein activity in human plasma was evaluated. This study elucidated the structural requirements for inhibitory activity and determined that the optimum compound was S-(2-((1-(2-ethylbutyl)cyclohexane)carbonylamino)phenyl) 2-methylpropanethioate (27) (JTT-705). This compound achieved 50% inhibition of CETP activity in human plasma at a concentration of 9 mu M and 95% inhibition of CETP activity in male Japanese white rabbits at an oral dose of 30 mg/kg. It increased the plasma HDL cholesterol level by 27% and 54%, respectively, when given at oral doses of 30 or 100 mg/kg once a day for 3 days to male Japanese white rabbits.

  DOI：

  10.1021/jm000224s
• 作为产物：
  描述：

  环己甲酸甲酯 在 甲醇 、 草酰氯 、 sodium hydroxide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 ethylcyclohexylcarbonyl chloride
  参考文献：
  名称：

  铜催化未活化C（sp3）的位点选择性分子内酰胺化反应？H债券

  摘要：

  脂肪族酰胺的分子内酰胺化脱氢，由双齿配体定向，使用铜-催化的SP被开发3 Ç  H键官能化方法。该反应有利于主要的C  β甲基团与未活化的亚甲基] C H键 H键。此外，用于激活SP的偏好3 Ç  β甲基基团的H键，经由五元环中间，在所述芳族SP 2个ç  H键在环金属化步骤中也观察到。此外，SP 3个Ç 未活化二次属的H键3 Ç 通过使环碳原子优先于线性碳原子，可以使H键官能化。

  DOI：

  10.1002/anie.201311263

文献信息

• Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists
  作者：Guo-Hua Chu、Christopher T. Saeui、Karin Worm、Damian G. Weaver、Allan J. Goodman、Robert L. Broadrup、Joel A. Cassel、Robert N. DeHaven、Christopher J. LaBuda、Michael Koblish、Bernice Brogdon、Steve Smith、Bertrand Le Bourdonnec、Roland E. Dolle

  DOI：10.1016/j.bmcl.2009.08.063

  日期：2009.10

  Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a

  用吡啶环取代我们以前的（吗啉代甲基）苯胺羧酰胺大麻素受体配体中的苯环，导致发现了新的化学系列CB 2配体。化合物3（即2,2-二甲基-N-（5-甲基-4-（吗啉代甲基）吡啶基-2-基）丁酰胺）被确定为有效和选择性的CB 2激动剂，口服后在体内给药。神经性疼痛的大鼠模型。
• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• PROCESS FOR THE PREPARATION OF ACYLPHENYLALANINES
  申请人：Ajinomoto Co., Inc.

  公开号：EP1334962A1

  公开（公告）日：2003-08-13

  There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.

  本发明提供了一种易于生产高纯度酰基苯丙氨酸的方法，这种酰基苯丙氨酸可用作医药产品等的原料，该方法包括以下步骤：在有机溶剂和水的混合溶剂中，使氯化酸与苯丙氨酸反应，同时使用氢氧化钾将溶剂保持在碱性条件下。
• Methods for producing acylphenylalanine
  申请人：AJINOMOTO CO. INC

  公开号：US20040024219A1

  公开（公告）日：2004-02-05

  There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.

  本发明提供了一种易于生产高纯度酰基苯丙氨酸的方法，这种酰基苯丙氨酸可用作医药产品等的原料，该方法包括以下步骤：在有机溶剂和水的混合溶剂中，使氯化酸与苯丙氨酸反应，同时使用氢氧化钾将溶剂保持在碱性条件下。
• Rouzaud,J. et al., Bulletin de la Societe Chimique de France, 1965, p. 2030 - 2037
  作者：Rouzaud,J. et al.

  DOI：——

  日期：——