Acid hydrolysis of unsymmetrical N1, N2-disubstituted acetamidine and formamidine was examined kinetically in aqueous dioxane solution. The reaction afforded the more basic amine and the N-acyl derivative of the less basic amine. Increasing the dioxane content in the solvent increased the reaction rate. The reaction can be rationalized in terms of specific acid-general base catalysis.
在
水合
二氧六环溶液中,动力学研究了不对称N1, N2-二取代乙酰胺和甲酰胺的酸性
水解反应。该反应生成了更碱性的胺和较不碱性胺的N-酰衍
生物。增加溶剂中
二氧六环的含量提高了反应速率。该反应可以通过特定酸-一般碱催化的理论进行解释。