1,2-octadecanediamine | 13880-38-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-octadecanediamine
• 英文别名: 1.2-Diamino-octadecan；1-hexadecyl-ethanediyldiamine；1-Hexadecyl-aethandiyldiamin；1,2-Diaminooctade-cane；octadecane-1,2-diamine
• CAS: 13880-38-1
• 化学式: C₁₈H₄₀N₂
• 分子量: 284.529
• InChiKey: OZHHORSAJPKQSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-octadecanediamine 、 2,2'-azo(2-amidinopropane)[2-(2-imidazolin-2-yl)propane] dihydrochloride 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 48.5h， 生成 2,2'azo[2-(2-imidiazolin-2-yl)propane]{2-[2-(4-n-hexadecyl)imidazolin-2-yl]propane}
  参考文献：
  名称：

  Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins

  摘要：

  Lipid peroxidation studies often employ the use of azo initiators to produce a slow, steady source of free radicals, but the lack of initiators capable of efficiently generating radicals in lipid aggregates such as micelles and membranes has created persistent problems in these investigations. We report here the synthesis and study of unsymmetrically substituted (hydrophilic/hydrophobic) azo initiators C-8, C-12, and C-16 that increase the efficiency of radical generation in lipophilic regions of aqueous emulsions such as micelles and liposomes. Radical generation from these initiators was monitored in micelles? liposomes, and lipoproteins by the use of two radical scavengers, one that scavengers lipophilic peroxyl radicals and one that scavenges hydrophilic peroxyls. The lipophilic radical scavenger used was the well-known antioxidant alpha-tocopherol and thr hydrophilic radical scavenger used was uric acid. Two peroxyl radicals are trapped by each of these scavengers, tocopherol presumably being biased toward reacting with lipid soluble radicals, uric acid presumably reacting preferentially with water-soluble radicals. In Triton X-100 micelles the unsymmetrical initiators C-8 and C-16 display an increase in both alpha-TOH (alpha-tocopherol) trapping and in overall radical generation efficiency compared to the symmetrical initiators C-0 (hydrophilic) and MeOAMVN (lipophilic). The unsymmetrical azo initiators performance in liposomes was excellent (increased cage escape with lipid compartment access). In low-density lipoprotein oxidations, the initiators C-8, C-12, and C-16 also provided advantages over C-0 and MeOAMVN. The hydrophilic/hydrophobic character of the two radicals generated from the unsymmetrical initiators is an important factor for separating the geminate radical pair, These initiators, when compared to the widely used symmetrical azo initiators, provide an advantage of free radical production, lipophilic access, and constant radical generation in the investigation of lipid peroxidation in various media.

  DOI：

  10.1021/ja9934605
• 作为产物：
  描述：

  溴代十六烷 在 lithium aluminium tetrahydride 、 氯化亚砜 、 乙醇 、 氨 、 sodium 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 192.0h， 生成 1,2-octadecanediamine
  参考文献：
  名称：

  Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins

  摘要：

  Lipid peroxidation studies often employ the use of azo initiators to produce a slow, steady source of free radicals, but the lack of initiators capable of efficiently generating radicals in lipid aggregates such as micelles and membranes has created persistent problems in these investigations. We report here the synthesis and study of unsymmetrically substituted (hydrophilic/hydrophobic) azo initiators C-8, C-12, and C-16 that increase the efficiency of radical generation in lipophilic regions of aqueous emulsions such as micelles and liposomes. Radical generation from these initiators was monitored in micelles? liposomes, and lipoproteins by the use of two radical scavengers, one that scavengers lipophilic peroxyl radicals and one that scavenges hydrophilic peroxyls. The lipophilic radical scavenger used was the well-known antioxidant alpha-tocopherol and thr hydrophilic radical scavenger used was uric acid. Two peroxyl radicals are trapped by each of these scavengers, tocopherol presumably being biased toward reacting with lipid soluble radicals, uric acid presumably reacting preferentially with water-soluble radicals. In Triton X-100 micelles the unsymmetrical initiators C-8 and C-16 display an increase in both alpha-TOH (alpha-tocopherol) trapping and in overall radical generation efficiency compared to the symmetrical initiators C-0 (hydrophilic) and MeOAMVN (lipophilic). The unsymmetrical azo initiators performance in liposomes was excellent (increased cage escape with lipid compartment access). In low-density lipoprotein oxidations, the initiators C-8, C-12, and C-16 also provided advantages over C-0 and MeOAMVN. The hydrophilic/hydrophobic character of the two radicals generated from the unsymmetrical initiators is an important factor for separating the geminate radical pair, These initiators, when compared to the widely used symmetrical azo initiators, provide an advantage of free radical production, lipophilic access, and constant radical generation in the investigation of lipid peroxidation in various media.

  DOI：

  10.1021/ja9934605

文献信息

• Supramolecular assemblies based on amphiphilic Mn²⁺-complexes as high relaxivity MRI probes
  作者：Gabriele Rolla、Valeria De Biasio、Giovanni B. Giovenzana、Mauro Botta、Lorenzo Tei

  DOI：10.1039/c8dt01250d

  日期：——

  In the research field of MRI contrast agents (CAs), amphiphilic paramagnetic complexes are typically sought for the increased plasmatic half-life and high relaxivity values, but limited examples of amphiphilic Mn2+-based CAs have been reported to date. In this work the Mn2+-complexes of six original amphiphilic ligands (three EDTA-like ligands and three 1,4-DO2A derivatives) embodying one or two aliphatic

  在MRI造影剂（CA）的研究领域中，通常寻求两亲顺磁性络合物以增加血浆半衰期和高弛豫值，但是迄今为止已经报道了基于两亲Mn 2+的CA的有限实例。在这项工作中，包含一个或两个脂族链的六个原始两亲性配体（三个EDTA状配体和三个1,4-DO2A衍生物）的Mn 2+复合物被评估为潜在的MRI造影剂并进行了比较。由于超分子聚集体的分子翻滚速率增加，强烈的自缔合成胶束导致弛豫性（r 1）增强（相对于MnEDTA约80％）。对于双取代系统，由于螯合剂围绕脂肪族侧链的局限旋转，r 1的增益要高得多（r 1在12.6-18.4 mM -1 s -1的范围内，是单链胶束的2-3倍EDTA系统）。此外，这些两亲性螯合物以10 4 –10 5 M -1的缔合常数K A与人血清白蛋白（HSA）紧密结合。所得的超分子加合物达到了显着的弛豫值，对于MnEDTA状螯合物而言，在50-60 mM -1 s -1范围内，在27-30
• ORGANIC MOLYBDENUM ADDITIVE, ITS PREPARATION METHOD, A LUBRICATING COMPOSITION CONTAINING SAID ADDITIVE, AND USE OF THE SAME
  申请人：Xu Wei

  公开号：US20090156443A1

  公开（公告）日：2009-06-18

  The present invention relates to an organic molybdenum additive and its preparation method, and a lubricating composition comprising said additive, and use of said additive and its lubricating composition in the aspect of improving antiwear and antifriction property of oil products. The organic molybdenum additive according to the present invention is characterized in that it is prepared by reacting several kinds of feedstock as follows: a polylol ester of p-hydroxybenzene alkyl acid, an inorganic molybdenum compound and an aliphatic amine and/or an aromatic amine and/or an amide. The organic molybdenum additive of the present invention has excellent antiwear and/or antifriction property.

  本发明涉及一种有机钼添加剂及其制备方法，以及包括该添加剂的润滑组合物，以及在改善油产品的抗磨和抗摩擦性方面使用该添加剂及其润滑组合物的用途。本发明的有机钼添加剂的特点在于，它是通过以下几种原料反应制备而成的：对羟基苯基醇酯、无机钼化合物和脂肪胺和/或芳香胺和/或酰胺。本发明的有机钼添加剂具有优异的抗磨和/或抗摩擦性能。
• Expandable olefin polymer composition, expanded products made therefrom and method of making the expanded products
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0001791A2

  公开（公告）日：1979-05-16

  A thermoplastic synthetic resin such as polyethylene or ethylene-vinyl acetate copolymer resin containing 0.1 to 10 wt. % of a specific additive selected from specific classes of compounds, namely saturated higher fatty acid amidas, saturated higher aliphatic amines and complete esters of saturated higher fatty acids is found to be very suitable for production of expanded articles and can be easily formed into expanded articles with little shrinkage after expansion, free from creases on the surface or cracks on the cell walls, and having excellent characteristics such as good closed cellular characteristic, high compressive strength, low density. etc.

  一种热塑性合成树脂，如聚乙烯或乙烯-醋酸乙烯共聚物树脂，含有 0.1 至 10 wt.%的特定添加剂，这些添加剂选自特定类别的化合物，即饱和高级脂肪酸酰胺、饱和高级脂肪族胺和饱和高级脂肪酸完全酯，这种添加剂非常适合用于生产发泡制品，而且可以很容易地制成发泡制品，发泡后收缩率小，表面无皱褶，细胞壁无裂纹，具有良好的封闭细胞特性、高抗压强度、低密度等优异特性。
• Enzymatic peracid bleaching system
  申请人：The Clorox Company

  公开号：EP0268456A2

  公开（公告）日：1988-05-25

  An enzymatic perhydrolysis system, useful for bleaching, has a novel enzyme, a substrate, and a source of hydrogen peroxide, and provides in situ formation of peracid in aqueous solution. The substrate is selected for enzyme catalyzed reaction, and preferably is an acylglycerol with two or three fatty acid chains. The enzyme is hydrolytically and perhydrolytically active even in the presence of anionic surfactants, has lipase acitivity, and is isolatable from Pseudomonas putida ATCC 53552.

  一种可用于漂白的酶过水解系统具有一种新型酶、一种底物和一种过氧化氢源，可在水溶液中就地形成过酸。底物选择用于酶催化反应，最好是具有两个或三个脂肪酸链的酰基甘油。该酶即使在阴离子表面活性剂存在的情况下也具有水解和过水解活性，具有脂肪酶活性，可从假单胞菌 ATCC 53552 中分离出来。
• Process for producing azo group-containing polymer having azo group in main chain
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0319197A2

  公开（公告）日：1989-06-07

  A process for producing an azo group-containing polymer which comprises polycondensing: (A) an azo-containing compound having an azo group in the main molecular chain and alcoholic hydroxyl, phenolic hydroxyl, imino or amino groups at both ends thereof, or a modified azo-containing compound which has been prepared by reacting a compound having an azo group in the main molecular chain and alcoholic hydroxyl groups at both ends thereof with a dicarboxylic acid chloride, with (B) a carbonate precursor, or when (A) is the azo-containing compound, a dicarboxylic acid, with the proviso that when the azo-containing compound is the compound having an azo group in the main molecular chain and alcoholic hydroxyl groups at both ends thereof (B) is not a carbonate precursor.

  一种生产含偶氮基聚合物的工艺，包括缩聚： (A) 主分子链中含有偶氮基团且其两端含有醇羟基、酚羟基、亚氨基或氨基的含偶氮 化合物，或通过使主分子链中含有偶氮基团且其两端含有醇羟基的化合物与氯化二 羧酸反应制备的改性含偶氮化合物，与 (B) 碳酸前体，或当(A)为含偶氮的化合物时，二羧酸、 但当含偶氮的化合物是主分子链中含有偶氮基团而其两端含有醇羟基的化合物时，(B) 不是碳酸盐前体。