2-(3-羟基苯基)苯酚 | 31835-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3-羟基苯基)苯酚
• 英文名称: 1,1'-biphenyl-2,3'-diol
• 英文别名: biphenyl-2,3'-diol；biphenol；[1,1'-Biphenyl]-2,3'-diol；2-(3-hydroxyphenyl)phenol
• CAS: 31835-45-7
• 化学式: C₁₂H₁₀O₂
• 分子量: 186.21
• InChiKey: XKZQKPRCPNGNFR-UHFFFAOYSA-N

物化性质

• 沸点：
  370.4±25.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-chloro-dibenzo[d,f][1,3,2]-dioxaphosphepin 、 2-(3-羟基苯基)苯酚 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以30%的产率得到6,6′-([1,1′-biphenyl]-2,3′-diylbis(oxy))didibenzo[d,f][1,3,2]dioxaphosphepin
  参考文献：
  名称：

  6,6'-([1,1'-BIPHENYL]-2,3'-DIYLBIS(OXY))DIDIBENZO[D,F][1,3,2]DIOXAPHOSPHEPINES

  摘要：

  6,6'-([1,1'-联苯]-2,3'-二氧基)二苯并[d,f][1,3,2]二氧磷杂环庚烷及其在氢甲酰化中的应用。

  公开号：

  US20220056059A1
• 作为产物：
  描述：

  3-碘苯酚 、 2-羟基苯硼酸 在 palladium 10% on activated carbon 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 2.5h， 以93%的产率得到2-(3-羟基苯基)苯酚
  参考文献：
  名称：

  Suzuki–Miyaura Coupling of Halophenols and Phenol Boronic Acids: Systematic Investigation of Positional Isomer Effects and Conclusions for the Synthesis of Phytoalexins from Pyrinae

  摘要：

  The Suzuki-Miyaura couplings of o-, m-, and p-halophenols with o-, m-, and p-phenol boronic acids were investigated for all combinations under standardized conditions, using Pd/C as a heterogeneous catalyst and water as a solvent. In the case of iodophenols, conventional heating was used, while for bromophenols significantly better results could be obtained using microwave irradiation. This systematic study revealed that 2,4'-biphenol is particularly difficult to access, irrespective of the starting materials used, but that these difficulties can be overcome by using different additives. The conclusions drawn from this investigation allowed us to identify conditions for the protecting group-free or minimized total synthesis of biaryl-type phytoalexins. These compounds possess antibacterial activity and are produced by fruit trees as a response to microbial infection.

  DOI：

  10.1021/jo500675a

文献信息

• Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
  作者：Brittany A. Moser、Yoseline Escalante-Buendia、Rachel C. Steinhardt、Matthew G. Rosenberger、Britteny J. Cassaidy、Nihesh Naorem、Alfred C. Chon、Minh H. Nguyen、Ngoctran T. Tran、Aaron P. Esser-Kahn

  DOI：10.3389/fimmu.2020.511513

  日期：——

  Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease

  疫苗中添加佐剂可增强免疫反应并增强对疾病的保护。在过去的十年中，数百种合成免疫佐剂被创造出来，但许多都会诱导促炎细胞因子（包括 TNF-α 和 IL-6）达到不良水平。在这里，我们提出了小分子 NF-κB 抑制剂，可与免疫佐剂联合使用，以减少与耐受性差相关的标记物并改善疫苗接种的保护反应。此外，我们合成了和厚朴酚衍生物库，确定了几种有希望用于疫苗制剂的候选物。
• BISPHOSPHITES HAVING AN OUTER NAPHTHYL-PHENYL UNIT AND A CENTRAL 2,3'-BIPHENOL UNIT
  申请人：DYBALLA Katrin Marie

  公开号：US20160159836A1

  公开（公告）日：2016-06-09

  Bisphosphites having an outer naphthyl-phenyl unit and a central 2,3′-biphenol unit and their preparation are described.

  描述了具有外部萘基苯基单元和中央2,3'-联苯酚单元的双膦酸盐及其制备。
• BISPHOSPHITES HAVING A CENTRAL 2,3'-BIPHENOL UNIT
  申请人：DYBALLA Katrin Marie

  公开号：US20160185685A1

  公开（公告）日：2016-06-30

  Bisphosphites having a central 2,3′-biphenol unit are useful for catalyzing hydroformylation.

  含有中心2,3'-联苯酚单元的双膦酸酯对催化氢甲酰化反应很有用。
• [EN] ALKYLATION OF PHENOLIC COMPOUNDS<br/>[FR] ALKYLATION DE COMPOSÉS PHÉNOLIQUES
  申请人：UNIV SYDNEY

  公开号：WO2015051402A1

  公开（公告）日：2015-04-16

  The invention relates to a process for O-alkyiation of a phenolic compound comprising at least two hydroxyl groups bonded to an aromatic hydrocarbon, the process comprising reacting the phenolic compound with an alkylating agent in the presence of a base, at a suitable reaction temperature and for a suitable time period, thereby alkylating the at least two hydroxy] groups. The invention also relates to O-alkylaled phenolic compounds produced by this process.

  这项发明涉及一种用于对含有至少两个羟基与芳香烃键合的酚类化合物进行O-烷基化的过程，该过程包括在碱的存在下，将酚类化合物与烷基化剂在适当的反应温度和适当的时间内反应，从而使至少两个羟基发生烷基化。该发明还涉及由该过程产生的O-烷基化酚类化合物。
• METHOD FOR PRODUCING HYDROGENATED BIPHENOL
  申请人：Daicel Corporation

  公开号：EP2837615A1

  公开（公告）日：2015-02-18

  Provided is a method for efficiently producing high-purity hydrogenated biphenol based on a simple method that can be industrially utilized using easily-available biphenol as a starting material. The method for producing hydrogenated biphenol according to the present invention is a method for producing hydrogenated biphenol by hydrogenating biphenol represented by the following formula (1): to obtain hydrogenated biphenol represented by the following formula (2): the method comprising: a reaction step of hydrogenating the biphenol represented by formula (1); and a purification step of washing or crystallizing a reaction product obtained from the reaction step using an aromatic hydrocarbon.

  提供了一种高效生产高纯度氢化双苯酚的方法，该方法基于一种简单的方法，可以利用易得的双苯酚作为起始材料进行工业化利用。根据本发明的生产氢化双苯酚的方法是通过对以下式（1）所表示的双苯酚进行氢化反应，以获得以下式（2）所表示的氢化双苯酚的方法，该方法包括：对式（1）所表示的双苯酚进行氢化反应的反应步骤；以及使用芳香烃洗涤或结晶反应步骤得到的反应产物的纯化步骤。