毒理性
◉ 母乳喂养期间使用概要：SAM-e（S-腺苷甲硫氨酸）是一种天然存在的甲基供体，参与人类和动物体内的酶促转甲基反应。SAM-e 没有特定的与哺乳相关的用途，但已被用于治疗产后抑郁症、胆汁淤积性黄疸、骨关节炎以及许多其他疾病。SAM-e 口服生物利用度较差。成年人大体上可以很好地耐受 SAM-e。最常见的不良反应是胃肠道反应，如恶心。也有报道出现皮疹。目前没有关于哺乳期间使用 SAM-e 的临床信息。然而，哺乳母亲使用 SAM-e 不太可能对哺乳的婴儿造成任何不良影响，尤其是如果婴儿已经超过2个月大。
膳食补充剂不需要美国食品药品监督管理局的广泛市场前批准。制造商负责确保安全性，但在市场销售前不需要证明膳食补充剂的安全性和有效性。膳食补充剂可能含有多种成分，标签上标注的成分或其含量与实际成分或含量常常存在差异。制造商可以与独立组织签订合同，以验证产品或其成分的质量，但这并不证明产品的安全或有效性。由于上述问题，一个产品的临床测试结果可能不适用于其他产品。关于膳食补充剂的更详细信息可以在 LactMed 网站的其他地方找到。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对哺乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:SAM-e (S-adenosylmethionine) is a naturally occurring methyl radical donor involved in enzymatic transmethylation reactions in humans and animals. SAM-e has no specific lactation-related uses, but it has been used therapeutically for treating postpartum depression, cholestatic jaundice, osteoarthritis and numerous other conditions. SAM-e has poor oral bioavailability. SAM-e is generally well tolerated in adults. The most frequent adverse effects reported are gastrointestinal, such as nausea. Skin rashes have also been reported. No information is available on the clinical use of SAM-e during breastfeeding. However, use of SAM-e by a nursing mother would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.
Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
